Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2688 | 0.5593 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0326 | 0.0015 | 0.0036 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Entamoeba histolytica | protein kinase, putative | 0.0768 | 0.1058 | 0.1892 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0761 | 0.1043 | 0.9857 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4477 | 0.9818 | 0.9706 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 0.0025 | 0.0025 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0326 | 0.0015 | 0.0015 |
Onchocerca volvulus | 0.4554 | 1 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.0025 | 0.0025 |
Brugia malayi | Raf kinase | 0.208 | 0.4157 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4554 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4554 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Brugia malayi | Protein kinase domain | 0.0768 | 0.1058 | 0.2546 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4477 | 0.9818 | 0.9818 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0448 | 0.0304 | 0.2768 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0448 | 0.0304 | 0.0731 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Entamoeba histolytica | p21-activated kinase | 0.0768 | 0.1058 | 0.1892 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2688 | 0.5593 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.4554 | 1 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1043 | 0.1043 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0326 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.2611 | 0.5411 | 0.5411 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0442 | 0.0289 | 0.0289 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Loa Loa (eye worm) | raf kinase | 0.2145 | 0.431 | 0.431 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.1222 | 0.2131 | 0.2131 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4477 | 0.9818 | 0.9706 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.2688 | 0.5593 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0326 | 0.0015 | 0.0015 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 1.48 % ID/g | Biodistribution in Tg2576 ddY mouse brain at 23.4 to 48.2 kBq, iv measured at 60 mins by autoradiography | ChEMBL. | 24900717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.