Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0124 | 0.0608 | 0.0608 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0421 | 0.2788 | 0.2788 |
Brugia malayi | Choline O-acetyltransferase | 0.0124 | 0.0608 | 0.1031 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0124 | 0.0608 | 0.0977 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.031 | 0.1974 | 0.3401 |
Schistosoma mansoni | P2X receptor subunit | 0.1403 | 1 | 1 |
Onchocerca volvulus | 0.0124 | 0.0608 | 0.5 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0124 | 0.0608 | 0.0608 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0421 | 0.2788 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0816 | 0.569 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0124 | 0.0608 | 0.1031 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.031 | 0.1974 | 0.1974 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.031 | 0.1974 | 0.3441 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0124 | 0.0608 | 0.5 | |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1403 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0141 | 0.0147 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0124 | 0.0608 | 0.0977 |
Onchocerca volvulus | 0.0124 | 0.0608 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0124 | 0.0608 | 0.0608 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1403 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0141 | 0.0141 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.031 | 0.1974 | 0.6264 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0058 | 0.006 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.031 | 0.1974 | 0.6264 |
Onchocerca volvulus | 0.0124 | 0.0608 | 0.5 | |
Schistosoma mansoni | P2X receptor subunit | 0.1403 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0124 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 0.569 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.031 | 0.1974 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.031 | 0.1974 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0608 | 0.0977 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0421 | 0.2788 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1403 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0421 | 0.2788 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0421 | 0.2788 | 0.2788 |
Brugia malayi | Choline O-acetyltransferase | 0.0124 | 0.0608 | 0.1031 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0107 | 0.0107 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1403 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1403 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.1403 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.1403 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 1.3 % | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux at 30 uM after 45 mins relative to glutamate | ChEMBL. | 23932792 |
IC50 (binding) | = 6.26 | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
IC50 (binding) | = 553 nM | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.