Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0.0923 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0923 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0923 | 0.0923 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0923 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.0923 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0022 | 0.0923 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0923 | 0.0923 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0022 | 0.0923 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0923 | 0.0923 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0.0923 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0022 | 0.0923 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0022 | 0.0923 | 0.0923 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0923 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0022 | 0.0923 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0022 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0022 | 0.0923 | 0.5 |
Brugia malayi | FXNA | 0.0022 | 0.0923 | 0.0923 |
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0.0923 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0022 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0923 | 0.0923 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0022 | 0.0923 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0022 | 0.0923 | 0.0923 |
Brugia malayi | nicalin | 0.0022 | 0.0923 | 0.0923 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0923 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0923 | 0.0923 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0022 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0022 | 0.0923 | 0.0923 |
Brugia malayi | leucyl aminopeptidase | 0.0022 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0923 | 0.0923 |
Schistosoma mansoni | nicalin (M28 family) | 0.0022 | 0.0923 | 0.0923 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0923 | 0.0923 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 381 nM | Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis | ChEMBL. | 23643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.