TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 296.407 | Formula: C19H24N2O
H donors: 0 H acceptors: 1 LogP: 2.82 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@@]12CCCN3C42[C@@H](CC3)c2c(N4C(=O)CC1)cccc2
InChi: 1S/C19H24N2O/c1-2-18-10-5-12-20-13-9-15-14-6-3-4-7-16(14)21(19(15,18)20)17(22)8-11-18/h3-4,6-7,15H,2,5,8-13H2,1H3/t15-,18+,19?/m0/s1
InChiKey: BUDRLZGHZYGRIQ-APBAKZIRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.4483	0.4505
Schistosoma mansoni	serine/threonine RGC	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/CSK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0074	0.4483	0.4505
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0074	0.4483	0.3194
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Plasmodium vivax	protein kinase, putative	0.005	0.1894	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0124	0.9951	0.9939
Brugia malayi	Furin-like cysteine rich region family protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0074	0.4483	0.4505
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.4483	0.4505
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Echinococcus multilocularis	tensin	0.0074	0.4483	0.3213
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	MH2 domain containing protein	0.0115	0.8947	0.8991
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Echinococcus granulosus	tyrosine kinase	0.0124	0.9951	0.9939
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Giardia lamblia	Kinase, NEK	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0074	0.4483	0.3194
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	ephrin receptor 1 precursor	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Echinococcus multilocularis	SH2 motif	0.0074	0.4483	0.3213
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.005	0.1943	0.0061
Echinococcus multilocularis	dual specificity mitogen activated protein	0.012	0.9518	0.9463
Onchocerca volvulus		0.0124	0.9951	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.005	0.1894	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0074	0.4483	0.3194
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.4483	0.4505
Onchocerca volvulus		0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	protein kinase	0.005	0.1943	0.1953
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	SH2 domain containing protein	0.0124	0.9951	1
Echinococcus multilocularis	tyrosine kinase	0.0124	0.9951	1
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0124	0.9951	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.0124	0.9951	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TK family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0124	0.9951	1
Onchocerca volvulus		0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	hypothetical protein	0.0124	0.9951	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0124	0.9951	0.9939
Brugia malayi	SRC-1	0.0124	0.9951	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1894	0.1903
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	ephrin receptor	0.005	0.1894	0.1903
Echinococcus granulosus	SH2 motif	0.0074	0.4483	0.3194
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.4483	0.4505
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0124	0.9951	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1654	0.1662
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Onchocerca volvulus		0.0124	0.9951	1
Schistosoma mansoni	tensin	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK/RYK protein kinase	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	protein kinase atn1, putative	0.005	0.1894	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0124	0.9951	0.9939
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	STAT protein	0.0074	0.4483	0.4505
Plasmodium falciparum	protein kinase, putative	0.005	0.1943	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Brugia malayi	Raf kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1654	0.1662
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0124	0.9951	1
Echinococcus granulosus	SHC transforming protein 3	0.0074	0.4483	0.3194
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0074	0.4483	0.3213
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Entamoeba histolytica	protein kinase, putative	0.0074	0.4532	0.3274
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0124	0.9951	1
Brugia malayi	Tyrosine-protein kinase PR2	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Brugia malayi	protein-tyrosine kinase	0.0124	0.9951	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tensin-related	0.0074	0.4483	0.4505
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0074	0.4483	0.3194
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.8947	0.8991
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.1894	0.1903
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.005	0.1943	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.005	0.1894	0.1903
Brugia malayi	SH2 domain containing protein	0.0124	0.9951	1
Echinococcus granulosus	expressed conserved protein	0.0074	0.4483	0.3194
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Schistosoma mansoni	protein kinase	0.005	0.1943	0.1953
Schistosoma mansoni	protein kinase	0.005	0.1943	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1654	0.1662
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0074	0.4483	0.3194
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.0124	0.9951	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.8947	0.8991
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Onchocerca volvulus		0.0124	0.9951	1
Entamoeba histolytica	protein kinase domain containing protein	0.005	0.1943	0.0061
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Schistosoma mansoni	adapter molecule crk	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.4483	0.4505
Echinococcus multilocularis	activin receptor type	0.005	0.1943	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Brugia malayi	Receptor family ligand binding region containing protein	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Brugia malayi	Immunoglobulin I-set domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.4483	0.4505
Echinococcus multilocularis	signal transduction protein lnk realted	0.0074	0.4483	0.3213
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Echinococcus granulosus	hypothetical protein	0.0074	0.4483	0.3194
Schistosoma mansoni	vav2	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Echinococcus multilocularis	tensin	0.0074	0.4483	0.3213
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	signal transduction protein lnk-related	0.0074	0.4483	0.4505
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0074	0.4483	0.3194
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0124	0.9951	0.9939
Loa Loa (eye worm)	TK/DDR protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0124	0.9951	1
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0074	0.4483	0.3194
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.1894	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.005	0.1894	0.1903
Echinococcus multilocularis	SHC transforming protein 3	0.0074	0.4483	0.3213
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Trichomonas vaginalis	AGC family protein kinase	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Plasmodium vivax	tyrosine kinase-like protein, putative	0.005	0.1894	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.005	0.1894	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Echinococcus multilocularis	SH2 motif	0.0074	0.4483	0.3213
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.005	0.1943	1
Brugia malayi	Protein kinase domain containing protein	0.0124	0.9951	1
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0124	0.9951	0.9939
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0074	0.4483	0.4505
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0124	0.9951	1
Trichomonas vaginalis	STE family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0124	0.9951	1
Loa Loa (eye worm)	TK/Met protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.012	0.9518	0.9565
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Giardia lamblia	Kinase	0.005	0.1894	0.5
Brugia malayi	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.1894	0.1903
Brugia malayi	hypothetical protein	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.012	0.9518	0.9565
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Trypanosoma brucei	protein kinase, putative	0.005	0.1943	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0074	0.4532	0.3274
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0074	0.4483	0.3194
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Onchocerca volvulus		0.0074	0.4483	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Echinococcus granulosus	tensin	0.0074	0.4483	0.3194
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0124	0.9951	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Schistosoma mansoni	tensin-related	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0074	0.4483	0.4505
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0124	0.9951	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.005	0.1943	1
Brugia malayi	hypothetical protein	0.005	0.1894	0.1903
Brugia malayi	Tensin	0.0074	0.4483	0.4505
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0124	0.9951	1
Giardia lamblia	Protein 21.1	0.005	0.1894	0.5
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0124	0.9951	0.9939
Loa Loa (eye worm)	TK/ABL protein kinase	0.0124	0.9951	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0124	0.9951	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.005	0.1894	0.1903
Schistosoma mansoni	GTPase activating protein	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0074	0.4483	0.3213
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Giardia lamblia	Kinase, NEK	0.005	0.1894	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0074	0.4483	0.3194
Echinococcus granulosus	SH2 motif	0.0074	0.4483	0.3194
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.9951	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0124	0.9951	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0124	0.9951	0.9939
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Plasmodium vivax	tyrosine kinase-like protein, putative	0.005	0.1894	0.5
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.005	0.1894	0.5
Onchocerca volvulus		0.0124	0.9951	1
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/EPH protein kinase	0.005	0.1894	0.1903
Brugia malayi	RhoGAP domain containing protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Onchocerca volvulus		0.0124	0.9951	1
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.4483	0.4505
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	c src tyrosine kinase	0.0124	0.9951	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0074	0.4483	0.3194
Onchocerca volvulus		0.0074	0.4483	0.3213
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0074	0.4483	0.4505
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0124	0.9951	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0124	0.9951	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.005	0.1943	1
Schistosoma mansoni	protein tyrosine kinase	0.005	0.1894	0.1903
Schistosoma mansoni	hypothetical protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Leishmania major	protein kinase, putative	0.005	0.1943	1
Schistosoma mansoni	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	NCK adaptor protein	0.0074	0.4483	0.3213
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Schistosoma mansoni	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	SRC-1	0.0124	0.9951	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.0124	0.9951	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/EGFR protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/ALK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0124	0.9951	0.9939
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.005	0.1894	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0074	0.4483	0.3194
Schistosoma mansoni	shc transforming protein	0.0074	0.4483	0.4505
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0124	0.9951	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	TK protein kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0124	0.9951	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.1894	0.1903
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0074	0.4483	0.3213
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0124	0.9951	0.9939
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0124	0.9951	0.9939
Onchocerca volvulus		0.0074	0.4483	0.3213
Loa Loa (eye worm)	serine/threonine protein kinase	0.005	0.1894	0.1903
Onchocerca volvulus		0.0074	0.4483	0.3213
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0074	0.4483	0.4505
Echinococcus multilocularis	SH2 motif	0.0074	0.4483	0.3213
Schistosoma mansoni	tensin	0.0074	0.4483	0.4505
Schistosoma mansoni	protein kinase	0.005	0.1894	0.1903
Brugia malayi	integrin-linked kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tensin	0.0074	0.4483	0.4505
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1654	0.1662
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Echinococcus granulosus	NCK adaptor protein	0.0074	0.4483	0.3194
Schistosoma mansoni	tyrosine kinase	0.0124	0.9951	1
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Echinococcus multilocularis		0.0074	0.4483	0.3213
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	activin receptor type	0.005	0.1943	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0074	0.4483	0.4505
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.005	0.1943	0.0061
Loa Loa (eye worm)	TK/FAK protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0124	0.9951	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Echinococcus granulosus	tyrosine kinase	0.0124	0.9951	0.9939
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Loa Loa (eye worm)	hypothetical protein	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Onchocerca volvulus		0.0074	0.4483	0.3213
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0124	0.9951	0.9939
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Entamoeba histolytica	SH2 domain containing protein	0.0074	0.4483	0.3213
Schistosoma mansoni	SH2A	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	N chimaerin	0.0074	0.4483	0.3213
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0124	0.9951	0.9939
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	nck2/grb4	0.0074	0.4483	0.4505
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0074	0.4483	0.3213
Schistosoma mansoni	ephrin receptor	0.005	0.1894	0.1903
Brugia malayi	hypothetical protein	0.0124	0.9951	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0074	0.4483	0.3213
Schistosoma mansoni	protein kinase	0.012	0.9518	0.9565
Brugia malayi	bone morphogenetic protein type 1 receptor	0.005	0.1894	0.1903
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.4483	0.4505
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	SH2 domain containing protein	0.0074	0.4483	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0074	0.4483	0.4505
Brugia malayi	C-terminal src kinase protein 1	0.005	0.1894	0.1903
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1894	0.1903
Schistosoma mansoni	tyrosine protein kinase	0.005	0.1894	0.1903
Echinococcus granulosus	dual specificity mitogen activated protein	0.012	0.9518	0.9406
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0074	0.4483	0.3213
Echinococcus multilocularis	SH2 domain containing protein 7	0.0074	0.4483	0.3213
Brugia malayi	Protein kinase domain containing protein	0.0124	0.9951	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.1894	0.1903
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.4483	0.4505
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0074	0.4483	0.3213
Schistosoma mansoni	suppressor of cytokine signaling	0.0074	0.4483	0.4505
Brugia malayi	Protein kinase domain containing protein	0.005	0.1894	0.1903
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0074	0.4483	0.3194
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.1894	0.1903
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0074	0.4483	0.3213
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0124	0.9951	0.9939
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1894	0.5
Echinococcus granulosus	N chimaerin	0.0074	0.4483	0.3194
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-	0.012	0.9518	0.9565
Trichomonas vaginalis	TKL family protein kinase	0.005	0.1894	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0124	0.9951	0.9939
Schistosoma mansoni	tyrosine kinase	0.005	0.1894	0.1903
Echinococcus granulosus	tyrosine protein kinase Blk	0.0124	0.9951	0.9939

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 12 ug ml-1	Cytotoxicity against human KB cells	ChEMBL.	23647487

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23647487

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2375646

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1760540