Detailed information for compound 1768441

Basic information

Technical information
  • TDR Targets ID: 1768441
  • Name: (Z,2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]ami no]-4-hydroxy-4-oxobutanoyl]amino]-5-phosphon opent-3-enoic acid
  • MW: 381.276 | Formula: C12H20N3O9P
  • H donors: 7 H acceptors: 9 LogP: -6.09 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C[C@@H](C(=O)N[C@H](C(=O)O)/C=C\CP(=O)(O)O)NC(=O)[C@@H](N)C
  • InChi: 1S/C12H20N3O9P/c1-6(13)10(18)15-8(5-9(16)17)11(19)14-7(12(20)21)3-2-4-25(22,23)24/h2-3,6-8H,4-5,13H2,1H3,(H,14,19)(H,15,18)(H,16,17)(H,20,21)(H2,22,23,24)/b3-2-/t6-,7-,8-/m0/s1
  • InChiKey: BMFVTRZNBFRUMH-KPFVRPAQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z,2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-5-phosphono-pent-3-enoic acid
  • (Z,2S)-2-[[(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-4-hydroxy-1,4-dioxobutyl]amino]-5-phosphonopent-3-enoic acid
  • (Z,2S)-2-[[(2S)-2-(alanylamino)-4-hydroxy-4-keto-butanoyl]amino]-5-phosphono-pent-3-enoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0346 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0031 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0031 0.0079
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.054 0.7801
Schistosoma mansoni elf1 0.001 0.0036 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0673 0.1693
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0031 0.007
Schistosoma mansoni hypothetical protein 0.001 0.0036 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Schistosoma mansoni gabp alpha 0.0071 0.0728 0.183
Brugia malayi ecdysteroid receptor 0.001 0.0031 0.007
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0358 0.3977 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.007
Brugia malayi glutathione reductase 0.0038 0.0346 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0344 0.9924
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0344 0.4567
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0247 0.0611
Plasmodium falciparum glutathione reductase 0.0038 0.0346 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0614 0.1545
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0728 0.1822
Schistosoma mansoni hypothetical protein 0.0167 0.1812 0.4557
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.007
Brugia malayi Metabotropic glutamate receptor precursor. 0.0046 0.0444 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0031 0.007
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0344 0.1079
Loa Loa (eye worm) glutamate receptor 0.0046 0.0444 0.1108
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0346 0.0861
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0081
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0004 0.001
Echinococcus granulosus protein C ets 2 0.001 0.0036 0.009
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0358 0.3977 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0525 0.1311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0031 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Onchocerca volvulus 0.0038 0.0344 0.2096
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0079
Brugia malayi Fli-1 protein 0.0217 0.2376 0.597
Onchocerca volvulus 0.0151 0.1626 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0031 0.0079
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0067 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0012 0.0053 0.0124
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0036 0.0036
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0053 0.0516 0.1298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0081
Brugia malayi beta-lactamase family protein 0.0038 0.0344 0.0856
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1002 0.3642
Plasmodium vivax glutathione reductase, putative 0.0038 0.0346 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0344 0.1079
Echinococcus granulosus metabotropic glutamate receptor 5 0.0057 0.0566 0.1422
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0036 0.009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0151 0.1626 0.4082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0344 0.1079
Brugia malayi Thioredoxin reductase 0.0038 0.0346 0.0861
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0333 0.0828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0268
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0124
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0344 0.4567
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0036 0.0321 0.0806
Echinococcus granulosus metabotropic glutamate receptor 2 0.0039 0.0359 0.0902
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0673 1
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0036 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0344 0.0864
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0344 0.1079
Schistosoma mansoni metabotropic glutamate receptor 0.0023 0.0175 0.0439
Brugia malayi nuclear receptor NHR-88 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0031 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Brugia malayi nuclear hormone receptor 0.001 0.0031 0.007
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0067 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0893 0.3219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0475 0.0475
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0027 0.0059
Leishmania major trypanothione reductase 0.0038 0.0346 0.4602
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0067 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1002 0.3642
Loa Loa (eye worm) fli-1 protein 0.0217 0.2376 0.597
Loa Loa (eye worm) beta-lactamase 0.0038 0.0344 0.0856
Onchocerca volvulus 0.0038 0.0344 0.2096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0344 0.1079
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.005
Echinococcus multilocularis protein C ets 2 0.001 0.0036 0.0036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0673 0.2362
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0027 0.0059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.007
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1002 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0673 0.0673
Brugia malayi Latrophilin receptor protein 2 0.0017 0.011 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.007
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0358 0.3977 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0057 0.0566 0.0566
Brugia malayi transcription factor E74 isoform 0.001 0.0036 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0344 0.9924
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0333 0.0828
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0566 0.1414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Mycobacterium ulcerans lipase LipD 0.0038 0.0344 0.4567
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0037 0.0333 0.0837
Mycobacterium tuberculosis Probable reductase 0.0086 0.0893 0.3219
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0346 0.1087
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0321 0.0806
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0031 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0031 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0031 0.0079
Echinococcus granulosus cpg binding protein 0.0031 0.0265 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.007
Toxoplasma gondii thioredoxin reductase 0.0038 0.0346 0.4602
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0031 0.007
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0036 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0036 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0344 0.1079
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0036 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0344 0.0864
Schistosoma mansoni ets-related 0.0217 0.2376 0.5974
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0673 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Schistosoma mansoni nuclear hormone receptor 0.001 0.0031 0.0079
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0728 0.0728
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Brugia malayi Ets-domain containing protein 0.0071 0.0728 0.1822
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Echinococcus granulosus GPCR family 2 0.0017 0.011 0.0277
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0031 0.0079
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0036 0.0036
Toxoplasma gondii ABC1 family protein 0.0038 0.0344 0.4567
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0012 0.0053 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0358 0.3977 0.3977
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0031 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0167 0.1812 0.4557
Brugia malayi hypothetical protein 0.0036 0.0321 0.0797
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.011 0.0277
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0475 0.1185
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0667
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0475 0.1193
Leishmania major hypothetical protein, conserved 0.0038 0.0344 0.4567
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0031 0.0031
Brugia malayi beta-lactamase 0.0038 0.0344 0.0856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.011 0.011
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.011 0.0277
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0067 0.5
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0728 0.183
Trypanosoma brucei trypanothione reductase 0.0038 0.0346 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0346 0.0861
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1
Echinococcus multilocularis geminin 0.0167 0.1812 0.1812
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0525 0.1311
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0344 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.007
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0893 0.3219
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0352 0.0352
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Brugia malayi beta-lactamase family protein 0.0038 0.0344 0.0856
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.0346 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0344 0.9924
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0008 0.0004 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0344 1
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0673 0.1693
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0067 0.0158
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0031 0.0079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0344 0.0864
Brugia malayi CXXC zinc finger family protein 0.0029 0.0247 0.0611
Loa Loa (eye worm) hypothetical protein 0.0054 0.0525 0.1311
Mycobacterium ulcerans beta-lactamase 0.0038 0.0344 0.4567
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0036 0.009
Brugia malayi steroid hormone receptor 0.001 0.0031 0.007
Echinococcus multilocularis ets variant gene 4 0.001 0.0036 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.011 0.0268
Schistosoma mansoni ets 0.001 0.0036 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0031 0.0079
Mycobacterium ulcerans hypothetical protein 0.0038 0.0344 0.4567
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0031 0.0079
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0346 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0031 0.007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Schistosoma mansoni coup transcription factor 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Schistosoma mansoni ets-related 0.001 0.0036 0.009
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0031 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0079
Trichomonas vaginalis esterase, putative 0.0038 0.0344 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0167
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0352 0.0884
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0036 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0031 0.017
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Brugia malayi hypothetical protein 0.0151 0.1626 0.4082
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0036 0.009
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0036 0.0081
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0893 0.3219
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0893 0.8348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.007
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0042 0.0395 0.0984
Schistosoma mansoni cpg binding protein 0.0029 0.0247 0.062
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Brugia malayi Ets-domain containing protein 0.0071 0.0728 0.1822
Echinococcus multilocularis cpg binding protein 0.0031 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0061 0.061 0.1527
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0031 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Schistosoma mansoni hypothetical protein 0.001 0.0036 0.009
Brugia malayi metabotropic glutamate receptor type 2 0.0023 0.0175 0.043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0525 0.1311
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0036 0.0081
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0036 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.007
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0039 0.0359 0.0359
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0031 0.0079
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Onchocerca volvulus 0.0029 0.0247 0.1497
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0031 0.017
Echinococcus multilocularis GPCR, family 2 0.0017 0.011 0.011
Echinococcus granulosus geminin 0.0167 0.1812 0.4557
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Onchocerca volvulus 0.0038 0.0344 0.2096
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0031 0.0031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2635 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0358 0.3977 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0673 0.1693
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0344 0.0856
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0475 0.1185
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0036 0.0081
Loa Loa (eye worm) glutamate receptor 0.0018 0.0125 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0475 0.1193
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0344 0.9924
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1002 0.3642
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0344 0.1079
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0036 0.009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0344 0.0856
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0893 0.3219
Brugia malayi Ets-domain containing protein 0.001 0.0036 0.0081
Schistosoma mansoni metabotropic glutamate receptor 0.0039 0.0359 0.0902
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0321 0.0806
Treponema pallidum NADH oxidase 0.0013 0.0067 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0893 0.3219
Onchocerca volvulus 0.001 0.0031 0.017
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0036 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.011 0.0268
Brugia malayi Receptor family ligand binding region containing protein 0.0012 0.0053 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli 2 to 10 ug/L after 24 hrs by microdilution method ChEMBL. 23891162
Activity (functional) Antibacterial activity against Escherichia coli 2 to 10 ug/L after 24 hrs by Stephenson-Wetham medium disc diffusion method in absence of amino acids ChEMBL. 23891162
Activity (functional) Antibacterial activity against Escherichia coli 2 to 10 ug/L after 24 hrs by Stephenson-Wetham medium disc diffusion method ChEMBL. 23891162

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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