Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.2688 | 0.5593 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4477 | 0.9818 | 0.9818 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0326 | 0.0015 | 0.0015 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4477 | 0.9818 | 0.9706 |
Onchocerca volvulus | 0.4554 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2688 | 0.5593 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0442 | 0.0289 | 0.0289 |
Schistosoma mansoni | protein kinase | 0.0326 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | raf kinase | 0.2145 | 0.431 | 0.431 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.1222 | 0.2131 | 0.2131 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0326 | 0.0015 | 0.0015 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4554 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Brugia malayi | Protein kinase domain | 0.0768 | 0.1058 | 0.2546 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1043 | 0.1043 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2688 | 0.5593 | 0.5 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0326 | 0.0015 | 0.0036 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.0025 | 0.0025 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Entamoeba histolytica | p21-activated kinase | 0.0768 | 0.1058 | 0.1892 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0448 | 0.0304 | 0.2768 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0448 | 0.0304 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.4554 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.2611 | 0.5411 | 0.5411 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4477 | 0.9818 | 0.9706 |
Brugia malayi | Raf kinase | 0.208 | 0.4157 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0761 | 0.1043 | 0.9857 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Entamoeba histolytica | protein kinase, putative | 0.0768 | 0.1058 | 0.1892 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4554 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 1.48 % ID/g | Biodistribution in Tg2576 ddY mouse brain at 23.4 to 48.2 kBq, iv measured at 60 mins by autoradiography | ChEMBL. | 24900717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.