Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.042 | 0.4898 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0124 | 0.1234 | 0.1234 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.045 | 0.0243 |
Echinococcus granulosus | choline O acetyltransferase | 0.0124 | 0.1234 | 0.1044 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0309 | 0.3529 | 0.3322 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0815 | 0.9776 | 0.9776 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.042 | 0.4898 | 0.4788 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0833 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0833 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0833 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0124 | 0.1234 | 0.1234 |
Brugia malayi | Choline O-acetyltransferase | 0.0124 | 0.1234 | 0.1234 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.031 | 0.031 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.042 | 0.4898 | 0.4788 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.045 | 0.0243 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0124 | 0.1234 | 0.0953 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0124 | 0.1234 | 0.0953 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.042 | 0.4898 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0309 | 0.3529 | 0.3389 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0309 | 0.3529 | 0.6264 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0212 | 0.0212 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0124 | 0.1234 | 0.1234 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0309 | 0.3529 | 0.6264 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0833 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0833 | 1 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0309 | 0.3529 | 0.3529 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.045 | 0.0144 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.042 | 0.4898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1234 | 0.0953 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0309 | 0.3529 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0309 | 0.3529 | 0.3389 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.9776 | 0.9769 |
Schistosoma mansoni | choline o-acyltransferase | 0.0124 | 0.1234 | 0.1234 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0253 | 0.0253 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0124 | 0.1234 | 0.1044 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0833 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 0.7 % | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux at 30 uM after 45 mins relative to glutamate | ChEMBL. | 23932792 |
IC50 (binding) | = 6.11 | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
IC50 (binding) | = 769 nM | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.