TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.435 | Formula: C16H13N5O5S2
H donors: 3 H acceptors: 6 LogP: 3.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(sc1C(=O)c1ccc(cc1)[N+](=O)[O-])Nc1ccc(cc1)S(=O)(=O)N
InChi: 1S/C16H13N5O5S2/c17-15-14(13(22)9-1-5-11(6-2-9)21(23)24)27-16(20-15)19-10-3-7-12(8-4-10)28(18,25)26/h1-8H,17H2,(H,19,20)(H2,18,25,26)
InChiKey: MJQJZIFYLHKLRH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin A2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania infantum	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Onchocerca volvulus		Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei gambiense	cyclin 6,mitotic cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Entamoeba histolytica	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin A, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium parvum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium hominis	mitotic cyclin-CYC2	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Giardia lamblia	G2/mitotic-specific cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	ankyrin repeat protein	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0066	0.4953	0.4953
Echinococcus granulosus	natriuretic peptide receptor 1	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.011	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Src42A	0.011	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus multilocularis		0.0066	0.4953	0.3815
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Giardia lamblia	Kinase	0.0044	0.2474	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0044	0.2474	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine kinase	0.011	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/CSK protein kinase	0.0044	0.2474	0.2474
Echinococcus multilocularis	activated cdc42 kinase 1	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Onchocerca volvulus		0.0066	0.4953	0.3815
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0044	0.2474	0.0777
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Srms	0.011	1	1
Entamoeba histolytica	protein kinase, putative	0.0066	0.4953	0.3815
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0066	0.4953	0.3815
Schistosoma mansoni	adapter molecule crk	0.0066	0.4953	0.3815
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0066	0.4953	0.3815
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0066	0.4953	0.4953
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0066	0.4953	0.3815
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Brugia malayi	hypothetical protein	0.011	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0044	0.2474	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0044	0.2474	0.5
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Brugia malayi	SH2 domain containing protein	0.011	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.4953	0.3815
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0044	0.2474	1
Brugia malayi	hypothetical protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.011	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.011	1	1
Echinococcus granulosus	SH2 motif	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	integrin linked protein kinase	0.0044	0.2474	0.0777
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0044	0.2474	0.0777
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0066	0.4953	0.3815
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0066	0.4953	0.3815
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	STE family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus granulosus	SH2 motif	0.0066	0.4953	0.3815
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.4953	0.3815
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine kinase	0.011	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Giardia lamblia	Kinase, NEK	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.4953	0.3815
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.4953	0.3815
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0044	0.2474	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0044	0.2474	0.0777
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Echinococcus multilocularis	tyrosine protein kinase Abl	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Onchocerca volvulus		0.011	1	1
Plasmodium falciparum	protein kinase, putative	0.0044	0.2474	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0044	0.2474	0.0777
Echinococcus granulosus	growth factor receptor bound protein 2	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.011	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Echinococcus granulosus	integrin linked protein kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0066	0.4953	0.3815
Schistosoma mansoni	tensin	0.0066	0.4953	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1839	0.1839
Trypanosoma cruzi	protein kinase, putative	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0066	0.4953	0.3815
Brugia malayi	Receptor family ligand binding region containing protein	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.011	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.011	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0066	0.4953	0.3815
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Schistosoma mansoni	hypothetical protein	0.0066	0.4953	0.3815
Echinococcus granulosus	protein tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	hypothetical protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	signal transduction protein lnk realted	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	N chimaerin	0.0066	0.4953	0.3815
Echinococcus multilocularis	NCK adaptor protein	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	SRC-1	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	SRC-1	0.011	1	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosin kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/ALK protein kinase	0.0044	0.2474	0.2474
Echinococcus granulosus	tyrosine protein kinase HCK	0.0044	0.2474	0.0777
Leishmania major	protein kinase, putative	0.0044	0.2474	1
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	hypothetical protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	SH2 domain containing protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	SH2 motif	0.0066	0.4953	0.3815
Onchocerca volvulus		0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0066	0.4953	0.3815
Schistosoma mansoni	signal transduction protein lnk-related	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	protein kinase atn1, putative	0.0044	0.2474	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0044	0.2474	0.0777
Brugia malayi	Tyrosine-protein kinase PR2	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	activin receptor type	0.0044	0.2474	0.0777
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0044	0.2474	0.0777
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Onchocerca volvulus		0.011	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Trichomonas vaginalis	TK family protein kinase	0.0044	0.2474	1
Brugia malayi	integrin-linked kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.011	1	1
Onchocerca volvulus		0.011	1	1
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0044	0.2474	0.2474
Onchocerca volvulus		0.011	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	epidermal growth factor receptor	0.0044	0.2474	0.0777
Echinococcus granulosus	raf serine:threonine protein kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus granulosus	protein kinase	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0044	0.2474	0.2474
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	ephrin receptor	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tensin	0.0066	0.4953	0.3815
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.011	1	1
Echinococcus multilocularis	tensin	0.0066	0.4953	0.3815
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0044	0.2474	0.0777
Onchocerca volvulus		0.0044	0.2474	0.0777
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/Met protein kinase	0.0044	0.2474	0.2474
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0044	0.2474	1
Entamoeba histolytica	hypothetical protein, conserved	0.0044	0.2474	0.0777
Schistosoma mansoni	vav2	0.0066	0.4953	0.3815
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0044	0.2474	1
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0044	0.2474	0.2474
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0044	0.2474	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase pr2	0.0044	0.2474	0.0777
Schistosoma mansoni	SH2A	0.0066	0.4953	0.3815
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	ephrin receptor	0.0044	0.2474	0.0777
Brugia malayi	Raf kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	activated cdc42 kinase 1	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	protein-tyrosine kinase	0.011	1	1
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	cyclins, putative	0.0039	0.1839	0.6876
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Echinococcus granulosus	activated cdc42 kinase 1	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Src64B	0.011	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	FL cytokine receptor	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0066	0.4953	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0044	0.2474	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0044	0.2474	0.2474
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tensin-related	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	transfer RNA-Thr	0.0044	0.2474	0.0777
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0044	0.2474	0.0777
Leishmania major	hypothetical protein, conserved	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Lyn	0.011	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus granulosus	N chimaerin	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine kinase	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	nck2/grb4	0.0066	0.4953	0.3815
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0066	0.4953	0.4953
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0044	0.2474	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0044	0.2474	0.2474
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Brugia malayi	Tensin	0.0066	0.4953	0.3815
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Schistosoma mansoni	protein tyrosine kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosin kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Echinococcus granulosus	insulin receptor	0.0044	0.2474	0.0777
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	protein kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1839	0.1839
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Echinococcus granulosus	SHC transforming protein 3	0.0066	0.4953	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Schistosoma mansoni	tensin	0.0066	0.4953	0.3815
Echinococcus granulosus	c src tyrosine kinase	0.011	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0066	0.4953	0.3815
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Leishmania major	protein kinase, putative	0.0044	0.2474	1
Onchocerca volvulus		0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0044	0.2474	0.0777
Echinococcus multilocularis	epidermal growth factor receptor	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0044	0.2474	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.011	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0044	0.2474	0.0777
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0066	0.4953	0.3815
Loa Loa (eye worm)	TK/ABL protein kinase	0.011	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0066	0.4953	0.3815
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Onchocerca volvulus		0.011	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0044	0.2474	0.0777
Trichomonas vaginalis	cyclins, putative	0.0039	0.1839	0.6876
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0066	0.4953	0.4953
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	ephrin receptor 1 precursor	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Brugia malayi	RhoGAP domain containing protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.011	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	heat shock protein 70	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase shark	0.011	1	1
Giardia lamblia	Kinase, NEK	0.0044	0.2474	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0066	0.4953	0.3815
Loa Loa (eye worm)	TK protein kinase	0.011	1	1
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Plasmodium falciparum	tyrosine kinase-like protein	0.0044	0.2474	0.5
Brugia malayi	hypothetical protein	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase ABL1	0.011	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus granulosus	ephrin type A receptor 4 A	0.0044	0.2474	0.0777
Echinococcus multilocularis	SH2 motif	0.0066	0.4953	0.3815
Schistosoma mansoni	shc transforming protein	0.0066	0.4953	0.3815
Trichomonas vaginalis	cyclins, putative	0.0039	0.1839	0.6876
Brugia malayi	SH2 domain containing protein	0.011	1	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	cyclin B, putative	0.0039	0.1839	0.6876
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0066	0.4953	0.3815
Onchocerca volvulus		0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	GTPase activating protein	0.0066	0.4953	0.3815
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Toxoplasma gondii	STE kinase	0.0044	0.2474	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0044	0.2474	0.0777
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0066	0.4953	0.3815
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0044	0.2474	0.2474
Loa Loa (eye worm)	TK/ACK protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0044	0.2474	0.0777
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.011	1	1
Schistosoma mansoni	hypothetical protein	0.0066	0.4953	0.3815
Schistosoma mansoni	tensin	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	cyclin B, putative	0.0039	0.1839	0.6876
Echinococcus multilocularis	SHC transforming protein 3	0.0066	0.4953	0.3815
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Echinococcus multilocularis	insulin receptor	0.0044	0.2474	0.0777
Onchocerca volvulus	Tyrosine kinase homolog	0.0044	0.2474	0.0777
Echinococcus multilocularis	SH2 motif	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0066	0.4953	0.3815
Trichomonas vaginalis	CAMK family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	tensin	0.0066	0.4953	0.3815
Onchocerca volvulus		0.0066	0.4953	0.3815
Echinococcus granulosus	activin receptor type	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0044	0.2474	0.0777
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0044	0.2474	0.0777
Trypanosoma cruzi	protein kinase, putative	0.0044	0.2474	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Entamoeba histolytica	tyrosin kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	hypothetical protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/ROR protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	tensin-related	0.0066	0.4953	0.3815
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0044	0.2474	0.0777
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0044	0.2474	0.0777
Trypanosoma brucei	Pseudokinase, putative	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0044	0.2474	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Onchocerca volvulus		0.0066	0.4953	0.3815
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0066	0.4953	0.4953
Brugia malayi	C-terminal src kinase protein 1	0.0044	0.2474	0.0777
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase Srms	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0044	0.2474	0.2474
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0044	0.2474	0.0777
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0066	0.4953	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase shark	0.011	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	STAT protein	0.0066	0.4953	0.4953
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Plasmodium falciparum	protein kinase, putative	0.0044	0.2474	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.011	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.011	1	1
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0066	0.4953	0.3815
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Toxoplasma gondii	protein kinase	0.0044	0.2474	0.5
Onchocerca volvulus		0.0066	0.4953	0.3815
Loa Loa (eye worm)	SH2 domain-containing protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0044	0.2474	0.2474
Trichomonas vaginalis	cyclins, putative	0.0039	0.1839	0.6876
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0044	0.2474	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Onchocerca volvulus		0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/EPH protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	protein kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK protein kinase	0.0044	0.2474	0.2474
Echinococcus multilocularis	c src tyrosine kinase	0.011	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0044	0.2474	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0044	0.2474	0.0777
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.2474	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0044	0.2474	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0066	0.4953	0.4953
Onchocerca volvulus		0.011	1	1
Giardia lamblia	Protein 21.1	0.0044	0.2474	1
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	hypothetical protein	0.0044	0.2474	0.0777
Schistosoma mansoni	suppressor of cytokine signaling	0.0066	0.4953	0.3815
Trichomonas vaginalis	cyclin A, putative	0.0039	0.1839	0.6876
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Echinococcus multilocularis	protein kinase	0.0044	0.2474	0.0777
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.011	1	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Trichomonas vaginalis	cyclin B, putative	0.0039	0.1839	0.6876
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0044	0.2474	0.2474
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.011	1	1
Entamoeba histolytica	cysteine surface protein, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2474	0.2474
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0044	0.2474	0.0777
Trichomonas vaginalis	AGC family protein kinase	0.0044	0.2474	1
Echinococcus granulosus	expressed conserved protein	0.0066	0.4953	0.3815
Trypanosoma brucei	protein kinase, putative	0.0044	0.2474	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0066	0.4953	0.3815
Echinococcus granulosus	tyrosine kinase	0.0044	0.2474	0.0777
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.4953	0.3815
Schistosoma mansoni	serine/threonine RGC	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Brugia malayi	Guanylyl cyclase protein 23	0.0044	0.2474	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0044	0.2474	0.0777
Brugia malayi	SH2 domain containing protein	0.0066	0.4953	0.3815
Echinococcus granulosus	receptor type guanylyl cyclase	0.0044	0.2474	0.0777
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0044	0.2474	1
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.2474	0.0777
Entamoeba histolytica	receptor protein kinase, putative	0.0044	0.2474	0.0777
Entamoeba histolytica	serine/threonine kinase, putative	0.0044	0.2474	0.0777
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0044	0.2474	0.0777
Toxoplasma gondii	protein kinase domain-containing protein	0.0044	0.2474	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/RYK protein kinase	0.0044	0.2474	0.2474
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0044	0.2474	0.0777
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0066	0.4953	0.3815
Echinococcus multilocularis	tyrosine protein kinase csk	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0066	0.4953	0.3815
Loa Loa (eye worm)	SH2 domain-containing protein	0.0066	0.4953	0.4953
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0066	0.4953	0.3815
Schistosoma mansoni	tyrosine kinase	0.0044	0.2474	0.0777
Entamoeba histolytica	receptor protein kinase, putative	0.0044	0.2474	0.0777
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.4953	0.4953
Plasmodium vivax	protein kinase, putative	0.0044	0.2474	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0044	0.2474	1
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0066	0.4953	0.4953
Entamoeba histolytica	tyrosine kinase, putative	0.0044	0.2474	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0044	0.2474	1
Trichomonas vaginalis	cyclin B, putative	0.0039	0.1839	0.6876
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.2474	0.2474
Plasmodium falciparum	protein kinase, putative	0.0044	0.2474	0.5
Echinococcus granulosus	NCK adaptor protein	0.0066	0.4953	0.3815

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.4 uM	Inhibition of human CDK2/Cyclin A2 using PKTPKKAKKL as substrate by PK/LDH spectrophotometric analysis	ChEMBL.	23600925

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2377812

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1760226