TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 261.075 | Formula: C14H14BF2NO
H donors: 1 H acceptors: 0 LogP: 3.37 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)[B-]1(OCC[NH2+]1)c1ccc(cc1)F
InChi: 1S/C14H14BF2NO/c16-13-5-1-11(2-6-13)15(18-9-10-19-15)12-3-7-14(17)8-4-12/h1-8H,9-10,18H2
InChiKey: HIAUSIXEXUGJQR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ORAI calcium release-activated calcium modulator 3	Starlite/ChEMBL	References
Homo sapiens	ORAI calcium release-activated calcium modulator 2	Starlite/ChEMBL	References
Homo sapiens	ORAI calcium release-activated calcium modulator 1		References
Homo sapiens	transient receptor potential cation channel, subfamily V, member 6	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	calcium release activated calcium channel	Get druggable targets OG5_130743	All targets in OG5_130743
Brugia malayi	hypothetical protein	Get druggable targets OG5_130743	All targets in OG5_130743
Schistosoma mansoni	Protein orai-1	Get druggable targets OG5_130743	All targets in OG5_130743
Brugia malayi	olfactory channel protein osm-9	Get druggable targets OG5_131423	All targets in OG5_131423
Schistosoma japonicum	IPR012446,Protein of unknown function DUF1650,domain-containing	Get druggable targets OG5_130743	All targets in OG5_130743
Schistosoma mansoni	Protein orai-1	Get druggable targets OG5_130743	All targets in OG5_130743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131423	All targets in OG5_131423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130743	All targets in OG5_130743
Echinococcus multilocularis	calcium release activated calcium channel	Get druggable targets OG5_130743	All targets in OG5_130743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	TRP channel protein nanchung	transient receptor potential cation channel, subfamily V, member 6	725 aa	595 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0334	0.2025	0.2025
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0065	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	Inositol-1	0.003	0.0115	0.0115
Onchocerca volvulus		0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.0332	0.0332
Echinococcus multilocularis	transfer RNA-Lys	0.003	0.011	0.011
Onchocerca volvulus		0.0065	0.0332	1
Brugia malayi	hypoxia-induced factor 1	0.0124	0.0703	0.0703
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	bHLH-PAS transcription factor	0.003	0.011	0.011
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.0332	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.0332	0.0332
Leishmania major	tyrosine specific protein phosphatase, putative	0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1604	1	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.003	0.0115	0.347
Schistosoma mansoni	Protein orai-1	0.1323	0.8236	0.8236
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	single-minded	0.004	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0511	0.0511
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1604	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	hypothetical protein	0.1323	0.8236	0.8236
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0065	0.0332	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase 1	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0065	0.0332	0.0332
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0065	0.0332	0.0332
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0334	0.2025	0.2025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	inositol monophosphatase	0.003	0.0115	0.0115
Schistosoma mansoni	tyrosine kinase	0.0012	0.0001	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0334	0.2025	0.2025
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	olfactory channel protein osm-9	0.0093	0.0511	0.0511
Loa Loa (eye worm)	hypothetical protein	0.1323	0.8236	0.8236
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0065	0.0332	0.0332
Onchocerca volvulus	4.1 G protein, putative homolog	0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0334	0.2025	0.2025
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0027	0.0095	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus granulosus	calcium release activated calcium channel	0.1323	0.8236	0.8236
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.0332	0.0332
Brugia malayi	PAS domain containing protein	0.004	0.0176	0.0176
Onchocerca volvulus		0.0065	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.003	0.0115	0.5
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0065	0.0332	0.0332
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Giardia lamblia	Protein tyrosine phosphatase	0.0065	0.0332	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0334	0.2025	0.2025
Brugia malayi	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.003	0.0115	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0334	0.2025	0.2025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0334	0.2025	0.2025
Echinococcus multilocularis	inositol monophosphatase 1	0.003	0.0115	0.0115
Schistosoma mansoni	inositol monophosphatase	0.003	0.0115	0.0115
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0065	0.0332	0.0332
Onchocerca volvulus		0.003	0.011	0.3325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0124	0.0703	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0065	0.0332	0.0332
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.0332	0.0332
Echinococcus multilocularis	calcium release activated calcium channel	0.1323	0.8236	0.8236
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0065	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Onchocerca volvulus		0.0065	0.0332	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.0332	0.0332
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0065	0.0332	1
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0065	0.0332	0.0332
Echinococcus granulosus	single minded 2	0.003	0.011	0.011
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0768	0.0768
Schistosoma mansoni	Protein orai-1	0.1323	0.8236	0.8236
Trichomonas vaginalis	pten, drome, putative	0.0065	0.0332	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1604	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0065	0.0332	0.0332
Echinococcus multilocularis	tyrosine protein kinase shark	0.0012	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0065	0.0332	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.004	0.0176	0.0176
Brugia malayi	hypothetical protein	0.0065	0.0332	0.0332
Echinococcus granulosus	inositol monophosphatase 1	0.003	0.0115	0.0115
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.003	0.0115	1
Brugia malayi	hypothetical protein	0.0134	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0027	0.0095	0.5
Onchocerca volvulus		0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.0332	0.0332
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0065	0.0332	0.0332
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0065	0.0332	0.0332
Brugia malayi	hypothetical protein	0.0065	0.0332	0.0332
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.0332	0.0332
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.0332	1
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis		0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Loa Loa (eye worm)	inositol-1	0.003	0.0115	0.0115
Brugia malayi	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.0332	0.0332
Echinococcus multilocularis	hypothetical protein	0.0065	0.0332	0.0332
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.0332	1
Onchocerca volvulus		0.0065	0.0332	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0012	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0332	0.0332
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.0332	0.0332
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1604	1	1
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0065	0.0332	0.0332

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.9 uM	Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin	ChEMBL.	23602525
IC50 (binding)	= 9 uM	Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin	ChEMBL.	23602525
IC50 (binding)	= 14.2 uM	Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay	ChEMBL.	23602525
IC50 (binding)	= 17 uM	Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay	ChEMBL.	23602525

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2386174

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1782569