TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.485 | Formula: C22H32O7
H donors: 4 H acceptors: 5 LogP: 0.46 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCO[C@@H]1O[C@@]2(O)[C@H]([C@H]3[C@@]1([C@@H](O)CCC3(C)C)[C@H]1[C@@]32[C@H](O)[C@@H](CC1)C(=C)C3=O)O
InChi: 1S/C22H32O7/c1-5-28-18-20-12-7-6-11-10(2)15(24)21(12,16(11)25)22(27,29-18)17(26)14(20)19(3,4)9-8-13(20)23/h11-14,16-18,23,25-27H,2,5-9H2,1,3-4H3/t11-,12-,13-,14+,16+,17-,18+,20-,21-,22-/m0/s1
InChiKey: CEINIYPVMZSXKB-UCMBFLOESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0167	0.0131	0.0131
Echinococcus granulosus	Sterile alpha motif SAM	0.0161	0.0126	0.0126
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0043	0.0018	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.0136	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0126	0.0126
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Brugia malayi	hypothetical protein	0.2035	0.1835	0.1835
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0041	0.0016	0.5
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0041	0.0016	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0043	0.0018	0.0018
Echinococcus multilocularis	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0094	0.0064	0.0064
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0169	0.0133	1
Onchocerca volvulus		0.0029	0.0005	0.0413
Echinococcus granulosus	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Echinococcus multilocularis	c src tyrosine kinase	0.0081	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0057	0.0057
Schistosoma mansoni	tyrosine kinase	0.0211	0.0171	0.0171
Echinococcus granulosus	tyrosine protein kinase Srms	0.0029	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0138	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0229	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0115	0.0084	0.0084
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0024	0.0024
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0161	0.0126	0.0126
Echinococcus granulosus	N chimaerin	0.0029	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0016	0.0016
Echinococcus granulosus	growth factor receptor bound protein 2	0.0043	0.0018	0.0018
Brugia malayi	C1-like domain containing protein	0.0069	0.0042	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0005	0.0005
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0161	0.0126	0.0126
Schistosoma mansoni	adapter molecule crk	0.0043	0.0018	0.0018
Echinococcus multilocularis	NCK adaptor protein	0.0043	0.0018	0.0018
Plasmodium falciparum	protein kinase, putative	0.0169	0.0133	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0094	0.0064	0.0064
Onchocerca volvulus		0.007	0.0042	0.3356
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0161	0.0126	0.0126
Echinococcus multilocularis	calcium release activated calcium channel	1.0988	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0029	0.0005	0.0005
Onchocerca volvulus		0.0029	0.0005	0.0413
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0005	0.0005
Echinococcus granulosus	stromal interaction molecule 1	0.2035	0.1835	0.1835
Echinococcus granulosus	tankyrase	0.0161	0.0126	0.0126
Echinococcus granulosus	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Onchocerca volvulus		0.006	0.0034	0.2678
Loa Loa (eye worm)	hypothetical protein	0.1645	0.1479	0.1479
Echinococcus multilocularis	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0043	0.0018	0.0018
Brugia malayi	Variant SH3 domain containing protein	0.0043	0.0018	0.0018
Schistosoma mansoni	tyrosine kinase	0.005	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0136	0.0103	0.0103
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0029	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0041	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	1.0988	1	1
Echinococcus granulosus	liprin alpha 2	0.0161	0.0126	0.0126
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0029	0.0005	0.0005
Schistosoma mansoni	caspase-7 (C14 family)	0.0041	0.0016	0.0016
Schistosoma mansoni	growth factor receptor-bound protein	0.0043	0.0018	0.0018
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0128	0.0095	0.0095
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0018	0.2137
Loa Loa (eye worm)	TK protein kinase	0.0094	0.0064	0.0064
Brugia malayi	Stress-activated protein kinase jnk-1	0.0229	0.0187	0.0187
Echinococcus multilocularis	liprin alpha 2	0.0161	0.0126	0.0126
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Brugia malayi	Sex muscle abnormal protein 5	0.0043	0.0018	0.0018
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0029	0.0005	0.0005
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0161	0.0126	1
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0005	0.0005
Echinococcus multilocularis	tyrosine kinase	0.0029	0.0005	0.0005
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0039	0.0015	0.0015
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.006	0.0034	0.0034
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Leishmania major	protein kinase A catalytic subunit	0.0041	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0136	0.0103	0.0103
Echinococcus multilocularis	stromal interaction molecule 1	0.2035	0.1835	0.1835
Echinococcus granulosus	c-Jun N-terminal kinases	0.0229	0.0187	0.0187
Loa Loa (eye worm)	SRC-1	0.0136	0.0103	0.0103
Brugia malayi	Neurabin protein 1	0.0161	0.0126	0.0126
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Brugia malayi	MH2 domain containing protein	0.0118	0.0086	0.0086
Brugia malayi	Tnks protein	0.0161	0.0126	0.0126
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0163	0.0127	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0043	0.0018	0.2137
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Onchocerca volvulus		0.0161	0.0126	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0115	0.0084	0.0084
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0041	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Onchocerca volvulus		0.0029	0.0005	0.0413
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0016	0.0016
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0229	0.0187	0.0187
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0041	0.0016	0.5
Schistosoma mansoni	hypothetical protein	0.0161	0.0126	0.0126
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0043	0.0018	0.0018
Brugia malayi	protein-tyrosine kinase	0.0115	0.0084	0.0084
Onchocerca volvulus	Cell death protein 3 homolog	0.0041	0.0016	0.1262
Echinococcus granulosus	tyrosine kinase	0.0029	0.0005	0.0005
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0029	0.0005	0.0005
Echinococcus multilocularis	tankyrase	0.0161	0.0126	0.0126
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0167	0.0131	0.0131
Schistosoma mansoni	growth factor receptor-bound protein	0.0043	0.0018	0.0018
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0161	0.0126	0.0126
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Echinococcus granulosus	geminin	0.0167	0.0131	0.0131
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0136	0.0103	0.0103
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0029	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0016	0.0016
Loa Loa (eye worm)	TK/ABL protein kinase	0.0233	0.0191	0.0191
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0041	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.0042	0.0042
Echinococcus granulosus	tyrosine protein kinase shark	0.0029	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0016	0.0016
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0136	0.0103	0.0103
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0041	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0126	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0041	0.0016	0.0016
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Loa Loa (eye worm)	TK/CSK protein kinase	0.0039	0.0014	0.0014
Entamoeba histolytica	protein kinase, putative	0.0094	0.0064	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0029	0.0005	0.0005
Brugia malayi	Cell death protein 3 precursor	0.0041	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.006	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0018	0.0018
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.005	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0108	0.0077	0.0077
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0069	0.0042	0.0042
Echinococcus granulosus	NCK adaptor protein	0.0043	0.0018	0.0018
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0233	0.0191	0.0191
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0108	0.0077	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0126	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Echinococcus granulosus	c src tyrosine kinase	0.0081	0.0053	0.0053
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0229	0.0187	0.0187
Giardia lamblia	Kinase, AGC PKA	0.0041	0.0016	0.5
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0041	0.0016	0.5
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0041	0.0016	0.0016
Schistosoma mansoni	protein kinase C mu	0.0069	0.0042	0.0042
Echinococcus granulosus	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0161	0.0126	0.0126
Echinococcus multilocularis	SAM domain containing protein	0.0161	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0068	0.004	0.004
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0233	0.0191	0.0191
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0016	0.0016
Echinococcus multilocularis	N chimaerin	0.0029	0.0005	0.0005
Echinococcus multilocularis	caspase 2	0.0041	0.0016	0.0016
Brugia malayi	SH2 domain containing protein	0.0029	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.0136	0.0103	0.0103
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0041	0.0016	0.5
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0016	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0136	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.2035	0.1835	0.1835
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0126	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Schistosoma mansoni	vav2	0.0031	0.0007	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0086	0.0086
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0005	0.0005
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0062	0.0035	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Brugia malayi	RhoGAP domain containing protein	0.0029	0.0005	0.0005
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0039	0.0015	0.0015
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0069	0.0042	0.0042
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0136	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0161	0.0126	0.0126
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0136	0.0103	0.0103
Echinococcus granulosus	tyrosine kinase	0.0115	0.0084	0.0084
Schistosoma mansoni	Protein orai-1	1.0988	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0136	0.0103	0.0103
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0024	0.0024
Plasmodium falciparum	tyrosine kinase-like protein	0.0169	0.0133	1
Schistosoma mansoni	sarm1	0.0161	0.0126	0.0126
Brugia malayi	coiled-coil like protein 1	0.0161	0.0126	0.0126
Schistosoma mansoni	hypothetical protein	0.1103	0.0985	0.0985
Brugia malayi	Liprin-alpha 2	0.0161	0.0126	0.0126
Brugia malayi	SH2 domain containing protein	0.006	0.0034	0.0034
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0136	0.0103	0.0103
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0136	0.0103	0.0103
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0136	0.0103	0.0103
Echinococcus multilocularis	geminin	0.0167	0.0131	0.0131
Echinococcus granulosus	caspase 2	0.0041	0.0016	0.0016
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0041	0.0016	0.5
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0041	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0126	0.0126
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Loa Loa (eye worm)	SH2 domain-containing protein	0.0053	0.0027	0.0027
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Blk	0.0115	0.0084	0.0084
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0115	0.0084	0.0084
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0029	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0115	0.0084	0.0084
Schistosoma mansoni	tankyrase	0.0161	0.0126	0.0126
Brugia malayi	hypothetical protein	0.0029	0.0005	0.0005
Echinococcus granulosus	liprin beta 1	0.0161	0.0126	0.0126
Echinococcus granulosus	SAM domain containing protein	0.0161	0.0126	0.0126
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0043	0.0018	0.0018
Onchocerca volvulus		0.0161	0.0126	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0161	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.1645	0.1479	0.1479
Schistosoma mansoni	tyrosine kinase	0.0081	0.0053	0.0053
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0086	0.0086
Schistosoma mansoni	hypothetical protein	0.0041	0.0016	0.0016
Brugia malayi	Tyrosine-protein kinase abl-1	0.0128	0.0095	0.0095
Onchocerca volvulus		0.006	0.0034	0.2669
Onchocerca volvulus		0.0041	0.0016	0.1262
Schistosoma mansoni	hypothetical protein	0.0161	0.0126	0.0126
Echinococcus granulosus	calcium release activated calcium channel	1.0988	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0029	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0932	0.0829	0.0829
Schistosoma mansoni	nck2/grb4	0.0043	0.0018	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0126	1
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0161	0.0126	0.0126
Echinococcus multilocularis	liprin beta 1	0.0161	0.0126	0.0126
Onchocerca volvulus		0.0029	0.0005	0.0413
Schistosoma mansoni	tyrosine kinase	0.0029	0.0005	0.0005
Onchocerca volvulus		0.0068	0.004	0.3209
Onchocerca volvulus		0.0029	0.0005	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0016	0.0016
Brugia malayi	SRC-1	0.0136	0.0103	0.0103
Schistosoma mansoni	tyrosine kinase	0.0029	0.0005	0.0005
Schistosoma mansoni	Protein orai-1	1.0988	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0126	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase csk	0.0039	0.0014	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0041	0.0016	0.0016
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0115	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0126	0.0126

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.9 uM	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess method	ChEMBL.	23819871
IC50 (functional)	= 7.8 uM	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	ChEMBL.	23819871

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23819871
Mus musculus	ChEMBL23	23819871

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2407383

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1771199