Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0119 | 0.0068 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0119 | 0.0068 |
Brugia malayi | PXA domain containing protein | 0.0105 | 0.0799 | 0.0752 |
Schistosoma mansoni | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0752 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0838 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0119 | 0.5 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0157 | 0.1311 | 0.141 |
Schistosoma mansoni | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0752 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0105 | 0.0799 | 0.0838 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0105 | 0.0799 | 0.0838 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.0552 | 0.0503 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0105 | 0.0799 | 0.0838 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Echinococcus granulosus | alkaline phosphatase | 0.0157 | 0.1311 | 0.141 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0119 | 0.5 |
Loa Loa (eye worm) | RGS-3 protein | 0.0105 | 0.0799 | 0.0752 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0105 | 0.0799 | 0.0838 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0105 | 0.0799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0119 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0575 | 0.0527 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0944 | 0.898 | 0.8975 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0119 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0752 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0157 | 0.1311 | 0.141 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0119 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0119 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0105 | 0.0799 | 0.0752 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0799 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0157 | 0.1311 | 0.141 |
Brugia malayi | PXA domain containing protein | 0.0105 | 0.0799 | 0.0752 |
Echinococcus granulosus | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0838 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1049 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0105 | 0.0799 | 0.0838 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0944 | 0.898 | 0.8975 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0824 | 0.0777 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1049 | 1 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0944 | 0.898 | 0.8975 |
Echinococcus multilocularis | snurportin 1 | 0.0297 | 0.2678 | 0.2941 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0119 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0944 | 0.898 | 1 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0944 | 0.898 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0799 | 1 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0107 | 0.0824 | 0.0777 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0838 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0119 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0119 | 0.1486 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0105 | 0.0799 | 0.0838 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0119 | 0.1486 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2678 | 0.264 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0157 | 0.1311 | 0.141 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0119 | 0.0068 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0297 | 0.2678 | 0.264 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0824 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0051 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0105 | 0.0799 | 0.0838 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0119 | 0.0068 |
Schistosoma mansoni | alkaline phosphatase | 0.0157 | 0.1311 | 0.1266 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0119 | 0.0068 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0105 | 0.0799 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Schistosoma mansoni | alkaline phosphatase | 0.0157 | 0.1311 | 0.1266 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0107 | 0.0824 | 0.0865 |
Schistosoma mansoni | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0752 |
Onchocerca volvulus | 0.0035 | 0.0119 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Echinococcus multilocularis | alkaline phosphatase | 0.0157 | 0.1311 | 0.141 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0119 | 0.0076 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0799 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Echinococcus granulosus | snurportin 1 | 0.0297 | 0.2678 | 0.2941 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0105 | 0.0799 | 0.0752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0105 | 0.0799 | 0.0752 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0105 | 0.0799 | 0.0838 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0105 | 0.0799 | 0.0752 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0105 | 0.0799 | 0.0752 |
Onchocerca volvulus | 0.0035 | 0.0119 | 0.5 | |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0105 | 0.0799 | 0.0838 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0119 | 0.1486 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0119 | 0.1486 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0119 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0799 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0105 | 0.0799 | 0.0838 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0119 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0107 | 0.0824 | 0.0865 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0105 | 0.0799 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0119 | 0.0068 |
Echinococcus granulosus | axis inhibition protein axin | 0.0105 | 0.0799 | 0.0838 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0119 | 0.0068 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.1945 | 1 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0105 | 0.0799 | 0.0838 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0157 | 0.1311 | 0.141 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0119 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0119 | 0.0068 |
Schistosoma mansoni | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0752 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0105 | 0.0799 | 0.0752 |
Schistosoma mansoni | regulator of G protein signaling | 0.0105 | 0.0799 | 0.0752 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0119 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0105 | 0.0799 | 0.0752 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0119 | 0.0068 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0119 | 1 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0105 | 0.0799 | 0.0838 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0105 | 0.0799 | 0.0752 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0119 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0119 | 0.1486 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0105 | 0.0799 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0157 | 0.1311 | 0.141 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0105 | 0.0799 | 0.0752 |
Onchocerca volvulus | 0.0035 | 0.0119 | 0.5 | |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0105 | 0.0799 | 0.0838 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0119 | 0.1486 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0799 | 0.0752 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human SRC at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human MELK at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human NUAK1 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human YES1 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human HER4 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human BTK at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human LCK at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human EPHA2 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human CHK1 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human RSK1 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human MST2 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human GCK at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human EPHB3 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human PRK2 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human PIM1 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human IRAK4 at 1 uM | ChEMBL. | 24035097 | |
Inhibition (binding) | Inhibition of human CSK at 1 uM | ChEMBL. | 24035097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.