Detailed information for compound 1761972

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.44 | Formula: C29H28BrNO5
  • H donors: 0 H acceptors: 2 LogP: 5.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1Br)[C@H]1CC2(ON1c1ccccc1)C(=O)O[C@H]1[C@H]2CC[C@@]2(C1=C(C)C(=O)C=C2)C
  • InChi: 1S/C29H28BrNO5/c1-17-23(32)12-14-28(2)13-11-20-26(25(17)28)35-27(33)29(20)16-22(18-9-10-24(34-3)21(30)15-18)31(36-29)19-7-5-4-6-8-19/h4-10,12,14-15,20,22,26H,11,13,16H2,1-3H3/t20-,22-,26+,28+,29?/m1/s1
  • InChiKey: WUQVYYITCVOYDQ-XXFKYZDNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NCK adaptor protein 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni shc transforming protein 0.1361 0.5977 0.5977
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1361 0.5977 0.5953
Brugia malayi Raf kinase 0.091 0.3986 0.3629
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0494 0.2148 0.2148
Trichomonas vaginalis CAMK family protein kinase 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.2271 1 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2271 0.9999 0.9999
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2271 0.9999 0.9999
Echinococcus granulosus tyrosine protein kinase csk 0.091 0.3986 0.3986
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1361 0.5977 0.5953
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine kinase 0.091 0.3986 0.3986
Echinococcus multilocularis raf serine:threonine protein kinase 0.091 0.3986 0.3986
Onchocerca volvulus 0.2271 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Entamoeba histolytica ankyrin repeat protein 0.091 0.3986 0.3827
Loa Loa (eye worm) RGC/RGC protein kinase 0.091 0.3986 0.3949
Echinococcus multilocularis SH2 motif 0.1361 0.5977 0.5977
Onchocerca volvulus 0.2271 0.9999 1
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.091 0.3986 0.3986
Echinococcus granulosus epidermal growth factor receptor 0.091 0.3986 0.3986
Trypanosoma brucei protein kinase, putative 0.091 0.3986 1
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) TK/RYK protein kinase 0.091 0.3986 0.3949
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.091 0.3986 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Echinococcus multilocularis activated cdc42 kinase 1 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine protein kinase Src64B 0.2271 0.9999 0.9999
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus signal transduction protein lnk realted 0.1361 0.5977 0.5977
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2271 0.9999 0.9999
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Echinococcus multilocularis heat shock protein 70 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.2271 0.9999 1
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0418 0.1811 0.1811
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni suppressor of cytokine signaling 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) SH2 domain-containing protein 0.1361 0.5977 0.5953
Loa Loa (eye worm) hypothetical protein 0.2271 0.9999 1
Brugia malayi SH2 domain containing protein 0.2271 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0115 0.0471 0.0471
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine protein kinase pr2 0.091 0.3986 0.3986
Schistosoma mansoni signal transduction protein lnk-related 0.1361 0.5977 0.5977
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Echinococcus granulosus activated cdc42 kinase 1 0.091 0.3986 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Brugia malayi Protein kinase domain containing protein 0.2271 0.9999 1
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/EPH protein kinase 0.091 0.3986 0.3949
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus granulosus tyrosine protein kinase HCK 0.091 0.3986 0.3986
Brugia malayi Variant SH3 domain containing protein 0.1361 0.5977 0.5739
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1361 0.5977 0.5953
Schistosoma mansoni SH2A 0.1361 0.5977 0.5977
Echinococcus granulosus dual specificity testis-specific protein kinase 0.091 0.3986 0.3986
Onchocerca volvulus 0.2271 0.9999 1
Echinococcus multilocularis tyrosine protein kinase csk 0.091 0.3986 0.3986
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica ankyrin repeat protein 0.091 0.3986 0.3827
Toxoplasma gondii STE kinase 0.091 0.3986 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1361 0.5977 0.5953
Echinococcus multilocularis tankyrase 0.0136 0.0564 0.0564
Brugia malayi Sex muscle abnormal protein 5 0.1361 0.5977 0.5739
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Brugia malayi hypothetical protein 0.091 0.3986 0.3629
Echinococcus granulosus epidermal growth factor receptor 0.091 0.3986 0.3986
Echinococcus multilocularis epidermal growth factor receptor 0.091 0.3986 0.3986
Entamoeba histolytica tyrosin kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni tensin-related 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK/KIN6 protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Echinococcus granulosus tensin 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1361 0.5977 0.5977
Leishmania major hypothetical protein, conserved 0.091 0.3986 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/Met protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0352 0.1517 0.1517
Echinococcus multilocularis SH2 domain containing protein 7 0.1361 0.5977 0.5977
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni serine/threonine protein kinase 0.091 0.3986 0.3986
Trichomonas vaginalis serine-threonine protein kinase, putative 0.091 0.3986 1
Loa Loa (eye worm) SH2 domain-containing protein 0.1361 0.5977 0.5953
Giardia lamblia Kinase, NEK 0.091 0.3986 1
Brugia malayi Protein kinase domain containing protein 0.2271 0.9999 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus multilocularis retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.2271 0.9999 0.9999
Brugia malayi hypothetical protein 0.1361 0.5977 0.5739
Onchocerca volvulus Tankyrase homolog 0.0128 0.0528 0.0469
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus natriuretic peptide receptor 1 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine kinase 0.091 0.3986 0.3986
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.091 0.3986 0.3986
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.091 0.3986 0.3986
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2271 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Schistosoma mansoni hypothetical protein 0.1361 0.5977 0.5977
Schistosoma mansoni src-type protein tyrosine kinase-related 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.091 0.3986 0.3629
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Plasmodium vivax tyrosine kinase-like protein, putative 0.0917 0.4017 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.091 0.3986 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.091 0.3986 0.3986
Loa Loa (eye worm) SRC-1 0.2271 0.9999 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1361 0.5977 0.5977
Brugia malayi WGR domain containing protein 0.0494 0.2148 0.1682
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2271 0.9999 0.9999
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0181 0.0765 0.0765
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) TK/ROR protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.091 0.3986 0.3629
Plasmodium falciparum tyrosine kinase-like protein 0.0917 0.4017 1
Echinococcus multilocularis epidermal growth factor receptor 0.091 0.3986 0.3986
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Onchocerca volvulus 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus c src tyrosine kinase 0.2271 0.9999 0.9999
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1361 0.5977 0.5953
Echinococcus granulosus tyrosine protein kinase Srms 0.2271 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Onchocerca volvulus 0.2271 0.9999 1
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Echinococcus granulosus poly adp ribose polymerase 2 0.0418 0.1811 0.1811
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.091 0.3986 0.3629
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2271 0.9999 0.9999
Echinococcus multilocularis kinase suppressor of Ras 1 0.091 0.3986 0.3986
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1361 0.5977 0.5977
Onchocerca volvulus Tyrosine kinase homolog 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Onchocerca volvulus 0.091 0.3986 0.3949
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni vav2 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1361 0.5977 0.5977
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Brugia malayi hypothetical protein 0.2271 0.9999 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Echinococcus multilocularis signal transduction protein lnk realted 0.1361 0.5977 0.5977
Brugia malayi Probable tyrosine-protein kinase kin-31 0.091 0.3986 0.3629
Brugia malayi Furin-like cysteine rich region family protein 0.091 0.3986 0.3629
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trichomonas vaginalis protein kinase atn1, putative 0.091 0.3986 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.091 0.3986 0.3986
Echinococcus granulosus hypothetical protein 0.1361 0.5977 0.5977
Echinococcus multilocularis tyrosine kinase 0.2271 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) serine/threonine protein kinase 0.091 0.3986 0.3949
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Onchocerca volvulus 0.1361 0.5977 0.5953
Loa Loa (eye worm) TK/EGFR protein kinase 0.091 0.3986 0.3949
Schistosoma mansoni ephrin receptor 0.091 0.3986 0.3986
Toxoplasma gondii protein kinase domain-containing protein 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.091 0.3986 0.3986
Leishmania major protein kinase, putative 0.091 0.3986 1
Onchocerca volvulus 0.1361 0.5977 0.5953
Echinococcus granulosus SHC transforming protein 3 0.1361 0.5977 0.5977
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Brugia malayi C-terminal src kinase protein 1 0.091 0.3986 0.3629
Echinococcus granulosus WGR domain containing protein 0.023 0.0979 0.0979
Echinococcus multilocularis tensin 0.1361 0.5977 0.5977
Echinococcus granulosus activated cdc42 kinase 1 0.091 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Loa Loa (eye worm) STAT protein 0.1361 0.5977 0.5953
Entamoeba histolytica tyrosin kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni adapter molecule crk 0.1361 0.5977 0.5977
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/ALK protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Echinococcus granulosus protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2271 0.9999 1
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Brugia malayi Immunoglobulin I-set domain containing protein 0.091 0.3986 0.3629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1361 0.5977 0.5739
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) tnks protein 0.0129 0.0533 0.0475
Onchocerca volvulus 0.2271 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase csk 0.091 0.3986 0.3986
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Echinococcus granulosus tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1361 0.5977 0.5953
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.091 0.3986 0.3629
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni suppressor of cytokine signaling 0.1361 0.5977 0.5977
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Loa Loa (eye worm) TK/ABL protein kinase 0.2271 0.9999 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Schistosoma mansoni tensin-related 0.1361 0.5977 0.5977
Loa Loa (eye worm) SH2 domain-containing protein 0.1361 0.5977 0.5953
Entamoeba histolytica SH2 domain containing protein 0.1361 0.5977 0.5871
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Brugia malayi Protein kinase domain containing protein 0.2271 0.9999 1
Echinococcus multilocularis tyrosine protein kinase shark 0.2271 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Brugia malayi cytokine inducible SH2-containing protein 5 0.1361 0.5977 0.5739
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi ephrin receptor 1 precursor 0.091 0.3986 0.3629
Echinococcus granulosus tyrosine protein kinase Blk 0.2271 0.9999 0.9999
Echinococcus multilocularis FL cytokine receptor 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Schistosoma mansoni GTPase activating protein 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni growth factor receptor-bound protein 0.1361 0.5977 0.5977
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Brugia malayi SRC-1 0.2271 0.9999 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.091 0.3986 1
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis fibroblast growth factor receptor 4 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Echinococcus granulosus tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi hypothetical protein 0.091 0.3986 0.3629
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi integrin-linked kinase 0.091 0.3986 0.3629
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.091 0.3986 0.3986
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Loa Loa (eye worm) TK protein kinase 0.2271 0.9999 1
Echinococcus multilocularis N chimaerin 0.1361 0.5977 0.5977
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis SH2 motif 0.1361 0.5977 0.5977
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.091 0.3986 0.3949
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0494 0.2148 0.2148
Brugia malayi Immunoglobulin I-set domain containing protein 0.091 0.3986 0.3629
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1361 0.5977 0.5871
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Schistosoma mansoni hypothetical protein 0.091 0.3986 0.3986
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis protein kinase 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine protein kinase Lyn 0.2271 0.9999 0.9999
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1361 0.5977 0.5977
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Echinococcus granulosus N chimaerin 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0494 0.2148 0.1941
Onchocerca volvulus 0.1361 0.5977 0.5953
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Echinococcus granulosus ephrin type A receptor 4 A 0.091 0.3986 0.3986
Echinococcus multilocularis protein KINase family member (kin 25) 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus granulosus protein tyrosine kinase 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Schistosoma mansoni tyrosine protein kinase 0.091 0.3986 0.3986
Echinococcus multilocularis protein kinase 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.091 0.3986 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Loa Loa (eye worm) TK/INSR protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase csk 0.091 0.3986 0.3986
Entamoeba histolytica hypothetical protein, conserved 0.091 0.3986 0.3827
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/CSK protein kinase 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Entamoeba histolytica receptor protein kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.091 0.3986 0.3986
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi Tyrosine-protein kinase PR2 0.091 0.3986 0.3629
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.091 0.3986 0.3986
Trichomonas vaginalis protein tyrosine kinase, putative 0.091 0.3986 1
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Echinococcus granulosus poly (ADP ribose) polymerase 0.0115 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Brugia malayi RhoGAP domain containing protein 0.1361 0.5977 0.5739
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2271 0.9999 0.9999
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Trypanosoma brucei poly(adp-ribose) polymerase 0.0418 0.1811 0.4458
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1361 0.5977 0.5977
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.091 0.3986 0.3827
Echinococcus multilocularis SHC transforming protein 3 0.1361 0.5977 0.5977
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1361 0.5977 0.5977
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine kinase 0.2271 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni ephrin receptor 0.091 0.3986 0.3986
Echinococcus granulosus poly ADP ribose polymerase 1 0.0494 0.2148 0.2148
Schistosoma mansoni tensin 0.1361 0.5977 0.5977
Schistosoma mansoni tyrosine kinase 0.2271 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2271 0.9999 0.9999
Echinococcus multilocularis receptor type guanylyl cyclase 0.091 0.3986 0.3986
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Onchocerca volvulus 0.091 0.3986 0.3949
Echinococcus granulosus tyrosine protein kinase Btk29A 0.091 0.3986 0.3986
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0418 0.1811 0.1811
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.091 0.3986 0.3986
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus tyrosine protein kinase 0.091 0.3986 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1361 0.5977 0.5977
Schistosoma mansoni tensin 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.091 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni tankyrase 0.0136 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Brugia malayi tRNA modification GTPase TrmE family protein 0.1361 0.5977 0.5739
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1361 0.5977 0.5977
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.091 0.3986 1
Schistosoma mansoni hypothetical protein 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Schistosoma mansoni tyrosine kinase 0.2271 0.9999 0.9999
Schistosoma mansoni tyrosine-protein kinase fps85d 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1361 0.5977 0.5977
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0418 0.1811 0.4458
Echinococcus multilocularis growth factor receptor bound protein 2 0.1361 0.5977 0.5977
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus granulosus raf serine:threonine protein kinase 0.091 0.3986 0.3986
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.091 0.3986 1
Echinococcus granulosus SH2 motif 0.1361 0.5977 0.5977
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus multilocularis SH2 motif 0.1361 0.5977 0.5977
Echinococcus multilocularis tensin 0.1361 0.5977 0.5977
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Brugia malayi Variant SH3 domain containing protein 0.1361 0.5977 0.5739
Brugia malayi Variant SH3 domain containing protein 0.1361 0.5977 0.5739
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus insulin growth factor 1 receptor beta 0.091 0.3986 0.3986
Plasmodium falciparum protein kinase, putative 0.0917 0.4017 1
Trichomonas vaginalis TK family protein kinase 0.091 0.3986 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica tyrosin kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni tensin 0.1361 0.5977 0.5977
Echinococcus granulosus SH2 motif 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK/ACK protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase Blk 0.2271 0.9999 0.9999
Schistosoma mansoni serine/threonine protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Onchocerca volvulus 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis insulin receptor 0.091 0.3986 0.3986
Loa Loa (eye worm) TK/FER protein kinase 0.091 0.3986 0.3949
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2271 0.9999 0.9999
Echinococcus granulosus integrin linked protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Echinococcus granulosus growth factor receptor bound protein 2 0.1361 0.5977 0.5977
Brugia malayi Probable tyrosine-protein kinase kin-31 0.091 0.3986 0.3629
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1361 0.5977 0.5977
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2271 0.9999 0.9999
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.091 0.3986 0.3986
Loa Loa (eye worm) protein kinase domain-containing protein 0.091 0.3986 0.3949
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Loa Loa (eye worm) TK/DDR protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica receptor protein kinase, putative 0.091 0.3986 0.3827
Echinococcus granulosus kinase suppressor of Ras 1 0.091 0.3986 0.3986
Brugia malayi Variant SH3 domain containing protein 0.1361 0.5977 0.5739
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.091 0.3986 0.3986
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.091 0.3986 0.3986
Echinococcus granulosus fibroblast growth factor receptor 4 0.091 0.3986 0.3986
Echinococcus multilocularis tyrosine protein kinase Srms 0.2271 0.9999 0.9999
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.091 0.3986 0.3629
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Echinococcus granulosus poly (ADP ribose) polymerase 0.0115 0.0471 0.0471
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus insulin receptor 0.091 0.3986 0.3986
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0303 0.1303 0.1249
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1361 0.5977 0.5953
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Brugia malayi Receptor family ligand binding region containing protein 0.091 0.3986 0.3629
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Trichomonas vaginalis STE family protein kinase 0.091 0.3986 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) RGC/RGC protein kinase 0.091 0.3986 0.3949
Schistosoma mansoni protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica hypothetical protein 0.0115 0.0471 0.022
Schistosoma mansoni nck2/grb4 0.1361 0.5977 0.5977
Schistosoma mansoni tyrosine kinase 0.2271 0.9999 0.9999
Echinococcus granulosus retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Echinococcus granulosus tyrosine kinase 0.2271 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2271 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1361 0.5977 0.5977
Echinococcus multilocularis activin receptor type 0.091 0.3986 0.3986
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Onchocerca volvulus 0.2271 0.9999 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus NCK adaptor protein 0.1361 0.5977 0.5977
Schistosoma mansoni serine/threonine protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus granulosus activin receptor type 0.091 0.3986 0.3986
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1361 0.5977 0.5977
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Trypanosoma brucei Pseudokinase, putative 0.091 0.3986 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.2271 0.9999 0.9999
Echinococcus multilocularis c src tyrosine kinase 0.2271 0.9999 0.9999
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Echinococcus granulosus tankyrase 0.0136 0.0564 0.0564
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.091 0.3986 0.3949
Treponema pallidum bacterioferrin (TpF1) 0.0008 0 0.5
Echinococcus granulosus expressed conserved protein 0.1361 0.5977 0.5977
Echinococcus granulosus SH2 domain containing adapter protein F 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.091 0.3986 0.3949
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) hypothetical protein 0.0306 0.1316 0.1263
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Onchocerca volvulus 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase, putative 0.1361 0.5977 0.5871
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1361 0.5977 0.5977
Echinococcus granulosus SH2 domain containing protein 7 0.1361 0.5977 0.5977
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis protein tyrosine kinase 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Loa Loa (eye worm) hypothetical protein 0.0418 0.1811 0.176
Trypanosoma cruzi protein kinase, putative 0.091 0.3986 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Brugia malayi Tensin 0.1361 0.5977 0.5739
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.091 0.3986 0.3986
Echinococcus granulosus poly (ADP ribose) polymerase 0.023 0.0979 0.0979
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica cysteine surface protein, putative 0.091 0.3986 0.3827
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.091 0.3986 0.3986
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.091 0.3986 0.3949
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Onchocerca volvulus 0.091 0.3986 0.3949
Brugia malayi Protein kinase domain containing protein 0.2271 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trypanosoma cruzi protein kinase, putative 0.091 0.3986 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.091 0.3986 0.3949
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2271 0.9999 0.9999
Brugia malayi WGR domain containing protein 0.0418 0.1811 0.1325
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni protein tyrosine kinase 0.091 0.3986 0.3986
Giardia lamblia Protein 21.1 0.091 0.3986 0.0001
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0 0.5
Brugia malayi SH2 domain containing protein 0.2271 0.9999 1
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Onchocerca volvulus 0.1361 0.5977 0.5953
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Onchocerca volvulus 0.091 0.3986 0.3949
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1361 0.5977 0.5977
Echinococcus granulosus tyrosine protein kinase Src42A 0.1361 0.5977 0.5977
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Echinococcus multilocularis retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus tyrosine protein kinase csk 0.091 0.3986 0.3986
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Echinococcus multilocularis tyrosine protein kinase pr2 0.091 0.3986 0.3986
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Onchocerca volvulus 0.1361 0.5977 0.5953
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Brugia malayi Tyrosine-protein kinase abl-1 0.2271 0.9999 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Onchocerca volvulus 0.1361 0.5977 0.5953
Brugia malayi Guanylyl cyclase protein 23 0.091 0.3986 0.3629
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2271 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis tyrosine protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Leishmania major protein kinase, putative 0.091 0.3986 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0257 0.0645
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Brugia malayi Protein kinase domain containing protein 0.091 0.3986 0.3629
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Entamoeba histolytica protein kinase domain containing protein 0.091 0.3986 0.3827
Brugia malayi STAT protein, DNA binding domain containing protein 0.1361 0.5977 0.5739
Echinococcus multilocularis integrin linked protein kinase 0.091 0.3986 0.3986
Echinococcus multilocularis dual specificity testis specific protein kinase 0.091 0.3986 0.3986
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.091 0.3986 0.3827
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Echinococcus granulosus tyrosine protein kinase Src42A 0.2271 0.9999 0.9999
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni serine/threonine protein kinase 0.091 0.3986 0.3986
Echinococcus multilocularis 0.1361 0.5977 0.5977
Onchocerca volvulus 0.091 0.3986 0.3949
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1361 0.5977 0.5953
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.091 0.3986 0.3986
Schistosoma mansoni growth factor receptor-bound protein 0.1361 0.5977 0.5977
Onchocerca volvulus 0.091 0.3986 0.3949
Entamoeba histolytica serine/threonine kinase, putative 0.091 0.3986 0.3827
Trichomonas vaginalis conserved hypothetical protein 0.091 0.3986 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1361 0.5977 0.5977
Loa Loa (eye worm) hypothetical protein 0.091 0.3986 0.3949
Echinococcus multilocularis tyrosine protein kinase Abl 0.2271 0.9999 0.9999
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0418 0.1811 0.4458
Echinococcus granulosus tyrosine protein kinase csk 0.091 0.3986 0.3986
Echinococcus multilocularis ephrin type A receptor 4 A 0.091 0.3986 0.3986
Echinococcus granulosus suppressor of cytokine signaling 6 0.1361 0.5977 0.5977
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis transfer RNA-Thr 0.091 0.3986 0.3986
Loa Loa (eye worm) TK/FER protein kinase 0.2271 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.1361 0.5977 0.5977
Echinococcus granulosus receptor type guanylyl cyclase 0.091 0.3986 0.3986
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Loa Loa (eye worm) TK protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Brugia malayi SH2 domain containing protein 0.1361 0.5977 0.5739
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni tyrosine kinase 0.2271 0.9999 0.9999
Entamoeba histolytica tyrosin kinase, putative 0.091 0.3986 0.3827
Schistosoma mansoni serine/threonine RGC 0.091 0.3986 0.3986
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2271 0.9999 0.9999
Trichomonas vaginalis AGC family protein kinase 0.091 0.3986 1
Loa Loa (eye worm) TK/FAK protein kinase 0.091 0.3986 0.3949
Loa Loa (eye worm) hypothetical protein 0.1361 0.5977 0.5953
Schistosoma mansoni tyrosine-protein kinase fps85d 0.091 0.3986 0.3986
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.091 0.3986 0.3986
Entamoeba histolytica protein kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica tyrosine kinase, putative 0.091 0.3986 0.3827
Entamoeba histolytica hypothetical protein 0.091 0.3986 0.3827
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.091 0.3986 0.3986
Toxoplasma gondii protein kinase 0.091 0.3986 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2271 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.0061 0.0235 0.0174
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.091 0.3986 0.3949
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.091 0.3986 0.3986
Brugia malayi protein-tyrosine kinase 0.2271 0.9999 1
Schistosoma mansoni tyrosine kinase 0.091 0.3986 0.3986
Trichomonas vaginalis TKL family protein kinase 0.091 0.3986 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8.5 uM Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay ChEMBL. 23501113
IC50 (functional) = 100 uM Antiproliferative activity against human Hep2 cells after 48 hrs by sulforhodamine B assay ChEMBL. 23501113

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23501113

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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