TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 404.419 | Formula: C22H20N4O4
H donors: 2 H acceptors: 3 LogP: 1.56 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C3)C(=O)c1cnoc1C)/C(=O)N2
InChi: 1S/C22H20N4O4/c1-12-18(10-23-30-12)22(28)26-6-5-19-13(11-26)7-14(24-19)8-17-16-9-15(29-2)3-4-20(16)25-21(17)27/h3-4,7-10,24H,5-6,11H2,1-2H3,(H,25,27)/b17-8-
InChiKey: CNYOFMNBFMTOHX-IUXPMGMMSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leucine-rich repeat kinase 2	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	anaplastic lymphoma receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	platelet-derived growth factor receptor, alpha polypeptide	Starlite/ChEMBL	References
Homo sapiens	ret proto-oncogene	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TKL/LRRK protein kinase	Get druggable targets OG5_131478	All targets in OG5_131478
Loa Loa (eye worm)	TK/ALK protein kinase	Get druggable targets OG5_132231	All targets in OG5_132231
Echinococcus granulosus	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131478	All targets in OG5_131478
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_132231	All targets in OG5_132231
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132231	All targets in OG5_132231
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.003	0.0122	0.0178
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0449	0.4524	0.4524
Schistosoma mansoni	ephrin receptor	0.0183	0.1726	0.3815
Schistosoma mansoni	glutamate receptor kainate	0.028	0.2748	0.6074
Echinococcus multilocularis	nmda type glutamate receptor	0.0139	0.1262	0.1262
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	transfer RNA-Thr	0.0183	0.1726	0.1726
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus multilocularis	tyrosine protein kinase shark	0.0444	0.4478	0.4478
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0261	0.2553	0.2553
Echinococcus multilocularis	glutamate receptor 2	0.028	0.2748	0.2748
Echinococcus multilocularis	aldo keto reductase	0.003	0.0122	0.0122
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.028	0.2748	0.2748
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Schistosoma mansoni	serine/threonine protein kinase	0.0183	0.1726	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	RhoGAP domain containing protein	0.0261	0.2553	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Brugia malayi	hypothetical protein	0.0444	0.4478	0.9478
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	raf serine:threonine protein kinase	0.0183	0.1726	0.1759
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0261	0.2553	0.2602
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0183	0.1726	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	ankyrin repeat protein	0.0183	0.1726	0.3683
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.007	0.0541	0.0541
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Onchocerca volvulus		0.0183	0.1726	0.3683
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0183	0.1726	0.1759
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	ephrin receptor 1 precursor	0.0183	0.1726	0.349
Trichomonas vaginalis	TK family protein kinase	0.0183	0.1726	0.9963
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.068	0.696	1
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Entamoeba histolytica	hypothetical protein, conserved	0.0183	0.1726	0.3683
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0183	0.1726	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	hypothetical protein	0.0034	0.0159	0.0352
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0183	0.1726	0.1759
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0183	0.1726	0.349
Brugia malayi	SRC-1	0.0449	0.4524	0.9579
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0261	0.2553	0.2553
Onchocerca volvulus		0.0444	0.4478	1
Echinococcus multilocularis	SH2 motif	0.0261	0.2553	0.2553
Echinococcus granulosus	activated cdc42 kinase 1	0.0183	0.1726	0.1759
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	tyrosine kinase	0.0322	0.3187	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0444	0.4478	0.9489
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Echinococcus granulosus	N chimaerin	0.0261	0.2553	0.2602
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0261	0.2553	0.2602
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.019	0.1807	0.1807
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0449	0.4526	0.4614
Echinococcus multilocularis	tyrosine protein kinase	0.0183	0.1726	0.1726
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0449	0.4524	0.4524
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.006	0.043	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Giardia lamblia	Kinase, NEK	0.0183	0.1726	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Brugia malayi	hypothetical protein	0.0261	0.2553	0.5289
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0183	0.1727	0.3685
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0262	0.2555	0.5585
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0449	0.4524	0.4524
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0289	0.2841	0.2896
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.2553	0.5374
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0261	0.2553	0.2602
Onchocerca volvulus		0.0261	0.2553	0.5581
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0183	0.1726	0.1759
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0261	0.2553	0.2553
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus multilocularis	tyrosine kinase	0.0322	0.3187	0.3187
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0266	0.2599	0.5474
Echinococcus granulosus	SHC transforming protein 3	0.0261	0.2553	0.2602
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.2553	0.5374
Loa Loa (eye worm)	oxidoreductase	0.003	0.0122	0.0178
Echinococcus multilocularis	epidermal growth factor receptor	0.0183	0.1726	0.1726
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0183	0.1726	0.1726
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus granulosus	SH2 motif	0.0261	0.2553	0.2602
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Leishmania major	hypothetical protein, conserved	0.0183	0.1726	0.9988
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	glutamate receptor 2	0.028	0.2748	0.5792
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0322	0.3187	0.7037
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0449	0.4524	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0261	0.2553	0.2602
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0183	0.1726	0.3683
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0183	0.1726	0.1759
Schistosoma mansoni	serine/threonine protein kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	SH2 motif	0.0261	0.2553	0.2602
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Onchocerca volvulus		0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Schistosoma mansoni	tensin-related	0.0261	0.2553	0.5642
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0444	0.4478	0.4478
Echinococcus granulosus	MAM	0.0034	0.0159	0.0162
Schistosoma mansoni	shc transforming protein	0.0261	0.2553	0.5642
Schistosoma mansoni	serine/threonine RGC	0.0183	0.1726	0.3815
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Echinococcus granulosus	roundabout 2	0.0023	0.0039	0.0039
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0364	0.3638	0.7694
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0261	0.2553	0.5642
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus granulosus	activated cdc42 kinase 1	0.0183	0.1726	0.1759
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	MAM	0.0034	0.0159	0.0159
Schistosoma mansoni	signal transduction protein lnk-related	0.0261	0.2553	0.5642
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Echinococcus multilocularis	N chimaerin	0.0261	0.2553	0.2553
Echinococcus multilocularis	tensin	0.0261	0.2553	0.2553
Brugia malayi	RNA binding protein	0.006	0.043	0.0671
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0261	0.2553	0.5289
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0139	0.1262	0.2616
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Loa Loa (eye worm)	oxidoreductase	0.003	0.0122	0.0178
Brugia malayi	protein-tyrosine kinase	0.0444	0.4478	0.9478
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.019	0.1807	0.1842
Loa Loa (eye worm)	TK/ABL protein kinase	0.0444	0.4478	0.9489
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0449	0.4524	0.4524
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0449	0.4524	0.4612
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0261	0.2553	0.2602
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0444	0.4478	0.4478
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0261	0.2553	0.5581
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0261	0.2553	0.5374
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Brugia malayi	Protein kinase domain containing protein	0.0444	0.4478	0.9478
Schistosoma mansoni	hypothetical protein	0.0183	0.1726	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.068	0.696	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0261	0.2553	0.2602
Echinococcus multilocularis	tensin	0.0261	0.2553	0.2553
Echinococcus multilocularis	glutamate receptor 2	0.0148	0.1359	0.1359
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0139	0.1262	0.2481
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0183	0.1726	0.349
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0183	0.1726	0.1759
Brugia malayi	Variant SH3 domain containing protein	0.0266	0.2599	0.5391
Echinococcus granulosus	epidermal growth factor receptor	0.0183	0.1726	0.1759
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0183	0.1726	0.1759
Loa Loa (eye worm)	TK/ROR protein kinase	0.019	0.1807	0.3779
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1773	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Brugia malayi	Receptor family ligand binding region containing protein	0.0139	0.1262	0.2481
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0444	0.4478	0.4478
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Loa Loa (eye worm)	TK protein kinase	0.0444	0.4478	0.9489
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0183	0.1726	0.349
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0449	0.4524	0.4524
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0261	0.2553	0.2602
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0271	0.2651	0.586
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0261	0.2553	0.2553
Brugia malayi	Protein kinase domain containing protein	0.007	0.0541	0.0912
Onchocerca volvulus		0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0444	0.4478	0.4478
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Echinococcus granulosus	protein kinase	0.0183	0.1726	0.1759
Echinococcus multilocularis	signal transduction protein lnk realted	0.0261	0.2553	0.2553
Schistosoma mansoni	tensin-related	0.0261	0.2553	0.5642
Schistosoma mansoni	glutamate receptor NMDA	0.028	0.2748	0.6074
Schistosoma mansoni	protein tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0183	0.1728	1
Brugia malayi	sulfakinin receptor protein	0.0138	0.1254	0.2463
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0183	0.1726	0.9963
Trichomonas vaginalis	CAMK family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0183	0.1726	0.349
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0139	0.1262	0.1262
Echinococcus granulosus	activin receptor type	0.0183	0.1728	0.1761
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0437	0.4399	0.4484
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1728	0.3687
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Schistosoma mansoni	tyrosine protein kinase	0.0183	0.1726	0.3815
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	nmda type glutamate receptor	0.0139	0.1262	0.1287
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0261	0.2553	0.5289
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0183	0.1726	0.349
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0139	0.1262	0.2616
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0449	0.4524	0.4524
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0449	0.4524	0.4524
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Loa Loa (eye worm)	SH2 domain-containing protein	0.0261	0.2553	0.5374
Plasmodium vivax	protein kinase, putative	0.0183	0.1726	0.5
Schistosoma mansoni	adapter molecule crk	0.0266	0.2599	0.5745
Loa Loa (eye worm)	glutamate receptor	0.0139	0.1262	0.2616
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	vav2	0.0261	0.2553	0.5642
Trypanosoma cruzi	extracellular receptor, putative	0.0139	0.1262	0.7099
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Brugia malayi	integrin-linked kinase	0.0183	0.1726	0.349
Schistosoma mansoni	tyrosine kinase	0.0449	0.4524	1
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Entamoeba histolytica	hypothetical protein	0.0183	0.1727	0.3685
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0364	0.3638	0.765
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0261	0.2553	0.5289
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0261	0.2553	0.2553
Entamoeba histolytica	protein kinase, putative	0.0183	0.1727	0.3685
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0139	0.1262	0.1262
Brugia malayi	RNA recognition motif domain containing protein	0.006	0.043	0.0671
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0183	0.1726	0.1726
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	SH2 domain containing protein 7	0.0261	0.2553	0.2602
Entamoeba histolytica	tyrosin kinase, putative	0.0183	0.1726	0.3683
Trypanosoma cruzi	protein kinase, putative	0.0183	0.1726	0.9988
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0139	0.1262	0.1287
Schistosoma mansoni	growth factor receptor-bound protein	0.0266	0.2599	0.5745
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0449	0.4524	0.4612
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Echinococcus granulosus	tyrosine protein kinase pr2	0.0183	0.1726	0.1759
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0444	0.4478	1
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	tyrosine protein kinase	0.0183	0.1726	0.1759
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0271	0.2651	0.2702
Loa Loa (eye worm)	hypothetical protein	0.003	0.0122	0.0178
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Schistosoma mansoni	tyrosine kinase	0.0449	0.4524	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Onchocerca volvulus		0.0183	0.1726	0.3683
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0183	0.1726	0.349
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0183	0.1728	0.1761
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0139	0.1262	0.1287
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0271	0.2651	0.2702
Entamoeba histolytica	receptor protein kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	hypothetical protein	0.0139	0.1262	0.2618
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.025	0.2434	0.512
Onchocerca volvulus		0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Entamoeba histolytica	ankyrin repeat protein	0.0183	0.1726	0.3683
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0271	0.2651	0.2651
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Trypanosoma cruzi	protein kinase, putative	0.0183	0.1726	0.9988
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0183	0.1726	0.3815
Echinococcus multilocularis		0.0261	0.2553	0.2553
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Entamoeba histolytica	receptor protein kinase, putative	0.0183	0.1726	0.3683
Onchocerca volvulus		0.0139	0.1262	0.2618
Echinococcus granulosus	nmda type glutamate receptor	0.0951	0.981	1
Echinococcus multilocularis	heat shock protein 70	0.0183	0.1726	0.1726
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0071	0.0546	0.0557
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0449	0.4524	0.4612
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0183	0.1726	0.9988
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Schistosoma mansoni	SH2A	0.0261	0.2553	0.5642
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	Receptor family ligand binding region containing protein	0.0322	0.3187	0.6669
Schistosoma mansoni	tyrosine kinase	0.0322	0.3187	0.7044
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0183	0.1726	0.9963
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.2553	0.5289
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.003	0.0122	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.4524	1
Brugia malayi	Protein kinase domain containing protein	0.0444	0.4478	0.9478
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0444	0.4478	0.4478
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0322	0.3187	0.673
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0261	0.2553	0.2553
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	ephrin receptor	0.0183	0.1726	0.3815
Schistosoma mansoni	tensin	0.0261	0.2553	0.5642
Echinococcus granulosus	kinase suppressor of Ras 1	0.0183	0.1726	0.1759
Echinococcus multilocularis	aldo keto reductase	0.003	0.0122	0.0122
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0266	0.2599	0.5745
Onchocerca volvulus		0.0444	0.4478	1
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0183	0.1726	0.1726
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0183	0.1726	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0449	0.4524	0.4612
Brugia malayi	Immunoglobulin I-set domain containing protein	0.019	0.1807	0.3666
Onchocerca volvulus		0.0034	0.0159	0.0086
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	hypothetical protein	0.0261	0.2553	0.2602
Echinococcus multilocularis	c src tyrosine kinase	0.0449	0.4524	0.4524
Giardia lamblia	Kinase	0.0183	0.1726	1
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0139	0.1262	0.2481
Echinococcus granulosus	tyrosine protein kinase csk	0.0183	0.1726	0.1759
Echinococcus granulosus	glutamate receptor 2	0.0419	0.4209	0.429
Schistosoma mansoni	suppressor of cytokine signaling	0.0261	0.2553	0.5642
Echinococcus multilocularis	protein kinase	0.0183	0.1726	0.1726
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Schistosoma mansoni	glutamate receptor NMDA	0.0419	0.4209	0.9303
Schistosoma mansoni	glutamate receptor AMPA	0.028	0.2748	0.6074
Schistosoma mansoni	tyrosine kinase	0.0444	0.4478	0.9897
Onchocerca volvulus		0.0444	0.4478	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	hypothetical protein	0.003	0.0122	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Entamoeba histolytica	SH2 domain containing protein	0.0261	0.2553	0.5581
Brugia malayi	Protein kinase domain containing protein	0.0444	0.4478	0.9478
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0139	0.1262	0.2616
Onchocerca volvulus		0.0444	0.4478	1
Toxoplasma gondii	protein kinase	0.0183	0.1726	0.9988
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	Variant SH3 domain containing protein	0.0266	0.2599	0.5391
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Echinococcus granulosus	natriuretic peptide receptor 1	0.0183	0.1726	0.1759
Echinococcus granulosus	aldo keto reductase	0.003	0.0122	0.0124
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0183	0.1726	0.1726
Loa Loa (eye worm)	TK/CSK protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0322	0.3187	0.3187
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0183	0.1726	0.1759
Toxoplasma gondii	STE kinase	0.0183	0.1726	0.9988
Brugia malayi	Glutamate receptor 2 precursor	0.028	0.2748	0.5714
Brugia malayi	Glutamate receptor 1 precursor	0.028	0.2748	0.5714
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0183	0.1726	0.1726
Schistosoma mansoni	GTPase activating protein	0.0261	0.2553	0.5642
Loa Loa (eye worm)	TK/Met protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	nmda type glutamate receptor	0.0951	0.981	0.981
Loa Loa (eye worm)	oxidoreductase	0.003	0.0122	0.0178
Onchocerca volvulus		0.0444	0.4478	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0266	0.2599	0.265
Onchocerca volvulus		0.0034	0.0159	0.0086
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0437	0.4399	0.4484
Echinococcus multilocularis	tyrosine protein kinase csk	0.0183	0.1726	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0183	0.1726	0.1759
Schistosoma mansoni	tyrosine kinase	0.0444	0.4478	0.9897
Giardia lamblia	Protein 21.1	0.0183	0.1726	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	epidermal growth factor receptor	0.0183	0.1726	0.1759
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	activin receptor type	0.0183	0.1728	0.1728
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0261	0.2553	0.5374
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	roundabout 2	0.0023	0.0039	0.0039
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.068	0.696	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0183	0.1726	0.1759
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.068	0.696	0.5
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.007	0.0541	0.1074
Echinococcus granulosus	signal transduction protein lnk realted	0.0261	0.2553	0.2602
Onchocerca volvulus		0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0266	0.2599	0.5474
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Onchocerca volvulus		0.0261	0.2553	0.5581
Echinococcus granulosus	aldo keto reductase	0.003	0.0122	0.0124
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Echinococcus multilocularis	NMDA receptor	0.0289	0.2841	0.2841
Entamoeba histolytica	tyrosin kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0139	0.1262	0.1287
Chlamydia trachomatis	glutamine binding protein	0.068	0.696	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0183	0.1726	0.1759
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Entamoeba histolytica	hypothetical protein	0.0183	0.1727	0.3685
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0322	0.3187	0.673
Trichomonas vaginalis	STE family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0449	0.4524	0.4524
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0183	0.1726	0.349
Brugia malayi	Protein kinase domain containing protein	0.0467	0.4718	1
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Onchocerca volvulus		0.0183	0.1726	0.3683
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0183	0.1726	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Echinococcus multilocularis	protein tyrosine kinase	0.0183	0.1726	0.1726
Schistosoma mansoni	metabotropic glutamate receptor	0.0139	0.1262	0.279
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	SRC-1	0.0449	0.4524	0.9589
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0322	0.3187	0.673
Leishmania major	protein kinase, putative	0.0183	0.1726	0.9988
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0449	0.4524	0.4612
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0261	0.2553	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0183	0.1726	0.1759
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	receptor type guanylyl cyclase	0.0322	0.3187	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1732	1
Echinococcus multilocularis	integrin linked protein kinase	0.0183	0.1726	0.1726
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	hypothetical protein	0.0183	0.1727	0.3685
Schistosoma mansoni	aldo-keto reductase	0.003	0.0122	0.027
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Brugia malayi	metabotropic glutamate receptor type 2	0.0139	0.1262	0.2481
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Entamoeba histolytica	hypothetical protein	0.0183	0.1732	0.3696
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Echinococcus multilocularis	tyrosine protein kinase csk	0.0183	0.1726	0.1726
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0183	0.1726	0.9988
Schistosoma mansoni	tar DNA-binding protein	0.006	0.043	0.0951
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	tyrosine protein kinase shark	0.0444	0.4478	0.4564
Brugia malayi	hypothetical protein	0.0034	0.0159	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0183	0.1726	0.3815
Brugia malayi	hypothetical protein	0.0183	0.1726	0.349
Brugia malayi	Raf kinase	0.0183	0.1726	0.349
Echinococcus granulosus	expressed conserved protein	0.0261	0.2553	0.2602
Echinococcus multilocularis	activated cdc42 kinase 1	0.0183	0.1726	0.1726
Echinococcus granulosus	aldehyde reductase	0.0022	0.0029	0.003
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0183	0.1726	0.3815
Brugia malayi	SH2 domain containing protein	0.0444	0.4478	0.9478
Onchocerca volvulus		0.0444	0.4478	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.003	0.0122	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.0183	0.1726	0.3815
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0261	0.2553	0.5642
Echinococcus multilocularis	FL cytokine receptor	0.0183	0.1726	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0183	0.1726	0.3607
Toxoplasma gondii	protein kinase domain-containing protein	0.0183	0.1726	0.9988
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0449	0.4524	0.4524
Brugia malayi	hypothetical protein	0.0183	0.1726	0.349
Onchocerca volvulus		0.0322	0.3187	0.7037
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	protein kinase, putative	0.0262	0.2555	0.5585
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0183	0.1726	0.5
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0289	0.2841	0.2896
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0183	0.1726	0.9963
Trichomonas vaginalis	protein kinase atn1, putative	0.0183	0.1726	0.9963
Schistosoma mansoni	glutamate receptor AMPA	0.028	0.2748	0.6074
Echinococcus granulosus	aldo keto reductase	0.003	0.0122	0.0124
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Onchocerca volvulus		0.0167	0.1556	0.3292
Schistosoma mansoni	tyrosine kinase	0.0322	0.3187	0.7044
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0261	0.2553	0.2553
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	hypothetical protein	0.0034	0.0159	0.0352
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0258
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0183	0.1726	0.3815
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1262	0.2616
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0437	0.4399	0.4399
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0183	0.1726	0.1726
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0183	0.1726	0.1726
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0258
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0444	0.4478	0.4564
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	insulin receptor	0.0183	0.1726	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1726	0.3607
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/RYK protein kinase	0.0183	0.1726	0.3607
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0261	0.2553	0.5642
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus granulosus	ephrin type A receptor 4 A	0.0183	0.1726	0.1759
Trypanosoma brucei	Pseudokinase, putative	0.0183	0.1726	0.9988
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Brugia malayi	Tensin	0.0261	0.2553	0.5289
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0183	0.1726	0.1726
Echinococcus multilocularis	SHC transforming protein 3	0.0261	0.2553	0.2553
Schistosoma mansoni	hypothetical protein	0.0261	0.2553	0.5642
Schistosoma mansoni	protein kinase	0.0183	0.1728	0.3819
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.1726	0.9963
Schistosoma mansoni	aldo-keto reductase	0.003	0.0122	0.027
Echinococcus granulosus	c src tyrosine kinase	0.0449	0.4524	0.4612
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0183	0.1726	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Leishmania major	protein kinase, putative	0.0183	0.1728	1
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0271	0.2651	0.2651
Echinococcus granulosus	tyrosine kinase	0.0444	0.4478	0.4564
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0437	0.4399	0.4399
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0139	0.1262	0.1262
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/INSR protein kinase	0.0183	0.1726	0.3607
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	tyrosine kinase	0.0444	0.4478	0.4564
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0261	0.2553	0.5642
Schistosoma mansoni	tar DNA-binding protein	0.006	0.043	0.0951
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0183	0.1726	0.9988
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	Guanylyl cyclase protein 23	0.0322	0.3187	0.6669
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Echinococcus multilocularis	insulin receptor	0.0183	0.1726	0.1726
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0444	0.4478	0.4564
Loa Loa (eye worm)	hypothetical protein	0.0266	0.2599	0.5474
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0183	0.1728	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0183	0.1726	0.9988
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0183	0.1726	0.1726
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0183	0.1726	0.1726
Echinococcus multilocularis	tyrosine protein kinase csk	0.0183	0.1726	0.1726
Schistosoma mansoni	glutamate receptor kainate	0.0298	0.2938	0.6493
Echinococcus multilocularis	protein kinase	0.0183	0.1726	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Onchocerca volvulus	Tyrosine kinase homolog	0.0357	0.3562	0.7897
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0444	0.4478	0.4564
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0437	0.4399	0.4484
Loa Loa (eye worm)	TK/FER protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0261	0.2553	0.2553
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0261	0.2553	0.5289
Schistosoma mansoni	tar DNA-binding protein	0.006	0.043	0.0951
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0183	0.1728	1
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Entamoeba histolytica	cysteine surface protein, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0183	0.1726	0.1759
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Echinococcus multilocularis	aldo keto reductase	0.003	0.0122	0.0122
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0183	0.1726	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	tyrosin kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0183	0.1726	0.3607
Echinococcus multilocularis	NCK adaptor protein	0.0266	0.2599	0.2599
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Schistosoma mansoni	protein kinase	0.0183	0.1728	0.3819
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0183	0.1726	0.9963
Schistosoma mansoni	glutamate receptor kainate	0.0298	0.2938	0.6493
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0266	0.2599	0.2599
Onchocerca volvulus		0.0183	0.1726	0.3683
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Brugia malayi	Tyrosine-protein kinase PR2	0.0183	0.1726	0.349
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0183	0.1726	0.9963
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0183	0.1726	0.1759
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0261	0.2553	0.5581
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0261	0.2553	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0183	0.1726	0.3607
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0449	0.4524	0.4524
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0183	0.1728	1
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	tyrosine protein kinase csk	0.0183	0.1726	0.1726
Brugia malayi	Furin-like cysteine rich region family protein	0.0183	0.1726	0.349
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0261	0.2553	0.2602
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0289	0.2841	0.2841
Echinococcus multilocularis	aldo keto reductase	0.003	0.0122	0.0122
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0449	0.4524	0.4612
Loa Loa (eye worm)	TK/EPH protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Brugia malayi	Sex muscle abnormal protein 5	0.0266	0.2599	0.5391
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0419	0.4209	0.429
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	hypothetical protein	0.0138	0.1254	0.2463
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	RNA binding protein	0.006	0.043	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0258
Leishmania major	extracellular receptor, putative	0.0139	0.1262	0.7099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0261	0.2553	0.5374
Plasmodium falciparum	protein kinase, putative	0.0183	0.1728	1
Brugia malayi	SH2 domain containing protein	0.0444	0.4478	0.9478
Echinococcus granulosus	integrin linked protein kinase	0.0183	0.1726	0.1759
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0322	0.3187	0.673
Brugia malayi	Tyrosine-protein kinase abl-1	0.0449	0.4524	0.9579
Schistosoma mansoni	protein kinase	0.0183	0.1728	0.3819
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0183	0.1728	0.1728
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Schistosoma mansoni	tyrosine kinase	0.0194	0.1845	0.4078
Echinococcus multilocularis	SH2 domain containing protein 7	0.0261	0.2553	0.2553
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0183	0.1726	0.5
Echinococcus granulosus	twitchin	0.0019	0.0002	0.0002
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Echinococcus granulosus	NCK adaptor protein	0.0266	0.2599	0.265
Brugia malayi	Protein kinase domain containing protein	0.0444	0.4478	0.9478
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Loa Loa (eye worm)	TK protein kinase	0.019	0.1807	0.3779
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	serine/threonine protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	glutamate receptor 1	0.028	0.2748	0.5792
Onchocerca volvulus		0.0261	0.2553	0.5581
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.003	0.0122	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	AGC family protein kinase	0.0183	0.1726	0.9963
Echinococcus granulosus	tyrosine protein kinase csk	0.0183	0.1726	0.1759
Loa Loa (eye worm)	TAR-binding protein	0.006	0.043	0.0838
Schistosoma mansoni	protein kinase	0.0322	0.3187	0.7044
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0183	0.1726	0.3815
Entamoeba histolytica	serine/threonine kinase, putative	0.0183	0.1726	0.3683
Echinococcus multilocularis	SH2 motif	0.0261	0.2553	0.2553
Brugia malayi	SH2 domain containing protein	0.0261	0.2553	0.5289
Brugia malayi	Protein kinase domain containing protein	0.0444	0.4478	0.9478
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0419	0.4209	0.4209
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Echinococcus multilocularis	epidermal growth factor receptor	0.0183	0.1726	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Brugia malayi	C-terminal src kinase protein 1	0.0183	0.1726	0.349
Trypanosoma brucei	protein kinase, putative	0.0183	0.1728	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0449	0.4524	0.4612
Entamoeba histolytica	tyrosine kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK/DDR protein kinase	0.0183	0.1726	0.3607
Schistosoma mansoni	pol-related	0.003	0.0122	0.027
Brugia malayi	TAR-binding protein	0.006	0.043	0.0671
Onchocerca volvulus		0.0261	0.2553	0.5581
Echinococcus granulosus	tyrosine protein kinase csk	0.0183	0.1726	0.1759
Echinococcus multilocularis	SH2 motif	0.0261	0.2553	0.2553
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0183	0.1726	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0261	0.2553	0.2602
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0183	0.1726	0.1759
Brugia malayi	hypothetical protein	0.0139	0.1262	0.2481
Brugia malayi	Variant SH3 domain containing protein	0.0261	0.2553	0.5289
Echinococcus granulosus	tyrosine protein kinase Srms	0.0444	0.4478	0.4564
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Onchocerca volvulus		0.0261	0.2553	0.5581
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	glutamate NMDA receptor subunit	0.028	0.2748	0.2801
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0183	0.1726	0.1759
Echinococcus multilocularis	aldehyde reductase	0.0022	0.0029	0.0029
Entamoeba histolytica	protein kinase domain containing protein	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Loa Loa (eye worm)	TK protein kinase	0.0183	0.1726	0.3607
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0183	0.1726	0.3607
Echinococcus granulosus	glutamate receptor 2	0.0148	0.1359	0.1385
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.068	0.696	1
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Schistosoma mansoni	tensin	0.0261	0.2553	0.5642
Entamoeba histolytica	tyrosin kinase, putative	0.0183	0.1726	0.3683
Echinococcus granulosus	tensin	0.0261	0.2553	0.2602
Echinococcus granulosus	tyrosine protein kinase HCK	0.0183	0.1726	0.1759
Schistosoma mansoni	growth factor receptor-bound protein	0.0266	0.2599	0.5745
Schistosoma mansoni	tyrosine kinase	0.0183	0.1726	0.3815
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0449	0.4524	0.4524
Entamoeba histolytica	hypothetical protein	0.0183	0.1726	0.3683
Schistosoma mansoni	tyrosine kinase	0.0449	0.4524	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0437	0.4399	0.4399
Echinococcus granulosus	tyrosine protein kinase Blk	0.0444	0.4478	0.4564
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0183	0.1726	0.1726
Schistosoma mansoni	tar DNA-binding protein	0.006	0.043	0.0951
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0183	0.1726	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	TK/ALK protein kinase	0.0467	0.4717	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2553	0.5374
Schistosoma mansoni	ATP-binding cassette transporter	0.028	0.2748	0.6074
Giardia lamblia	Kinase, NEK	0.0183	0.1726	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1254	0.2598
Echinococcus granulosus	tar DNA binding protein	0.006	0.043	0.0439
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0183	0.1726	0.1759
Schistosoma mansoni	nck2/grb4	0.0266	0.2599	0.5745
Onchocerca volvulus		0.0261	0.2553	0.5581
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	glutamate receptor 2	0.0419	0.4209	0.4209
Entamoeba histolytica	protein kinase, putative	0.0183	0.1726	0.3683
Schistosoma mansoni	tensin	0.0261	0.2553	0.5642
Echinococcus multilocularis	tyrosine kinase	0.0444	0.4478	0.4478
Schistosoma mansoni	metabotropic glutamate receptor	0.0139	0.1262	0.279
Brugia malayi	Protein kinase domain containing protein	0.0183	0.1726	0.349
Schistosoma mansoni	suppressor of cytokine signaling	0.0261	0.2553	0.5642
Trichomonas vaginalis	TKL family protein kinase	0.0183	0.1726	0.9963
Echinococcus multilocularis	tar DNA binding protein	0.006	0.043	0.043
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0449	0.4524	0.4612
Schistosoma mansoni	tar DNA-binding protein	0.006	0.043	0.0951
Schistosoma mansoni	hypothetical protein	0.0261	0.2553	0.5642
Loa Loa (eye worm)	STAT protein	0.0261	0.2553	0.5374
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0183	0.1726	0.3815
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0183	0.1726	0.3683
Loa Loa (eye worm)	oxidoreductase	0.003	0.0122	0.0178
Schistosoma mansoni	protein kinase	0.0183	0.1726	0.3815
Loa Loa (eye worm)	TK/FER protein kinase	0.0444	0.4478	0.9489

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.007 uM	Inhibition of human LRRK2 (1885 to 2132) using 5-Fluo-Ahx-RLGRDKYKTLRQIRQGNTK-OH as substrate after 60 mins by fluorescence assay	ChEMBL.	23768909
IC50 (binding)	= 0.016 uM	Inhibition of KDR (unknown origin)	ChEMBL.	23768909
IC50 (binding)	= 0.075 uM	Inhibition of RET (unknown origin)	ChEMBL.	23768909
IC50 (binding)	= 0.39 uM	Inhibition of LCK (unknown origin)	ChEMBL.	23768909
IC50 (binding)	= 0.54 uM	Inhibition of PDGFRa (unknown origin)	ChEMBL.	23768909
IC50 (binding)	= 1.4 uM	Inhibition of ALK (unknown origin)	ChEMBL.	23768909

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2403368

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1776874