Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X3-C motif) receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-X-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0538 | 0.3948 | 0.3948 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0575 | 0.4361 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.041 | 0.2547 | 0.3708 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0611 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0181 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0558 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | thioesterase | 0.0479 | 0.3311 | 0.443 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0373 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0463 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0558 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0575 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0198 | 0.0229 | 0.0306 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0538 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0575 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | thioesterase TesA | 0.0479 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0575 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0538 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.086 | 0.7476 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.086 | 0.7476 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0575 | 0.4361 | 0.4361 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.047 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.038 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.086 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.038 | 0.2228 | 0.2941 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0181 | 0.0042 | 0.0056 |
Onchocerca volvulus | 0.1001 | 0.9025 | 0.9285 | |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1037 | 0.9416 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0327 | 0.1644 | 0.2199 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0575 | 0.4361 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0611 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase | 0.0575 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0479 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0233 | 0.061 | 0.0817 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1592 | 0.0823 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0463 | 0.3131 | 0.4155 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0575 | 0.4361 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0463 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0479 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.038 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0575 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0575 | 0.4361 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0611 | 0.4752 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.086 | 0.7476 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0611 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.8643 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0568 | 0.4277 | 0.4318 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0413 | 0.2588 | 0.3461 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0611 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0575 | 0.4361 | 0.5834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 64 nM | Displacement of [125I]-IL8 from human CXCR2 transfected in HEK293 cells after 4 hrs by microbeta counting analysis | ChEMBL. | 23516963 |
Ki (binding) | = 360 nM | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis | ChEMBL. | 23516963 |
Papp (ADMET) | = 1.6 ucm/s | Apparent permeability from apical to basolateral side in human Caco2 cells at pH 6.5 after 90 mins by LC-MS analysis | ChEMBL. | 23516963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.