Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.2688 | 0.5593 | 0.5 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0326 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4477 | 0.9818 | 0.9818 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2688 | 0.5593 | 1 |
Onchocerca volvulus | 0.4554 | 1 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4477 | 0.9818 | 0.9706 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Loa Loa (eye worm) | raf kinase | 0.2145 | 0.431 | 0.431 |
Schistosoma mansoni | protein kinase | 0.0326 | 0.0015 | 0.0015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0442 | 0.0289 | 0.0289 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.1222 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0326 | 0.0015 | 0.0015 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4554 | 1 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1043 | 0.1043 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 0.0025 | 0.0025 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Brugia malayi | Protein kinase domain | 0.0768 | 0.1058 | 0.2546 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.0025 | 0.0025 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0326 | 0.0015 | 0.0036 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2688 | 0.5593 | 0.5 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Entamoeba histolytica | p21-activated kinase | 0.0768 | 0.1058 | 0.1892 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0448 | 0.0304 | 0.2768 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0448 | 0.0304 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.4554 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0761 | 0.1043 | 0.9857 |
Brugia malayi | Raf kinase | 0.208 | 0.4157 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4477 | 0.9818 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.2611 | 0.5411 | 0.5411 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4554 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Entamoeba histolytica | protein kinase, putative | 0.0768 | 0.1058 | 0.1892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 1.48 % ID/g | Biodistribution in Tg2576 ddY mouse brain at 23.4 to 48.2 kBq, iv measured at 60 mins by autoradiography | ChEMBL. | 24900717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.