Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0084 | 0.3801 | 0.5551 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.007 | 0.2845 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.007 | 0.2845 | 0.4155 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.013 | 0.6848 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0073 | 0.3012 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0058 | 0.2014 | 0.2941 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0092 | 0.4339 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0063 | 0.2345 | 0.3424 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0087 | 0.3979 | 0.581 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0073 | 0.3012 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0035 | 0.0524 | 0.0765 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0157 | 0.8635 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0058 | 0.2014 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0092 | 0.4339 | 0.6337 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.013 | 0.6848 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0092 | 0.4339 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0087 | 0.3979 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0087 | 0.3979 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0087 | 0.3979 | 0.581 |
Echinococcus multilocularis | geminin | 0.0177 | 1 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0081 | 0.3598 | 0.4129 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0092 | 0.4339 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0049 | 0.1476 | 0.2155 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0165 | 0.9173 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0087 | 0.3979 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0073 | 0.3012 | 0.4398 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.013 | 0.6848 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0086 | 0.3901 | 0.4542 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0092 | 0.4339 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0062 | 0.2307 | 0.3708 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1656 | 0.1494 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0092 | 0.4339 | 0.6337 |
Loa Loa (eye worm) | acyl carrier protein | 0.004 | 0.0845 | 0.0393 |
Mycobacterium ulcerans | polyketide synthase | 0.0092 | 0.4339 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0087 | 0.3979 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.007 | 0.2845 | 0.4155 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1656 | 0.1494 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.013 | 0.6848 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0087 | 0.3979 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1428 | 0.1184 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0092 | 0.4339 | 0.6337 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0092 | 0.4339 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0058 | 0.2014 | 0.2941 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0087 | 0.3979 | 0.581 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0081 | 0.3598 | 0.5254 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1656 | 0.1277 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0087 | 0.3979 | 0.581 |
Onchocerca volvulus | 0.0151 | 0.8274 | 0.9285 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1656 | 0.1277 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0081 | 0.3598 | 0.353 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0084 | 0.3801 | 0.5551 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0056 | 0.1941 | 0.2574 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0073 | 0.3012 | 0.4398 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0087 | 0.3979 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7923 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.003 | 0.0172 | 0.0251 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0071 | 0.2922 | 0.4267 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0092 | 0.4339 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0087 | 0.3979 | 0.3973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.