Detailed information for compound 1757069

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 611.696 | Formula: C28H32F3N3O5S2
  • H donors: 2 H acceptors: 4 LogP: 4.69 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@@H](C)[C@@H](CN(Cc2ccc(cc2)C(F)(F)F)C)Oc2c(C1=O)cccc2NS(=O)(=O)c1cccs1)C
  • InChi: 1S/C28H32F3N3O5S2/c1-18-14-34(19(2)17-35)27(36)22-6-4-7-23(32-41(37,38)25-8-5-13-40-25)26(22)39-24(18)16-33(3)15-20-9-11-21(12-10-20)28(29,30)31/h4-13,18-19,24,32,35H,14-17H2,1-3H3/t18-,19-,24-/m1/s1
  • InChiKey: AHUZFXYFUYFNSB-KHCICDEESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.001 0.0007 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.001 0.0005
Schistosoma mansoni myosin xvIII 0.0011 0.001 0.0005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.001 0.0005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.001 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0094 0.0475
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0094 0.9031
Echinococcus granulosus epidermal growth factor receptor 0.012 0.0411 0.0406
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis 0.0034 0.0095 0.0089
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.001 0.0005
Schistosoma mansoni tyrosine kinase 0.0117 0.0399 0.0394
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.001 0.0005
Schistosoma mansoni histamine h1 receptor 0.0011 0.001 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0164 0.0159
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0103 0.0526
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0117 0.0399 0.0394
Loa Loa (eye worm) hypothetical protein 0.013 0.0448 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Echinococcus granulosus fmrfamide receptor 0.0011 0.001 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0052
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0263 0.0936 0.0931
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0026 0.0112
Brugia malayi ORL1-like opioid receptor 0.0011 0.001 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.0448 0.0443
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0063 0.0362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0164 0.0159
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.001 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.001 0.0005
Brugia malayi AKH receptor 0.0011 0.001 0.0005
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0032 0.1946
Schistosoma mansoni amine GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.001 0.0005
Brugia malayi CXXC zinc finger family protein 0.0025 0.0061 0.0055
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Plasmodium falciparum heterochromatin protein 1 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Brugia malayi chromobox protein homolog 3 0.0034 0.0094 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.001 0.0005
Echinococcus multilocularis sex peptide receptor 0.0011 0.001 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptide receptor 0.0011 0.001 0.0005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.001 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Brugia malayi CHD4 protein 0.0011 0.001 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.001 0.0005
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.001 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis protein tyrosine kinase 0.0248 0.0881 0.0876
Echinococcus granulosus serotonin receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.001 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus sex peptide receptor 0.0011 0.001 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Schistosoma mansoni adenoreceptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.001 0.0005
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.001 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0094 0.0475
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Schistosoma mansoni neuropeptide receptor 0.0011 0.001 0.0005
Echinococcus granulosus cpg binding protein 0.0026 0.0066 0.0061
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.006
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.001 0.0005
Brugia malayi Dopamine receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) TK/FAK protein kinase 0.0251 0.0891 0.0891
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.001 0.0005
Onchocerca volvulus 0.001 0.0007 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus somatostatin receptor 0.0011 0.001 0.0005
Plasmodium vivax heterochromatin protein 1, putative 0.001 0.0005 0.5
Plasmodium vivax hypothetical protein, conserved 0.001 0.0005 0.5
Schistosoma mansoni neuropeptide receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) heterochromatin protein 1 0.0061 0.0192 0.0192
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0063 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0192 0.1001
Loa Loa (eye worm) hypothetical protein 0.0143 0.0494 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Brugia malayi neuropeptide F receptor 0.0011 0.001 0.0005
Brugia malayi GnHR receptor homolog 0.0011 0.001 0.0005
Echinococcus multilocularis chromobox protein 1 0.0061 0.0192 0.0187
Brugia malayi Serotonin receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Giardia lamblia Fructose-bisphosphate aldolase 0.0517 0.1869 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.001 0.0005
Brugia malayi RE15519p 0.0011 0.001 0.0005
Echinococcus granulosus g protein coupled receptor 0.0011 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.2729 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.001 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.001 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.001 0.0005
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.001 0.001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.001 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Schistosoma mansoni opsin-like receptor 0.0011 0.001 0.0005
Echinococcus multilocularis serotonin receptor 0.013 0.0448 0.0443
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.001 0.0005
Brugia malayi Heterochromatin protein 1 0.0061 0.0192 0.0187
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.001 0.0005
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.001 0.0005
Schistosoma mansoni neuropeptide receptor 0.0011 0.001 0.0005
Echinococcus granulosus insulin receptor 0.0263 0.0936 0.0931
Leishmania major cytochrome p450-like protein 0.0026 0.0063 1
Schistosoma mansoni neuropeptide receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) cytochrome P450 0.0017 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0027
Brugia malayi Protein kinase domain containing protein 0.0263 0.0936 0.0931
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0164 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0253 0.0897 1
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus g protein coupled receptor 0.0011 0.001 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0011 0.001 0.0005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0253 0.0897 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0164 0.0159
Schistosoma mansoni opsin-like receptor 0.0011 0.001 0.0005
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0253 0.0897 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0164 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0103 0.0526
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.001 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.001 0.0005
Treponema pallidum fructose-bisphosphate aldolase 0.0517 0.1869 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.001 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus allatostatin A receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0164 0.0159
Schistosoma mansoni amine GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.0026 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Schistosoma mansoni tyrosine kinase 0.0248 0.0881 0.0876
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.012 0.0411 0.0406
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.001 0.0005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.001 0.0005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.001 0.0005
Schistosoma mansoni chromobox protein 0.0061 0.0192 0.0187
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0117 0.0399 0.0394
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0063 1
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.001 0.0005
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0517 0.1869 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Echinococcus multilocularis g protein coupled receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.001 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.001 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.001 0.0005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.001 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0164 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Schistosoma mansoni opsin-like receptor 0.0011 0.001 0.0005
Schistosoma mansoni biogenic amine receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.2729 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.012 0.0411 0.0406
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.001 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0164 0.0159
Schistosoma mansoni cpg binding protein 0.0025 0.0061 0.0055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0026 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus orexin receptor type 2 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus chromobox protein 1 0.0061 0.0192 0.0187
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.001 0.001
Brugia malayi sulfakinin receptor protein 0.0011 0.001 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni chromobox protein 0.0061 0.0192 0.0187
Echinococcus multilocularis chromobox protein 1 0.0061 0.0192 0.0187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.001 0.0005
Brugia malayi G protein-coupled receptor 0.0011 0.001 0.0005
Brugia malayi cytochrome P450 0.0017 0.0032 0.0027
Schistosoma mansoni tyrosine kinase 0.0263 0.0936 0.0931
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0032 0.0027
Onchocerca volvulus 0.0025 0.0061 0.5656
Schistosoma mansoni tyrosine kinase 0.012 0.0411 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Brugia malayi putative neuropeptide receptor 0.0011 0.001 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Schistosoma mansoni amine GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.001 0.0005
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.012 0.0411 0.0406
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.0448 0.0443
Echinococcus granulosus neuropeptide s receptor 0.0011 0.001 0.0005
Echinococcus granulosus hypothetical protein 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.001 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.001 0.0005
Echinococcus granulosus g protein coupled receptor 0.0011 0.001 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0192 0.1001
Brugia malayi Protein kinase domain containing protein 0.0146 0.0505 0.05
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.001 0.001
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.2729 1 1
Brugia malayi Serotonin receptor 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.001 0.0005
Schistosoma mansoni cpg binding protein 0.0026 0.0066 0.0061
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0063 1
Schistosoma mansoni biogenic amine receptor 0.0011 0.001 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Brugia malayi G-protein coupled receptor 0.0011 0.001 0.0005
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.001 0.0475
Brugia malayi Cytochrome P450 family protein 0.0026 0.0063 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) helicase 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.001 0.0005 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.001 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.006
Echinococcus multilocularis 0.0017 0.0032 0.0027
Brugia malayi Cytochrome P450 family protein 0.0026 0.0063 0.0058
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Brugia malayi larval opioid receptor 0.0011 0.001 0.0005
Brugia malayi Dopamine receptor protein 2 0.0011 0.001 0.0005
Brugia malayi Furin-like cysteine rich region family protein 0.012 0.0411 0.0406
Echinococcus granulosus protein tyrosine kinase 0.0248 0.0881 0.0876
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Echinococcus multilocularis fmrfamide receptor 0.0011 0.001 0.0005
Brugia malayi Cytochrome P450 family protein 0.0054 0.0168 0.0163
Brugia malayi Cytochrome P450 family protein 0.0017 0.0032 0.0027
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0005
Echinococcus multilocularis insulin receptor 0.0263 0.0936 0.0931
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0061 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Schistosoma mansoni amine GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0011 0.001 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.001 0.0005
Brugia malayi G-protein coupled receptor 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.001 0.0005
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.2729 1 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.001 0.0005 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.012 0.0411 0.0406
Onchocerca volvulus 0.0011 0.001 0.0475
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0047 0.0143 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.012 0.0411 0.0411
Brugia malayi Dopamine receptor protein 1 0.0011 0.001 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.001 0.0005
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.001 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0067
Echinococcus granulosus epidermal growth factor receptor 0.012 0.0411 0.0406
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0517 0.1869 1
Brugia malayi Melatonin receptor type 1A 0.0011 0.001 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.001 0.0005
Schistosoma mansoni biogenic amine receptor 0.0011 0.001 0.0005
Schistosoma mansoni amine GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0251 0.0891 0.0887
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.001 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.001 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.001 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0057 0.0279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0164 0.0164
Schistosoma mansoni tyrosine kinase 0.012 0.0411 0.0406
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.001 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0164 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.001 0.001
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.001 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.001 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.001 0.0005
Echinococcus granulosus g-protein coupled receptor 0.0011 0.001 0.0005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.001 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0263 0.0936 0.0936
Echinococcus granulosus chromobox protein 1 0.0061 0.0192 0.0187
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.001 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.001 0.0005
Schistosoma mansoni cytochrome P450 0.0017 0.0032 0.0027
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.001 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Echinococcus multilocularis orexin receptor type 2 0.0011 0.001 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0026 0.0112
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.001 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Echinococcus multilocularis serotonin receptor 0.013 0.0448 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.001 0.0005
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.001 0.0005
Echinococcus multilocularis somatostatin receptor 0.0011 0.001 0.0005
Brugia malayi neuropeptide F receptor 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptide receptor 0.0011 0.001 0.0005
Brugia malayi hypothetical protein 0.0011 0.001 0.0005
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.001 0.0005
Schistosoma mansoni tyrosine kinase 0.0263 0.0936 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0057 0.0279
Loa Loa (eye worm) hypothetical protein 0.013 0.0448 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.001 0.0005
Onchocerca volvulus 0.0011 0.001 0.0475
Echinococcus multilocularis neuropeptide receptor 0.0011 0.001 0.0005
Schistosoma mansoni cpg binding protein 0.0026 0.0066 0.0061
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0263 0.0936 0.0931
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0517 0.1869 1
Onchocerca volvulus 0.0027 0.0067 0.6276
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.001 0.0005 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.001
Brugia malayi SET domain containing protein 0.001 0.0007 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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