Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.0475 | 0.0475 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0158 | 0.0957 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.0475 | 0.0475 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0259 | 0.0259 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.204 | 0.204 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | TDC-1 protein | 0.0158 | 0.0957 | 0.0957 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0259 | 0.0259 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0158 | 0.0957 | 0.5 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.1384 | 1 | 1 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0158 | 0.0957 | 0.0957 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0158 | 0.0957 | 0.0957 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0053 | 0.0053 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0499 | 0.0499 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.0499 | 0.0499 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0259 | 0.0259 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0158 | 0.0957 | 0.0957 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0053 | 0.0053 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0158 | 0.0957 | 0.0957 |
Brugia malayi | glutamate decarboxylase putative | 0.0158 | 0.0957 | 0.0957 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0158 | 0.0957 | 0.5 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0158 | 0.0957 | 0.0957 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0259 | 0.0259 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0158 | 0.0957 | 0.5 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0158 | 0.0957 | 0.0957 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.1384 | 1 | 1 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Echinococcus granulosus | snurportin 1 | 0.0305 | 0.204 | 0.204 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.1384 | 1 | 0.5 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0 | 0.5 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0389 | 0.0389 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1384 | 1 | 1 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.1384 | 1 | 1 |
Leishmania major | sphingosine 1-phosphate lyase | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0305 | 0.204 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0957 | 0.0957 |
Echinococcus multilocularis | snurportin 1 | 0.0305 | 0.204 | 0.204 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.0499 | 0.0499 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0053 | 0.0053 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.0499 | 0.0499 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0259 | 0.0259 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.0499 | 0.0499 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0158 | 0.0957 | 0.0957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | < 30 % | Antagonist activity at OX2 receptor (unknown origin) expressed in RD-HGA16 cells assessed as inhibition orexin A-induced calcium mobilization at 10 uM by fluorescence assay | ChEMBL. | 23941044 |
Ke(app) (functional) | = 6630 nM | Antagonist activity at OX1 receptor (unknown origin) expressed in RD-HGA16 cells assessed as inhibition orexin A-induced calcium mobilization by fluorescence assay | ChEMBL. | 23941044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.