Detailed information for compound 178042

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.331 | Formula: C14H18N6O4
  • H donors: 4 H acceptors: 6 LogP: -1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H]1O[C@@H]([C@@H]([C@H]1O)O)n1cnc2c1ncnc2N)NC1CCC1
  • InChi: 1S/C14H18N6O4/c15-11-7-12(17-4-16-11)20(5-18-7)14-9(22)8(21)10(24-14)13(23)19-6-2-1-3-6/h4-6,8-10,14,21-22H,1-3H2,(H,19,23)(H2,15,16,17)/t8?,9-,10-,14+/m0/s1
  • InChiKey: CGYRWWMWNACLSU-RVEKLTCUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0213 0.0287 0.7388
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0431 0.0624 0.0624
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0023 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0009 0.0007
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0431 0.0624 0.0622
Schistosoma mansoni hypothetical protein 0.0038 0.0017 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0033 0.0032
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0011 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0023 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0052 0.1334
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0023 0.0023
Echinococcus granulosus tissue type plasminogen activator 0.006 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0195 0.0194
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0041 0.2699
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Schistosoma mansoni coup transcription factor 0.0042 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0033 0.0032
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0046 0.0029 0.1943
Schistosoma mansoni lipoxygenase 0.0086 0.0091 0.0089
Schistosoma mansoni hypothetical protein 0.0049 0.0033 0.0032
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0011 0.0274
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0046 0.0029 0.1943
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.305
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Brugia malayi nuclear hormone receptor 0.0042 0.0023 0.0021
Toxoplasma gondii hypothetical protein 0.0107 0.0124 0.0123
Toxoplasma gondii hypothetical protein 0.0039 0.0019 0.0017
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0325 0.0461 0.0461
Brugia malayi MH2 domain containing protein 0.0126 0.0153 0.0151
Schistosoma mansoni hypothetical protein 0.0105 0.012 0.0119
Brugia malayi Endoplasmin precursor 0.0034 0.0011 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0144 0.0181 0.0181
Plasmodium vivax phosphodiesterase gamma, putative 0.0105 0.0121 0.3089
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0935 0.1404 0.1402
Onchocerca volvulus 0.0042 0.0023 0.1078
Toxoplasma gondii kringle domain-containing protein 0.006 0.0052 0.005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Loa Loa (eye worm) hypothetical protein 0.0431 0.0624 0.0623
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0002 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0655 0.0971 0.0971
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0019 0.0439
Toxoplasma gondii Acetyl-coenzyme A transporter, putative 0.6499 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0105 0.0121 0.0121
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0174 0.0227 0.5837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0032 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0049 0.0033 0.0032
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0278 0.0388 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0009 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Plasmodium vivax endoplasmin, putative 0.0034 0.0011 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0023 0.0021
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0011 0.0274
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0105 0.0121 0.3119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0023 0.0023
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0023 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0023 0.0021
Plasmodium falciparum phosphodiesterase delta, putative 0.0105 0.0121 0.0119
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0009 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0023 0.0021
Schistosoma mansoni hypothetical protein 0.0049 0.0033 0.0032
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0278 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.0181 0.018
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0148 0.0148
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni hypothetical protein 0.0349 0.0497 0.0495
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0023 0.0021
Echinococcus granulosus lamin 0.0028 0.0002 0.0002
Leishmania major trypanothione reductase 0.0049 0.0034 0.0884
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0023 0.1078
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0151 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0023 0.0023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0009 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0023 0.0022
Schistosoma mansoni heat shock protein 0.0034 0.0011 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0023 0.0021
Echinococcus granulosus neuropeptide s receptor 0.0968 0.1455 0.1455
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0127 0.0155 0.0154
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0011 0.0231
Echinococcus granulosus microtubule associated protein 2 0.1419 0.2152 0.2152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0009 0.0224
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0213 0.0287 0.0285
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0004 0.0004
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0144 0.0181 0.018
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Schistosoma mansoni solute carrier family 33 (acetyl-CoA transporter 0.6499 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0153 0.0152
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0011 0.0009
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0105 0.0121 0.0121
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0023 0.1078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0023 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni hypothetical protein 0.006 0.0052 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0033 0.0033
Echinococcus multilocularis musashi 0.0028 0.0002 0.0002
Echinococcus granulosus importin subunit beta 1 0.0029 0.0004 0.0004
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0278 0.0388 1
Schistosoma mansoni hypothetical protein 0.0049 0.0033 0.0032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni lipoxygenase 0.0122 0.0148 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0023 0.0021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0023 0.0021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0084 0.5565
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0655 0.0971 0.097
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0011 0.0274
Brugia malayi Importin beta-1 subunit 0.0029 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0124 0.4331
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0144 0.0181 0.018
Echinococcus multilocularis heat shock protein 0.0034 0.0011 0.0011
Schistosoma mansoni heat shock protein 0.0034 0.0011 0.0009
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0041 0.2699
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0121 0.305
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0023 0.0021
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0132 0.872
Schistosoma mansoni solute carrier family 33 (acetyl-CoA transporter 0.2416 0.3691 0.369
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Onchocerca volvulus Huntingtin homolog 0.0127 0.0155 0.7879
Giardia lamblia hypothetical protein 0.0105 0.0121 0.1941
Loa Loa (eye worm) endoplasmin 0.0034 0.0011 0.001
Plasmodium falciparum acetyl-CoA transporter, putative 0.6499 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0153 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0039 0.0994
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0009 0.0181
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0195 0.0194
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0213 0.0287 0.7388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.003
Brugia malayi heat shock protein 90 0.0034 0.0011 0.0009
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0105 0.0121 0.3119
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0011 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0039 0.0037
Leishmania major hypothetical protein, conserved 0.0052 0.0039 0.0994
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0033 0.0032
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0105 0.0121 0.0119
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0213 0.0287 0.0287
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0151 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0132 0.872
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0144 0.0181 0.6321
Brugia malayi Kringle domain containing protein 0.006 0.0052 0.005
Schistosoma mansoni endoplasmin 0.0034 0.0011 0.0009
Echinococcus granulosus intermediate filament protein 0.0028 0.0002 0.0002
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.0052 0.0051
Brugia malayi Protein kinase domain containing protein 0.006 0.0052 0.005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0023 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0023 0.0021
Schistosoma mansoni endoplasmin 0.0034 0.0011 0.0009
Brugia malayi hypothetical protein 0.0038 0.0017 0.0015
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0132 0.872
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0023 0.0021
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0023 0.0023
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Echinococcus granulosus snurportin 1 0.0314 0.0443 0.0443
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.3089
Echinococcus multilocularis neuropeptide s receptor 0.0968 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0527 0.0773 0.0772
Brugia malayi photoreceptor-specific nuclear receptor 0.0527 0.0773 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.003
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0144 0.0181 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0023 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0032 0.0031
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0002 0.0113
Toxoplasma gondii GAF domain-containing protein 0.0039 0.0019 0.0017
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0174 0.0227 0.7901
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0039 0.0954
Brugia malayi isocitrate dehydrogenase 0.0032 0.0009 0.0007
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0213 0.0287 0.7362
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0011 0.0274
Loa Loa (eye worm) PDE1B protein 0.0655 0.0971 0.097
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0009 0.0009
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0084 0.0082
Echinococcus multilocularis GPCR, family 2 0.0049 0.0033 0.0033
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0023 0.0022
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0033 0.0033
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0019 0.2226
Echinococcus granulosus geminin 0.0349 0.0497 0.0497
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0009 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0004 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Loa Loa (eye worm) hypothetical protein 0.6499 1 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0325 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0081 0.0084 0.0083
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0023 0.0022
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0023 0.0023
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.4222
Brugia malayi RNA, U transporter 1 0.0084 0.0088 0.0086
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0431 0.0624 0.0624
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0019 0.2226
Echinococcus multilocularis tissue type plasminogen activator 0.006 0.0052 0.0052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0023 0.0023
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0011 0.0176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0213 0.0287 0.0287
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0023 0.1078
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0431 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.083 0.1241 0.124
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0121 0.4222
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0213 0.0287 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0132 0.872
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0105 0.0121 0.0121
Plasmodium falciparum cysteine repeat modular protein 1 0.006 0.0052 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0278 0.0388 0.0387
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0154 0.0196 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.1419 0.2152 0.2152
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0278 0.0388 0.0387
Schistosoma mansoni solute carrier family 33 (acetyl-CoA transporter 0.6499 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0121 0.4222
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0023 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0039 0.0903
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.0119
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0153 0.0195 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0034 0.0033
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.4222
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0124 0.4331
Onchocerca volvulus Huntingtin homolog 0.0127 0.0155 0.7879
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 0.0082
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0019 0.1239
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0105 0.0121 0.0121
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0278 0.0388 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0431 0.0624 0.0624
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0144 0.0181 0.6321
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0019 0.0651
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0968 0.1455 0.1455
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Brugia malayi ecdysteroid receptor 0.0042 0.0023 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0032 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0132 0.872
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0325 0.0461 0.046
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0039 0.0037
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0041 0.0041
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Leishmania major hypothetical protein, conserved 0.006 0.0052 0.1334
Brugia malayi steroid hormone receptor 0.0042 0.0023 0.0021
Brugia malayi Thioredoxin reductase 0.0049 0.0034 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0023 0.0021
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0009 0.0007
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0195 0.0194
Plasmodium falciparum glutathione reductase 0.0049 0.0034 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0431 0.0624 0.0622
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni hypothetical protein 0.0349 0.0497 0.0495
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0213 0.0287 0.7388
Plasmodium falciparum heat shock protein 90 0.0034 0.0011 0.0009
Echinococcus multilocularis heat shock protein 90 0.0034 0.0011 0.0011
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0213 0.0287 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0105 0.0121 0.0119
Echinococcus granulosus neuropeptide receptor A26 0.0968 0.1455 0.1455
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0023 0.0022
Echinococcus multilocularis lamin 0.0028 0.0002 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0041 0.2699
Brugia malayi hypothetical protein 0.0154 0.0196 0.0195
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0034 0.2276
Brugia malayi Probable ClpP-like protease 0.0081 0.0084 0.0082
Brugia malayi hypothetical protein 0.0052 0.0039 0.0037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0023 0.0023
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0034 0.0844
Plasmodium falciparum thioredoxin reductase 0.0049 0.0034 0.0033
Schistosoma mansoni importin beta-1 0.0029 0.0004 0.0002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 0.5
Giardia lamblia Hypothetical protein 0.0105 0.0121 0.1941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0023 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0287 1
Echinococcus granulosus solute carrier family 33 0.6499 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0023 0.0023
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0084 0.2127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0017 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0105 0.0121 0.012
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0105 0.0121 0.0119
Leishmania major cAMP-specific phosphodiesterase, putative 0.0105 0.0121 0.3119
Schistosoma mansoni hypothetical protein 0.0314 0.0443 0.0441
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0011 0.0176
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0002 0.0202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0032 0.0032
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.3089
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.4222
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0023 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.305
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0023 0.0023
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0105 0.0121 0.305
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Echinococcus granulosus heat shock protein 90 0.0034 0.0011 0.0011
Echinococcus multilocularis snurportin 1 0.0314 0.0443 0.0443
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0023 0.0022
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0002 0.0001
Toxoplasma gondii thioredoxin reductase 0.0049 0.0034 0.0033
Plasmodium falciparum phosphodiesterase gamma, putative 0.0105 0.0121 0.0119
Brugia malayi glutathione reductase 0.0049 0.0034 0.0033
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0431 0.0624 1
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Schistosoma mansoni microtubule-associated protein tau 0.1419 0.2152 0.215
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0009 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Onchocerca volvulus 0.006 0.0052 0.2573
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0174 0.0227 0.7901
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0655 0.0971 0.0971
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0034 0.0034
Toxoplasma gondii hypothetical protein 0.0039 0.0019 0.0017
Echinococcus granulosus lamin dm0 0.0028 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0132 0.872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0032 0.0032
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0011 0.037
Trypanosoma brucei trypanothione reductase 0.0049 0.0034 0.0793
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Echinococcus granulosus heat shock protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0051
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0023 0.0023
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0935 0.1404 0.1403
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0105 0.0121 0.0119
Leishmania major hypothetical protein, conserved 0.0105 0.0121 0.3119
Plasmodium vivax cysteine repeat modular protein 1, putative 0.006 0.0052 0.1296
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0009 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0023 0.0021
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Leishmania major heat shock protein 83-1 0.0034 0.0011 0.0274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0009 0.0009
Plasmodium vivax glutathione reductase, putative 0.0049 0.0034 0.0844
Echinococcus granulosus GPCR family 2 0.0049 0.0033 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0032 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0148 0.0148
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0039 0.0994
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0017 0.0015
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0144 0.0181 0.6321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0023 0.0021
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0213 0.0287 0.7362
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0105 0.0121 0.4222
Brugia malayi nuclear receptor NHR-88 0.0042 0.0023 0.0021
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0278 0.0388 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Onchocerca volvulus 0.0154 0.0196 1
Echinococcus multilocularis solute carrier family 33 0.6499 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.0443 0.0442
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0023 0.0021
Leishmania major hypothetical protein, conserved 0.0105 0.0121 0.3119
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0009 0.0009
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0105 0.0121 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0033 0.0033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0017 0.0017
Plasmodium falciparum importin beta, putative 0.0029 0.0004 0.0002
Brugia malayi Protein C21B10.09 in chromosome II 0.6499 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0655 0.0971 0.097
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0105 0.0121 0.012
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0084 0.0082
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0034 0.0034
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0011 0.0274
Echinococcus multilocularis lamin dm0 0.0028 0.0002 0.0002
Brugia malayi hypothetical protein 0.0127 0.0155 0.0153
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0023 0.0023
Trypanosoma brucei heat shock protein, putative 0.0034 0.0011 0.0176
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0105 0.0121 0.0119
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0105 0.0121 0.4222
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0124 0.4331
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0033 0.0032
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0213 0.0287 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.012 0.0119
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0084 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0023 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0151 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0046 0.0029 0.3491
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.0038
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0278 0.0388 0.0388
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0144 0.0181 0.018
Plasmodium vivax importin-beta 2, putative 0.0029 0.0004 0.0056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0151 1
Mycobacterium tuberculosis Probable reductase 0.0112 0.0132 0.872
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0009 0.0576
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0034 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0121 0.3119
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0023 0.0023
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0011 0.017
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0084 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0033 0.0033
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0213 0.0287 1
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0023 0.0023
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 1
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0127 0.0155 0.0154
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0325 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0023 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 0.0121 0.0119
Echinococcus multilocularis geminin 0.0349 0.0497 0.0497
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.012 0.0119
Loa Loa (eye worm) glutathione reductase 0.0049 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0023 0.0021
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0278 0.0388 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0023 0.0021
Brugia malayi hypothetical protein 0.0033 0.001 0.0008
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0011 0.0176

Activities

Activity type Activity value Assay description Source Reference
BP (functional) = 45 mmHg Tested for the percent increase in aortic blood pressure (BP) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 48 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of heart rate in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 90 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of oxygen partial pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 90 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of blood pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
HR (functional) = 24 % Tested for the percent increase in heart rate (HR) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
LD50 (ADMET) = 2 mg kg-1 Lethal dose in mice after intraperitoneal administration ChEMBL. 7365748
LD50 (ADMET) = 5 mg kg-1 Lethal dose in mice after peroral administration ChEMBL. 7365748
PO2 (functional) = 79 % Tested for percent increase in coronary sinus partial pressure of oxygen (PO2) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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