Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | phenylalanine decarboxylase | 0.0188 | 0.098 | 0.098 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.164 | 1 | 1 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0188 | 0.098 | 0.098 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0188 | 0.098 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0188 | 0.098 | 0.098 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.0047 | 0.0047 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0188 | 0.098 | 0.098 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0188 | 0.098 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0438 | 0.0438 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.164 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.0227 | 0.0227 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.01 | 0.0438 | 0.0438 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.0047 | 0.0047 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0188 | 0.098 | 0.098 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0097 | 0.0417 | 0.0417 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0188 | 0.098 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0206 | 0.0206 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0188 | 0.098 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0097 | 0.0417 | 0.0417 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.0227 | 0.0227 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0188 | 0.098 | 0.098 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.1791 | 0.1791 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | TDC-1 protein | 0.0188 | 0.098 | 0.098 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.0227 | 0.0227 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0188 | 0.098 | 0.5 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0188 | 0.098 | 0.098 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.164 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0085 | 0.0341 | 0.0341 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.164 | 1 | 1 |
Leishmania major | sphingosine 1-phosphate lyase | 0.164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.098 | 0.098 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0318 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0047 | 0.0047 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0318 | 0.1791 | 0.1791 |
Schistosoma mansoni | transient receptor potential channel | 0.01 | 0.0438 | 0.0438 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.0227 | 0.0227 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.01 | 0.0438 | 0.0438 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0188 | 0.098 | 0.098 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.01 | 0.0438 | 0.0438 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0188 | 0.098 | 0.5 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0188 | 0.098 | 0.098 |
Brugia malayi | glutamate decarboxylase putative | 0.0188 | 0.098 | 0.098 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0188 | 0.098 | 0.098 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.0227 | 0.0227 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0188 | 0.098 | 0.5 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.164 | 1 | 1 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0188 | 0.098 | 0.098 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.164 | 1 | 1 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0188 | 0.098 | 0.098 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.164 | 1 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0318 | 0.1791 | 0.1791 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0188 | 0.098 | 0.098 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | > 32 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs | ChEMBL. | 23831506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.