Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.4554 | 1 | 0.5 | |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0448 | 0.0304 | 0.0731 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.0025 | 0.0025 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4554 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0768 | 0.1058 | 0.1892 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4554 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4477 | 0.9818 | 0.9818 |
Schistosoma mansoni | protein kinase | 0.0326 | 0.0015 | 0.0015 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Schistosoma mansoni | serine/threonine protein kinase | 0.033 | 0.0025 | 0.0025 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0761 | 0.1043 | 0.9857 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4477 | 0.9818 | 0.9706 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0326 | 0.0015 | 0.0015 |
Brugia malayi | Protein kinase domain | 0.0768 | 0.1058 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1043 | 0.1043 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4477 | 0.9818 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4554 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Schistosoma mansoni | protein kinase | 0.0768 | 0.1058 | 0.1058 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2688 | 0.5593 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Entamoeba histolytica | p21-activated kinase | 0.0768 | 0.1058 | 0.1892 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.1222 | 0.2131 | 0.2131 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0326 | 0.0015 | 0.0036 |
Giardia lamblia | Hypothetical protein | 0.2688 | 0.5593 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4554 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0448 | 0.0304 | 0.0304 |
Mycobacterium ulcerans | hypothetical protein | 0.2688 | 0.5593 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1943 | 0.3834 | 0.3641 |
Entamoeba histolytica | protein kinase, putative | 0.0326 | 0.0015 | 0.0027 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.2155 | 0.4335 | 0.4335 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2688 | 0.5593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2611 | 0.5411 | 0.5411 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0326 | 0.0015 | 0.0015 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0442 | 0.0289 | 0.0289 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | raf kinase | 0.2145 | 0.431 | 0.431 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0448 | 0.0304 | 0.0304 |
Trichomonas vaginalis | STE family protein kinase | 0.0768 | 0.1058 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0768 | 0.1058 | 0.1058 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Brugia malayi | Raf kinase | 0.208 | 0.4157 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4477 | 0.9818 | 0.9813 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0768 | 0.1058 | 0.1058 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0448 | 0.0304 | 0.2768 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 1.48 % ID/g | Biodistribution in Tg2576 ddY mouse brain at 23.4 to 48.2 kBq, iv measured at 60 mins by autoradiography | ChEMBL. | 24900717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.