Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0223 | 0.3995 | 0.5463 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0237 | 0.4411 | 0.6033 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.8555 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0237 | 0.4411 | 0.5226 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0223 | 0.3995 | 0.454 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0256 | 0.4988 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0223 | 0.3995 | 0.454 |
Brugia malayi | AMP-binding enzyme family protein | 0.0208 | 0.3554 | 0.3193 |
Mycobacterium ulcerans | polyketide synthase | 0.0223 | 0.3995 | 0.454 |
Mycobacterium ulcerans | thioesterase TesA | 0.0186 | 0.2877 | 0.27 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0148 | 0.1723 | 0.0801 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.016 | 0.2106 | 0.288 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1236 | 0.1057 |
Onchocerca volvulus | Matrilysin homolog | 0.0239 | 0.4478 | 0.4463 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0237 | 0.4411 | 0.5226 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0237 | 0.4411 | 0.6033 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0208 | 0.3554 | 0.4861 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.053 | 0.0193 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0108 | 0.053 | 0.0193 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0333 | 0.7312 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0392 | 0.9075 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0216 | 0.3789 | 0.5182 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0145 | 0.1639 | 0.2574 |
Brugia malayi | Hemopexin family protein | 0.0153 | 0.1885 | 0.1431 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0237 | 0.4411 | 0.5226 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0333 | 0.7312 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0223 | 0.3995 | 0.454 |
Brugia malayi | Matrixin family protein | 0.0261 | 0.5127 | 0.4854 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0237 | 0.4411 | 0.6033 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0237 | 0.4411 | 0.5226 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.1885 | 0.3039 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.018 | 0.2684 | 0.2383 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0333 | 0.7312 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.018 | 0.2684 | 0.2383 |
Onchocerca volvulus | 0.0153 | 0.1885 | 0.1531 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0239 | 0.4478 | 0.4463 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0148 | 0.1723 | 0.0801 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0392 | 0.9075 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0239 | 0.4478 | 0.5018 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0186 | 0.2877 | 0.3934 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.053 | 0.0193 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0223 | 0.3995 | 0.454 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0237 | 0.4411 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0237 | 0.4411 | 0.5226 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0223 | 0.3995 | 0.3659 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0216 | 0.3789 | 0.5182 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0131 | 0.1236 | 0.1691 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0223 | 0.3995 | 0.454 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0182 | 0.2773 | 0.3792 |
Onchocerca volvulus | 0.0208 | 0.3554 | 0.3418 | |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0159 | 0.2062 | 0.3708 |
Mycobacterium ulcerans | polyketide synthase | 0.0237 | 0.4411 | 0.5226 |
Loa Loa (eye worm) | fatty acid synthase | 0.022 | 0.3905 | 0.4318 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0148 | 0.1723 | 0.0801 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0402 | 0.9378 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0208 | 0.3554 | 0.3889 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0223 | 0.3995 | 0.454 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1046 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.053 | 0.0193 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0186 | 0.2877 | 0.27 |
Loa Loa (eye worm) | matrixin family protein | 0.0261 | 0.5127 | 0.5811 |
Mycobacterium ulcerans | thioesterase | 0.0186 | 0.2877 | 0.27 |
Onchocerca volvulus | 0.0388 | 0.8961 | 0.9529 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0223 | 0.3995 | 0.5463 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.018 | 0.2684 | 0.2383 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0333 | 0.7312 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0223 | 0.3995 | 0.5463 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0127 | 0.1101 | 0.1505 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0131 | 0.1236 | 0.0746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.