Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.006 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0053 | 0.3922 | 0.5254 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.006 | 0.473 | 0.6337 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.006 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0041 | 0.2556 | 0.3424 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0047 | 0.3185 | 0.4267 |
Mycobacterium ulcerans | thioesterase | 0.0047 | 0.3283 | 0.4398 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0037 | 0.2116 | 0.2574 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.006 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0032 | 0.1609 | 0.2155 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0038 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0046 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0057 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.006 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0038 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0085 | 0.7465 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0057 | 0.4337 | 0.581 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0085 | 0.7465 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.006 | 0.473 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0103 | 0.9413 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0047 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0053 | 0.3922 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.8637 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0057 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0023 | 0.0571 | 0.0765 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0055 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0057 | 0.4337 | 0.581 |
Onchocerca volvulus | 0.0099 | 0.9021 | 0.9285 | |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0085 | 0.7465 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0046 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0047 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0057 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.002 | 0.0188 | 0.0251 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0057 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.006 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0055 | 0.4144 | 0.5551 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0057 | 0.4337 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0057 | 0.4337 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1557 | 0.0823 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0046 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0085 | 0.7465 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0057 | 0.4337 | 0.0684 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.006 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0057 | 0.4337 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.006 | 0.473 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0041 | 0.2515 | 0.3708 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.006 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0038 | 0.2195 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0057 | 0.4337 | 0.581 |
Loa Loa (eye worm) | fatty acid synthase | 0.0056 | 0.4253 | 0.4318 |
Mycobacterium ulcerans | thioesterase TesA | 0.0047 | 0.3283 | 0.4398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.