Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | phenylalanine decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0186 | 0.0984 | 0.0984 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0186 | 0.0984 | 0.0984 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.1623 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.1747 | 0.1747 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.1623 | 1 | 1 |
Leishmania major | sphingosine 1-phosphate lyase | 0.1623 | 1 | 1 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0186 | 0.0984 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.1623 | 1 | 1 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.1623 | 1 | 1 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.1623 | 1 | 0.5 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1623 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0094 | 0.0407 | 0.0407 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0045 | 0.0045 |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.1747 | 0.1747 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0097 | 0.0427 | 0.0427 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0333 | 0.0333 |
Schistosoma mansoni | transient receptor potential channel | 0.0097 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | TDC-1 protein | 0.0186 | 0.0984 | 0.0984 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0521 | 0.3087 | 0.3087 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0221 | 0.0221 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.1747 | 0.1747 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0094 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0201 | 0.0201 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0186 | 0.0984 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0221 | 0.0221 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0097 | 0.0427 | 0.0427 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0221 | 0.0221 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0186 | 0.0984 | 0.5 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0186 | 0.0984 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0186 | 0.0984 | 0.0984 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0045 | 0.0045 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.1747 | 0.1747 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0186 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0045 | 0.0045 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0186 | 0.0984 | 0.0984 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0186 | 0.0984 | 0.0984 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.1623 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0025 | 0.0025 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0097 | 0.0427 | 0.0427 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0045 | 0.0045 |
Brugia malayi | glutamate decarboxylase putative | 0.0186 | 0.0984 | 0.0984 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0186 | 0.0984 | 0.0984 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1623 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.5 uM | Inhibition of BACE1-mediated soluble APPbeta release in human SH-SY5Y cells after 16 hrs | ChEMBL. | 23126626 |
IC50 (binding) | = 32 uM | Inhibition of human BACE1 (1-460) using CEVNLDAEFK as substrate preincubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRET assay | ChEMBL. | 23126626 |
Papp (ADMET) | = 23 ucm/s | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM after 30 to 60 mins at pH 7.4 by LC/MS analysis | ChEMBL. | 23126626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.