Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0469 | 0.0442 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0012 | 0.0012 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0035 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0035 | 0.0008 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.074 | 0.0715 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.06 | 0.0589 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0624 | 1 | 1 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0009 | 0.0027 | 0.0016 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0624 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0972 | 0.0947 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0624 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0624 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0027 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0972 | 0.0961 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0469 | 0.0469 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0972 | 0.0947 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0154 | 0.0127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Onchocerca volvulus | 0.0047 | 0.0636 | 0.2036 | |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Echinococcus multilocularis | sodium channel protein | 0.0074 | 0.1086 | 0.1075 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0154 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.074 | 0.0715 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0154 | 0.0127 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.06 | 0.0575 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.074 | 0.0715 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0008 | 0.0012 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0972 | 0.0961 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0047 | 0.0636 | 0.0636 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0012 | 0.0012 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0035 | 0.0035 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0469 | 0.0442 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0154 | 0.0142 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.06 | 0.0589 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.06 | 0.0589 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0972 | 0.0947 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0154 | 0.0142 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0035 | 0.0008 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0154 | 0.0142 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.074 | 0.0715 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus granulosus | tumor protein p63 | 0.0318 | 0.5033 | 0.5028 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0636 | 0.0611 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0035 | 0.0035 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0154 | 0.0127 |
Echinococcus multilocularis | tumor protein p63 | 0.0318 | 0.5033 | 0.5028 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0027 | 0.0016 |
Brugia malayi | N-terminal motif family protein | 0.0192 | 0.2987 | 0.2968 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0624 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2987 | 0.2968 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0012 | 0.0012 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0972 | 0.0947 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0027 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | sodium channel protein | 0.0074 | 0.1086 | 0.1075 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0154 | 0.0142 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.06 | 0.0575 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0035 | 0.0008 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0972 | 0.0947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.06 | 0.0589 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 0.2987 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0154 | 0.0142 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0035 | 0.0008 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0154 | 0.0142 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0008 | 0.0012 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0074 | 0.1086 | 0.1075 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0035 | 0.0035 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0972 | 0.0947 |
Echinococcus granulosus | voltage gated potassium channel | 0.0009 | 0.0027 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0074 | 0.1086 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0008 | 0.0012 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0035 | 0.0008 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | >= 300 uM | Inhibition of 6xHis-tagged Src catalytic domain (unknown origin) expressed in Escherichia coli using AEEEIYGEFEAKKKK as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by fluorescence intensity assay | ChEMBL. | 23602444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.