TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 468.633 | Formula: C21H32N4O4S2
H donors: 1 H acceptors: 5 LogP: 3.48 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](N1CCN(CC1=O)S(=O)(=O)C1CCCC1)CC1CCCCC1)Nc1nccs1
InChi: 1S/C21H32N4O4S2/c26-19-15-24(31(28,29)17-8-4-5-9-17)11-12-25(19)18(14-16-6-2-1-3-7-16)20(27)23-21-22-10-13-30-21/h10,13,16-18H,1-9,11-12,14-15H2,(H,22,23,27)/t18-/m0/s1
InChiKey: XDIWPYYDLRTNOH-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucokinase (hexokinase 4)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania donovani	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium yoelii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium hominis	hexokinase i	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium vivax	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	Hexokinase family protein	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 2	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Babesia bovis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Neospora caninum	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma congolense	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium berghei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase type II	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium parvum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Toxoplasma gondii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 1	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma mansoni	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium falciparum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium knowlesi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Treponema pallidum	hexokinase (hxk)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma japonicum	ko:K00844 hexokinase [EC2.7.1.1], putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania braziliensis	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hexokinase family protein	glucokinase (hexokinase 4)	465 aa	470 aa	30.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1356	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0781	0.5545	0.5545
Brugia malayi	Tyrosine-protein kinase abl-1	0.1356	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/RYK protein kinase	0.0781	0.5545	0.5545
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1356	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1356	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0575	0.3947	0.38
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0575	0.3947	0.38
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK/CSK protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Trypanosoma brucei	Pseudokinase, putative	0.0781	0.5545	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1356	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0781	0.5545	0.5545
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1356	1	1
Echinococcus multilocularis	tensin	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Brugia malayi	Tyrosine-protein kinase PR2	0.0781	0.5545	0.5437
Brugia malayi	hypothetical protein	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase Blk	0.1356	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	receptor protein kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	cysteine surface protein, putative	0.0781	0.5545	0.5437
Plasmodium falciparum	tyrosine kinase-like protein	0.0781	0.5545	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0575	0.3947	0.3947
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Leishmania major	protein kinase, putative	0.0781	0.5545	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1356	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0781	0.5545	0.5437
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0575	0.3947	0.38
Schistosoma mansoni	serine/threonine protein kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0575	0.3947	0.38
Plasmodium falciparum	protein kinase, putative	0.0781	0.5545	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1356	1	1
Echinococcus multilocularis	activin receptor type	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1356	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1356	1	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0781	0.5545	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0781	0.5545	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0781	0.5545	0.5437
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0781	0.5545	0.5437
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0781	0.5545	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0575	0.3947	0.38
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus granulosus	activated cdc42 kinase 1	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	SRC-1	0.1356	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0575	0.3947	0.38
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	AGC family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0575	0.3947	0.38
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0575	0.3947	0.3947
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0781	0.5545	0.5437
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0781	0.5545	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0781	0.5545	1
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Echinococcus multilocularis	epidermal growth factor receptor	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0781	0.5545	0.5437
Onchocerca volvulus		0.1356	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0781	0.5545	0.5545
Trypanosoma cruzi	protein kinase, putative	0.0781	0.5545	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.1356	1	1
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0575	0.3947	0.38
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0781	0.5545	0.5437
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine kinase	0.0781	0.5545	0.5437
Plasmodium vivax	protein kinase, putative	0.0781	0.5545	1
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase shark	0.1356	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0575	0.3947	0.38
Brugia malayi	SH2 domain containing protein	0.1356	1	1
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	NCK adaptor protein	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	growth factor receptor-bound protein	0.0575	0.3947	0.38
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0575	0.3947	0.38
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0575	0.3947	0.38
Schistosoma mansoni	hypothetical protein	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0781	0.5545	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	serine/threonine RGC	0.0781	0.5545	0.5437
Echinococcus multilocularis	tensin	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0781	0.5545	0.5437
Echinococcus granulosus	kinase suppressor of Ras 1	0.0781	0.5545	0.5437
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0781	0.5545	0.5437
Echinococcus granulosus	SH2 domain containing protein 7	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Schistosoma mansoni	serine/threonine protein kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0575	0.3947	0.38
Onchocerca volvulus		0.1356	1	1
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0781	0.5545	0.5437
Echinococcus multilocularis	SH2 domain containing protein 7	0.0575	0.3947	0.38
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	insulin receptor	0.0781	0.5545	0.5437
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Echinococcus multilocularis	protein kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hexokinase type II	0.0096	0.0237	0.0237
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1356	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1356	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0575	0.3947	0.38
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1356	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0575	0.3947	0.38
Onchocerca volvulus		0.1356	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0781	0.5545	0.5545
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	expressed conserved protein	0.0575	0.3947	0.38
Entamoeba histolytica	ankyrin repeat protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0781	0.5545	0.5545
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0781	0.5545	0.5437
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0781	0.5545	1
Entamoeba histolytica	tyrosin kinase, putative	0.0781	0.5545	0.5437
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1356	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Onchocerca volvulus		0.1356	1	1
Schistosoma mansoni	GTPase activating protein	0.0575	0.3947	0.38
Brugia malayi	SH2 domain containing protein	0.1356	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0781	0.5545	0.5437
Trypanosoma cruzi	protein kinase, putative	0.0781	0.5545	1
Entamoeba histolytica	protein kinase, putative	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0575	0.3947	0.38
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1356	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1356	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Echinococcus granulosus	SH2 motif	0.0575	0.3947	0.38
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Echinococcus granulosus	integrin linked protein kinase	0.0781	0.5545	0.5437
Echinococcus granulosus	ephrin type A receptor 4 A	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Onchocerca volvulus		0.0575	0.3947	0.38
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1356	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TK family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Onchocerca volvulus		0.0575	0.3947	0.38
Schistosoma mansoni	adapter molecule crk	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Onchocerca volvulus		0.1356	1	1
Onchocerca volvulus		0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Schistosoma mansoni	tensin	0.0575	0.3947	0.38
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Plasmodium falciparum	tyrosine kinase-like protein	0.0781	0.5545	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1356	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0575	0.3947	0.38
Brugia malayi	Raf kinase	0.0781	0.5545	0.5437
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Echinococcus multilocularis		0.0575	0.3947	0.38
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Schistosoma mansoni	growth factor receptor-bound protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0781	0.5545	0.5545
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Schistosoma mansoni	hypothetical protein	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1356	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0781	0.5545	0.5437
Brugia malayi	protein-tyrosine kinase	0.1356	1	1
Echinococcus granulosus	N chimaerin	0.0575	0.3947	0.38
Echinococcus granulosus	protein kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Brugia malayi	Furin-like cysteine rich region family protein	0.0781	0.5545	0.5437
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0781	0.5545	0.5437
Echinococcus multilocularis	insulin receptor	0.0781	0.5545	0.5437
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0781	0.5545	0.5437
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0575	0.3947	0.38
Echinococcus multilocularis	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1356	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1356	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Toxoplasma gondii	protein kinase	0.0781	0.5545	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1356	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0781	0.5545	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0781	0.5545	0.5545
Echinococcus granulosus	tyrosine protein kinase Srms	0.1356	1	1
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	Protein kinase domain containing protein	0.1356	1	1
Onchocerca volvulus		0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus granulosus	protein tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0781	0.5545	0.5545
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Echinococcus multilocularis	transfer RNA-Thr	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	hypothetical protein	0.0575	0.3947	0.38
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0575	0.3947	0.38
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0781	0.5545	0.5437
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0575	0.3947	0.3947
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.1356	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/ABL protein kinase	0.1356	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hexokinase	0.0096	0.0237	0.0237
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase pr2	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Plasmodium falciparum	protein kinase, putative	0.0781	0.5545	1
Leishmania major	protein kinase, putative	0.0781	0.5545	1
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	hypothetical protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0575	0.3947	0.38
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Echinococcus granulosus	raf serine:threonine protein kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Brugia malayi	Guanylyl cyclase protein 23	0.0781	0.5545	0.5437
Echinococcus granulosus	SH2 motif	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0575	0.3947	0.38
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0781	0.5545	0.5437
Schistosoma mansoni	tensin-related	0.0575	0.3947	0.38
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0781	0.5545	0.5437
Echinococcus granulosus	NCK adaptor protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK/FAK protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	natriuretic peptide receptor 1	0.0781	0.5545	0.5437
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Plasmodium falciparum	protein kinase, putative	0.0781	0.5545	1
Brugia malayi	Sex muscle abnormal protein 5	0.0575	0.3947	0.38
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	SH2 motif	0.0575	0.3947	0.38
Schistosoma mansoni	SH2A	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK/ROR protein kinase	0.0781	0.5545	0.5545
Schistosoma mansoni	vav2	0.0575	0.3947	0.38
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0575	0.3947	0.38
Entamoeba histolytica	receptor protein kinase, putative	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0575	0.3947	0.38
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0575	0.3947	0.38
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Echinococcus granulosus	hypothetical protein	0.0575	0.3947	0.38
Treponema pallidum	hexokinase (hxk)	0.0096	0.0237	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0575	0.3947	0.38
Echinococcus multilocularis	activated cdc42 kinase 1	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	SH2 domain-containing protein	0.0575	0.3947	0.3947
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine kinase	0.1356	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0575	0.3947	0.3947
Echinococcus granulosus	tensin	0.0575	0.3947	0.38
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase HCK	0.0781	0.5545	0.5437
Brugia malayi	Variant SH3 domain containing protein	0.0575	0.3947	0.38
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0575	0.3947	0.38
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	hypothetical protein	0.0781	0.5545	0.5437
Echinococcus granulosus	signal transduction protein lnk realted	0.0575	0.3947	0.38
Echinococcus granulosus	activin receptor type	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Trichomonas vaginalis	STE family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0575	0.3947	0.3947
Onchocerca volvulus		0.0781	0.5545	0.5437
Echinococcus multilocularis	protein kinase	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	serine/threonine protein kinase	0.0781	0.5545	0.5545
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK protein kinase	0.0781	0.5545	0.5545
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	serine/threonine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0781	0.5545	0.5437
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0575	0.3947	0.38
Giardia lamblia	Kinase	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0781	0.5545	0.5437
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0781	0.5545	0.5437
Echinococcus multilocularis	c src tyrosine kinase	0.1356	1	1
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	TK protein kinase	0.1356	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0575	0.3947	0.3947
Schistosoma mansoni	tensin-related	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1356	1	1
Echinococcus multilocularis	SH2 motif	0.0575	0.3947	0.38
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Brugia malayi	Variant SH3 domain containing protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0575	0.3947	0.3947
Brugia malayi	Receptor family ligand binding region containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	receptor type guanylyl cyclase	0.0781	0.5545	0.5437
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0781	0.5545	1
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	integrin-linked kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	STAT protein	0.0575	0.3947	0.3947
Loa Loa (eye worm)	TK/ACK protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0781	0.5545	0.5437
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0781	0.5545	1
Echinococcus multilocularis	tyrosine kinase	0.1356	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK/EPH protein kinase	0.0781	0.5545	0.5545
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0781	0.5545	0.5437
Brugia malayi	RhoGAP domain containing protein	0.0575	0.3947	0.38
Echinococcus multilocularis	heat shock protein 70	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0781	0.5545	0.5437
Entamoeba histolytica	tyrosin kinase, putative	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hexokinase	0.0096	0.0237	0.0237
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Schistosoma mansoni	tensin	0.0575	0.3947	0.38
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1356	1	1
Schistosoma mansoni	shc transforming protein	0.0575	0.3947	0.38
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0575	0.3947	0.38
Schistosoma mansoni	ephrin receptor	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0575	0.3947	0.38
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.1356	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.0781	0.5545	0.5545
Schistosoma mansoni	ephrin receptor	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0781	0.5545	0.5545
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Onchocerca volvulus		0.0575	0.3947	0.38
Brugia malayi	Tensin	0.0575	0.3947	0.38
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1356	1	1
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Schistosoma mansoni	tyrosine kinase	0.1356	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1356	1	1
Onchocerca volvulus		0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase shark	0.1356	1	1
Giardia lamblia	Protein 21.1	0.0781	0.5545	0.5
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0575	0.3947	0.38
Trichomonas vaginalis	CAMK family protein kinase	0.0781	0.5545	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0781	0.5545	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0781	0.5545	0.5545
Schistosoma mansoni	tyrosine protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	SH2 motif	0.0575	0.3947	0.38
Trypanosoma brucei	protein kinase, putative	0.0781	0.5545	1
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1356	1	1
Brugia malayi	Protein kinase domain containing protein	0.1356	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	tensin	0.0575	0.3947	0.38
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0781	0.5545	1
Brugia malayi	hypothetical protein	0.1356	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0781	0.5545	0.5437
Schistosoma mansoni	suppressor of cytokine signaling	0.0575	0.3947	0.38
Loa Loa (eye worm)	TK/Met protein kinase	0.0781	0.5545	0.5545
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0575	0.3947	0.38
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Schistosoma mansoni	serine/threonine protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0781	0.5545	0.5437
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	SHC transforming protein 3	0.0575	0.3947	0.38
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/DDR protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Echinococcus granulosus	growth factor receptor bound protein 2	0.0575	0.3947	0.38
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Schistosoma mansoni	protein kinase	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Schistosoma mansoni	nck2/grb4	0.0575	0.3947	0.38
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1356	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0781	0.5545	0.5437
Toxoplasma gondii	STE kinase	0.0781	0.5545	1
Echinococcus multilocularis	protein tyrosine kinase	0.0781	0.5545	0.5437
Brugia malayi	ephrin receptor 1 precursor	0.0781	0.5545	0.5437
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0575	0.3947	0.38
Onchocerca volvulus		0.1356	1	1
Leishmania major	hypothetical protein, conserved	0.0781	0.5545	1
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	epidermal growth factor receptor	0.0781	0.5545	0.5437
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0575	0.3947	0.3947
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0575	0.3947	0.38
Onchocerca volvulus		0.0781	0.5545	0.5437
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/INSR protein kinase	0.0781	0.5545	0.5545
Loa Loa (eye worm)	TK/FER protein kinase	0.1356	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0781	0.5545	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0575	0.3947	0.38
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0575	0.3947	0.38
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0781	0.5545	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0575	0.3947	0.3947
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0575	0.3947	0.38
Echinococcus granulosus	tyrosine kinase	0.1356	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0575	0.3947	0.38
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	SRC-1	0.1356	1	1
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Trichomonas vaginalis	conserved hypothetical protein	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Giardia lamblia	Kinase, NEK	0.0781	0.5545	0.5
Loa Loa (eye worm)	hypothetical protein	0.0781	0.5545	0.5545
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0781	0.5545	0.5437
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0781	0.5545	0.5545
Entamoeba histolytica	protein kinase, putative	0.0781	0.5545	0.5437
Schistosoma mansoni	tyrosine kinase	0.0781	0.5545	0.5437
Echinococcus multilocularis	tyrosine protein kinase	0.0781	0.5545	0.5437
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0781	0.5545	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Brugia malayi	Protein kinase domain containing protein	0.0781	0.5545	0.5437
Giardia lamblia	Kinase, NEK	0.0781	0.5545	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Entamoeba histolytica	protein kinase domain containing protein	0.0781	0.5545	0.5437
Brugia malayi	SH2 domain containing protein	0.0575	0.3947	0.38
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0781	0.5545	0.5437
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0781	0.5545	0.5545
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0781	0.5545	0.5437
Entamoeba histolytica	hypothetical protein	0.0781	0.5545	0.5437
Echinococcus multilocularis	N chimaerin	0.0575	0.3947	0.38
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0781	0.5545	0.5437
Brugia malayi	C-terminal src kinase protein 1	0.0781	0.5545	0.5437
Trichomonas vaginalis	TKL family protein kinase	0.0781	0.5545	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0781	0.5545	0.5437
Echinococcus granulosus	c src tyrosine kinase	0.1356	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
%max (binding)	= 33 %	Activation of glucokinase (unknown origin) relative to control	ChEMBL.	23434031
EC50 (binding)	= 0.063 uM	Activation of glucokinase (unknown origin)	ChEMBL.	23434031

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2346882

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1756794