Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D1 receptor | 446 aa | 370 aa | 24.9 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Dopamine D1 receptor | 446 aa | 394 aa | 29.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D1 receptor | 446 aa | 373 aa | 25.5 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D1 receptor | 446 aa | 366 aa | 35.2 % |
Onchocerca volvulus | Dopamine D1 receptor | 446 aa | 357 aa | 21.0 % | |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine D1 receptor | 446 aa | 407 aa | 33.7 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.7978 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2659 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine kinase | 0.7978 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2659 | 0.0037 | 0.0037 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2659 | 0.0037 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2659 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2659 | 0.0037 | 0.0037 |
Echinococcus multilocularis | calcium activated potassium channel | 0.2659 | 0.0037 | 0.0074 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.5339 | 0.5056 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2659 | 0.0037 | 0.0074 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.5339 | 0.5056 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.7978 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2659 | 0.0037 | 0.0037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.071 nM | Binding affinity against Dopamine receptor D2 from rat brain corpus striatum membrane | ChEMBL. | 2147956 |
IC50 (binding) | = 0.071 nM | Displacement of [3H]raclopride from rat dopamine D2 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 0.071 nM | Binding affinity against Dopamine receptor D2 from rat brain corpus striatum membrane | ChEMBL. | 2147956 |
IC50 (binding) | = 0.071 nM | Displacement of [3H]raclopride from rat dopamine D2 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 1300 nM | Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane | ChEMBL. | 2147956 |
IC50 (binding) | = 1300 nM | Displacement of [3H]SCH23390 from rat dopamine D1 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 1300 nM | Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane | ChEMBL. | 2147956 |
IC50 (binding) | = 1300 nM | Displacement of [3H]SCH23390 from rat dopamine D1 receptor | ChEMBL. | 17228858 |
Ki (binding) | Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assay | ChEMBL. | 21666830 | |
Ki (binding) | = 2.7 nM | Displacement of [3H]domperidone from dopamine D2 receptor high binding site in Sprague-Dawley rat striatum by scintillation counting | ChEMBL. | 21666830 |
Ki (binding) | = 3.8 nM | Displacement of [3H]domperidone from human cloned dopamine D3 receptor high binding site expressed in mouse CCL1-3 cells by scintillation counting | ChEMBL. | 21666830 |
Ki (binding) | = 1800 nM | Displacement of [3H]SCH23390 from dopamine D2 receptor low binding site in Sprague-Dawley rat striatum by scintillation counting | ChEMBL. | 21666830 |
Ki (binding) | > 5000 nM | Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assay | ChEMBL. | 21666830 |
Ki (binding) | > 10 uM | Displacement of [3H]domperidone from human cloned dopamine D3 receptor expressed in mouse CCL1-3 cells by scintillation counting | ChEMBL. | 21666830 |
Potency ratio (binding) | = 18300 | Potency ratio of the compound was determined as ratio of IC50 of D2 receptor to that of D1 receptor | ChEMBL. | 2147956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.