TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.343 | Formula: C17H22BrN3O4S
H donors: 2 H acceptors: 3 LogP: 2.8 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1c1nc(C(C)C)c(c(=O)[nH]1)Br)NS(=O)(=O)C
InChi: 1S/C17H22BrN3O4S/c1-5-8-25-13-7-6-11(21-26(4,23)24)9-12(13)16-19-15(10(2)3)14(18)17(22)20-16/h6-7,9-10,21H,5,8H2,1-4H3,(H,19,20,22)
InChiKey: ABPWYKOHDNIBTQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 6A, cGMP-specific, rod, alpha		References
Homo sapiens	phosphodiesterase 6B, cGMP-specific, rod, beta	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 6D, cGMP-specific, rod, delta		References
Homo sapiens	phosphodiesterase 6C, cGMP-specific, cone, alpha prime		References
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 6H, cGMP-specific, cone, gamma	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 6G, cGMP-specific, rod, gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132370	All targets in OG5_132370
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Brugia malayi	hypothetical protein	Get druggable targets OG5_132370	All targets in OG5_132370
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_132370	All targets in OG5_132370
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase	Get druggable targets OG5_132370	All targets in OG5_132370
Trichomonas vaginalis	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_132370	All targets in OG5_132370
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cAMP-specific phosphodiesterase	phosphodiesterase 6B, cGMP-specific, rod, beta	854 aa	805 aa	25.7 %
Trypanosoma brucei	Ras-related protein RAB2B, putative	phosphodiesterase 6D, cGMP-specific, rod, delta	93 aa	81 aa	28.4 %
Toxoplasma gondii	FATC domain-containing protein	phosphodiesterase 6G, cGMP-specific, rod, gamma	87 aa	71 aa	35.2 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	858 aa	763 aa	27.4 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	phosphodiesterase 6A, cGMP-specific, rod, alpha	860 aa	777 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0898	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.036	0.299	0.299
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.036	0.299	0.299
Echinococcus granulosus	natriuretic peptide receptor 1	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Plasmodium falciparum	protein kinase, putative	0.036	0.299	0.5
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0538	0.5315	0.3316
Loa Loa (eye worm)	TK/EPH protein kinase	0.036	0.299	0.299
Entamoeba histolytica	protein kinase, putative	0.0538	0.5315	0.3316
Loa Loa (eye worm)	TK/INSR protein kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine kinase	0.0898	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.036	0.299	1
Leishmania major	protein kinase, putative	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.036	0.299	0.299
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0538	0.5315	0.5315
Schistosoma mansoni	serine/threonine protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Guanylyl cyclase protein 23	0.036	0.299	0.299
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0538	0.5315	0.5315
Schistosoma mansoni	tensin-related	0.0538	0.5315	0.5315
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0898	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.036	0.299	1
Echinococcus granulosus	expressed conserved protein	0.0538	0.5315	0.5315
Echinococcus multilocularis	integrin linked protein kinase	0.036	0.299	0.299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	signal transduction protein lnk realted	0.0538	0.5315	0.5315
Brugia malayi	Variant SH3 domain containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	RGC/RGC protein kinase	0.036	0.299	0.299
Plasmodium falciparum	tyrosine kinase-like protein	0.036	0.299	0.5
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Schistosoma mansoni	vav2	0.0538	0.5315	0.5315
Onchocerca volvulus		0.0898	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0064	0.0214
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0898	1	1
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.036	0.299	0.299
Brugia malayi	integrin-linked kinase	0.036	0.299	0.299
Echinococcus multilocularis	protein kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.036	0.299	0.299
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	receptor type guanylyl cyclase	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0538	0.5315	0.5315
Leishmania major	protein kinase, putative	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase shark	0.0898	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0538	0.5315	0.5315
Echinococcus granulosus	SH2 motif	0.0538	0.5315	0.5315
Echinococcus multilocularis	insulin receptor	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0898	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0898	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.036	0.299	0.299
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0538	0.5315	0.5315
Toxoplasma gondii	STE kinase	0.036	0.299	1
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.036	0.299	0.299
Echinococcus multilocularis	tensin	0.0538	0.5315	0.5315
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.036	0.299	0.299
Brugia malayi	Sex muscle abnormal protein 5	0.0538	0.5315	0.5315
Brugia malayi	ephrin receptor 1 precursor	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0898	1	1
Schistosoma mansoni	SH2A	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Schistosoma mansoni	suppressor of cytokine signaling	0.0538	0.5315	0.5315
Onchocerca volvulus		0.0538	0.5315	0.3316
Loa Loa (eye worm)	SH2 domain-containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	hypothetical protein	0.036	0.299	0.299
Schistosoma mansoni	adapter molecule crk	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Giardia lamblia	Kinase	0.036	0.299	0.5
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Raf kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0898	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0898	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.036	0.299	0.299
Brugia malayi	protein-tyrosine kinase	0.0898	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0538	0.5315	0.5315
Entamoeba histolytica	SH2 domain containing protein	0.0538	0.5315	0.3316
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.036	0.299	1
Schistosoma mansoni	tyrosine protein kinase	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase pr2	0.036	0.299	0.299
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.036	0.299	0.299
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.036	0.299	0.299
Echinococcus multilocularis	transfer RNA-Thr	0.036	0.299	0.299
Echinococcus multilocularis	protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0538	0.5315	0.5315
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/Met protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	STE family protein kinase	0.036	0.299	1
Schistosoma mansoni	ephrin receptor	0.036	0.299	0.299
Echinococcus granulosus	activated cdc42 kinase 1	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0898	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.0898	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.036	0.299	0.299
Brugia malayi	SH2 domain containing protein	0.0898	1	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.036	0.299	0.299
Echinococcus multilocularis	tensin	0.0538	0.5315	0.5315
Echinococcus granulosus	retinal guanylyl cyclase 2	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0538	0.5315	0.5315
Echinococcus multilocularis	tyrosine protein kinase shark	0.0898	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.036	0.299	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus granulosus	tensin	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0898	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Brugia malayi	C-terminal src kinase protein 1	0.036	0.299	0.299
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	SH2 domain containing protein	0.0898	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0538	0.5315	0.5315
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Trichomonas vaginalis	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative	0.0342	0.2765	0.9248
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0898	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.036	0.299	0.299
Echinococcus granulosus	SH2 motif	0.0538	0.5315	0.5315
Plasmodium falciparum	tyrosine kinase-like protein	0.036	0.299	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.036	0.299	1
Onchocerca volvulus		0.0898	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.036	0.299	0.299
Schistosoma mansoni	tensin	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/CSK protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0898	1	1
Plasmodium falciparum	protein kinase, putative	0.036	0.299	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine kinase	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Onchocerca volvulus		0.0898	1	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Brugia malayi	Tensin	0.0538	0.5315	0.5315
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.036	0.299	0.299
Schistosoma mansoni	growth factor receptor-bound protein	0.0538	0.5315	0.5315
Echinococcus multilocularis	N chimaerin	0.0538	0.5315	0.5315
Echinococcus granulosus	tyrosine protein kinase csk	0.036	0.299	0.299
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0898	1	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Brugia malayi	Variant SH3 domain containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.036	0.299	0.299
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.036	0.299	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus multilocularis	kinase suppressor of Ras 1	0.036	0.299	0.299
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0538	0.5315	0.5315
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.036	0.299	0.299
Loa Loa (eye worm)	STAT protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus granulosus	insulin receptor	0.036	0.299	0.299
Giardia lamblia	Kinase, NEK	0.036	0.299	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0898	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.036	0.299	0.299
Schistosoma mansoni	hypothetical protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Leishmania major	hypothetical protein, conserved	0.036	0.299	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0538	0.5315	0.5315
Brugia malayi	hypothetical protein	0.0538	0.5315	0.5315
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	CAMK family protein kinase	0.036	0.299	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0898	1	1
Schistosoma mansoni	retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase	0.0342	0.2765	0.2765
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase csk	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	protein kinase atn1, putative	0.036	0.299	1
Schistosoma mansoni	serine/threonine protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/RYK protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Trypanosoma cruzi	protein kinase, putative	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Schistosoma mansoni	protein tyrosine kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0898	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0898	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0064	0.0214
Echinococcus granulosus	fibroblast growth factor receptor 4	0.036	0.299	0.299
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.036	0.299	0.299
Echinococcus granulosus	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	SHC transforming protein 3	0.0538	0.5315	0.5315
Echinococcus granulosus	raf serine:threonine protein kinase	0.036	0.299	0.299
Echinococcus granulosus	growth factor receptor bound protein 2	0.0538	0.5315	0.5315
Loa Loa (eye worm)	SRC-1	0.0898	1	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	serine/threonine protein kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.036	0.299	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0171	0.0536	0.0536
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Toxoplasma gondii	protein kinase	0.036	0.299	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0538	0.5315	0.5315
Brugia malayi	bone morphogenetic protein type 1 receptor	0.036	0.299	0.299
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Echinococcus granulosus	activin receptor type	0.036	0.299	0.299
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.036	0.299	0.299
Loa Loa (eye worm)	TK/ALK protein kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase csk	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Plasmodium falciparum	protein kinase, putative	0.036	0.299	0.5
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus granulosus	N chimaerin	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Onchocerca volvulus		0.0898	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.036	0.299	0.299
Echinococcus multilocularis	activated cdc42 kinase 1	0.036	0.299	0.299
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Schistosoma mansoni	GTPase activating protein	0.0538	0.5315	0.5315
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0538	0.5315	0.5315
Echinococcus granulosus	ephrin type A receptor 4 A	0.036	0.299	0.299
Onchocerca volvulus		0.0538	0.5315	0.3316
Loa Loa (eye worm)	RGC/RGC protein kinase	0.036	0.299	0.299
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0538	0.5315	0.5315
Brugia malayi	RhoGAP domain containing protein	0.0538	0.5315	0.5315
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.036	0.299	0.299
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0538	0.5315	0.5315
Giardia lamblia	Kinase, NEK	0.036	0.299	0.5
Trypanosoma cruzi	protein kinase, putative	0.036	0.299	1
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus granulosus	integrin linked protein kinase	0.036	0.299	0.299
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0898	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0536	0.1793
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Trypanosoma brucei	Pseudokinase, putative	0.036	0.299	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0538	0.5315	0.5315
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/ABL protein kinase	0.0898	1	1
Echinococcus granulosus	hypothetical protein	0.0538	0.5315	0.5315
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0898	1	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.0898	1	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.0898	1	1
Brugia malayi	hypothetical protein	0.036	0.299	0.299
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0171	0.0536	0.0536
Echinococcus multilocularis	c src tyrosine kinase	0.0898	1	1
Onchocerca volvulus		0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Plasmodium vivax	tyrosine kinase-like protein, putative	0.036	0.299	0.5
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0342	0.2765	0.2765
Echinococcus multilocularis	SH2 motif	0.0538	0.5315	0.5315
Echinococcus multilocularis	NCK adaptor protein	0.0538	0.5315	0.5315
Echinococcus multilocularis	epidermal growth factor receptor	0.036	0.299	0.299
Loa Loa (eye worm)	TK/DDR protein kinase	0.036	0.299	0.299
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	protein tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	SH2 motif	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0538	0.5315	0.3316
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	SH2 motif	0.0538	0.5315	0.5315
Echinococcus granulosus	retinal guanylyl cyclase 2	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine kinase	0.036	0.299	0.299
Schistosoma mansoni	nck2/grb4	0.0538	0.5315	0.5315
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0538	0.5315	0.5315
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Brugia malayi	Receptor family ligand binding region containing protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.036	0.299	0.299
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.036	0.299	0.299
Plasmodium vivax	tyrosine kinase-like protein, putative	0.036	0.299	0.5
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Schistosoma mansoni	serine/threonine protein kinase	0.036	0.299	0.299
Echinococcus granulosus	receptor type guanylyl cyclase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.036	0.299	0.299
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.036	0.299	0.299
Plasmodium vivax	protein kinase, putative	0.036	0.299	0.5
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0898	1	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0538	0.5315	0.5315
Schistosoma mansoni	tensin	0.0538	0.5315	0.5315
Onchocerca volvulus		0.0538	0.5315	0.3316
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Onchocerca volvulus		0.0538	0.5315	0.3316
Echinococcus granulosus	retinal guanylyl cyclase 2	0.036	0.299	0.299
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.036	0.299	1
Brugia malayi	SRC-1	0.0898	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TK family protein kinase	0.036	0.299	1
Brugia malayi	Variant SH3 domain containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Schistosoma mansoni	ephrin receptor	0.036	0.299	0.299
Onchocerca volvulus		0.0898	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0538	0.5315	0.5315
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	RGC/RGC protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase Srms	0.0898	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0538	0.5315	0.5315
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.036	0.299	0.299
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	TK/ROR protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Trypanosoma brucei	Flagellum attachment zone protein 20	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Loa Loa (eye worm)	hypothetical protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	TK protein kinase	0.0898	1	1
Brugia malayi	hypothetical protein	0.0898	1	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.036	0.299	0.299
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0898	1	1
Schistosoma mansoni	protein kinase	0.036	0.299	0.299
Giardia lamblia	Protein 21.1	0.036	0.299	0.5
Trichomonas vaginalis	AGC family protein kinase	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus granulosus	SH2 domain containing protein 7	0.0538	0.5315	0.5315
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	epidermal growth factor receptor	0.036	0.299	0.299
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	hypothetical protein	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase pr2	0.036	0.299	0.299
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0538	0.5315	0.5315
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.036	0.299	0.299
Schistosoma mansoni	tensin	0.0538	0.5315	0.5315
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0898	1	1
Brugia malayi	hypothetical protein	0.0342	0.2765	0.2765
Echinococcus multilocularis		0.0538	0.5315	0.5315
Echinococcus multilocularis	FL cytokine receptor	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein kinase HCK	0.036	0.299	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Loa Loa (eye worm)	hypothetical protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	protein kinase domain-containing protein	0.036	0.299	0.299
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0538	0.5315	0.5315
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Variant SH3 domain containing protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.036	0.299	0.299
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Onchocerca volvulus		0.0538	0.5315	0.3316
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	hypothetical protein	0.0538	0.5315	0.5315
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0171	0.0536	0.1793
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0898	1	1
Schistosoma mansoni	serine/threonine RGC	0.036	0.299	0.299
Echinococcus granulosus	protein tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0898	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Trichomonas vaginalis	protein tyrosine kinase, putative	0.036	0.299	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0898	1	1
Echinococcus granulosus	tyrosine protein kinase	0.036	0.299	0.299
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0538	0.5315	0.5315
Brugia malayi	Tyrosine-protein kinase abl-1	0.0898	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0064	0.0214
Brugia malayi	SH2 domain containing protein	0.0538	0.5315	0.5315
Loa Loa (eye worm)	TK/FER protein kinase	0.0898	1	1
Echinococcus granulosus	NCK adaptor protein	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.0898	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0538	0.5315	0.3316
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0898	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.036	0.299	0.299
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0538	0.5315	0.5315
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Echinococcus granulosus	tyrosine kinase	0.0898	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.036	0.299	0.299
Loa Loa (eye worm)	TK protein kinase	0.036	0.299	0.299
Toxoplasma gondii	protein kinase domain-containing protein	0.036	0.299	1
Echinococcus multilocularis	activin receptor type	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus multilocularis	raf serine:threonine protein kinase	0.036	0.299	0.299
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0171	0.0536	0.0536
Schistosoma mansoni	tensin-related	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Echinococcus granulosus	protein kinase	0.036	0.299	0.299
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0538	0.5315	0.5315
Brugia malayi	Protein kinase domain containing protein	0.036	0.299	0.299
Schistosoma mansoni	tyrosine kinase	0.0898	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0898	1	1
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Schistosoma mansoni	shc transforming protein	0.0538	0.5315	0.5315
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0538	0.5315	0.5315
Trichomonas vaginalis	conserved hypothetical protein	0.036	0.299	1
Trypanosoma brucei	protein kinase, putative	0.036	0.299	1
Schistosoma mansoni	tyrosine kinase	0.036	0.299	0.299
Echinococcus multilocularis	heat shock protein 70	0.036	0.299	0.299
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0171	0.0536	0.1793
Echinococcus multilocularis	ephrin type A receptor 4 A	0.036	0.299	0.299
Trichomonas vaginalis	TKL family protein kinase	0.036	0.299	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.036	0.299	0.299
Onchocerca volvulus		0.0538	0.5315	0.3316
Loa Loa (eye worm)	SH2 domain-containing protein	0.0538	0.5315	0.5315

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.7 nM	Inhibition of PDE5 (unknown origin)	ChEMBL.	23867165
IC50 (binding)	= 1600 nM	Inhibition of PDE6 (unknown origin)	ChEMBL.	23867165

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2414316

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1772543