Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0175 | 0.0907 | 0.0896 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.0565 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0175 | 0.0907 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0186 | 0.0175 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.0639 | 1 |
Echinococcus granulosus | expressed protein | 0.0175 | 0.0907 | 0.1008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0165 | 0.0165 |
Schistosoma mansoni | regulator of G protein signaling | 0.0175 | 0.0907 | 0.0907 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0012 | 0.0013 |
Echinococcus granulosus | tumor protein p63 | 0.0341 | 0.1864 | 0.2073 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0175 | 0.0907 | 0.1008 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0191 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.0565 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0191 | 0.0191 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0012 | 0.0012 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0165 | 0.0183 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0175 | 0.0907 | 0.0907 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0165 | 0.0183 |
Onchocerca volvulus | 0.005 | 0.0186 | 1 | |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0175 | 0.0907 | 0.0907 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0175 | 0.0907 | 0.1008 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0012 | 0.0013 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0056 | 0.0062 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0012 | 0.0013 |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 0.1864 | 0.2073 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0175 | 0.0907 | 0.1008 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0191 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1577 | 0.8992 | 0.8992 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0179 | 0.0931 | 0.1035 |
Echinococcus granulosus | axis inhibition protein axin | 0.0175 | 0.0907 | 0.1008 |
Entamoeba histolytica | hypothetical protein | 0.0175 | 0.0907 | 0.5 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0175 | 0.0907 | 0.1008 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0191 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0191 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0056 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0053 | 0.0041 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0175 | 0.0907 | 0.0907 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1577 | 0.8992 | 1 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0175 | 0.0907 | 0.0907 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | RUN | 0.002 | 0.0012 | 0.0013 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0175 | 0.0907 | 0.1008 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0175 | 0.0907 | 0.1008 |
Brugia malayi | hypothetical protein | 0.002 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1751 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0179 | 0.0931 | 0.092 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0056 | 0.0062 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0056 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Schistosoma mansoni | axis inhibition protein axin | 0.0175 | 0.0907 | 0.0907 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0907 | 0.0907 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0012 | 0.0623 |
Schistosoma mansoni | regulator of G protein signaling | 0.0175 | 0.0907 | 0.0907 |
Onchocerca volvulus | 0.0027 | 0.0056 | 0.2509 | |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0175 | 0.0907 | 0.1008 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0191 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0189 | 0.0189 |
Schistosoma mansoni | axis inhibition protein axin | 0.0175 | 0.0907 | 0.0907 |
Schistosoma mansoni | lipoxygenase | 0.0055 | 0.0215 | 0.0215 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0012 | 0.0013 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.0639 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0175 | 0.0907 | 0.0907 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0175 | 0.0907 | 0.0907 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0191 | 0.0179 |
Treponema pallidum | NADH oxidase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1577 | 0.8992 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0012 | 0.0013 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0191 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0186 | 0.0186 |
Brugia malayi | PXA domain containing protein | 0.0175 | 0.0907 | 0.0907 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0179 | 0.0931 | 0.1035 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.0639 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0165 | 0.0165 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0165 | 0.0183 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0056 | 0.0044 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0175 | 0.0907 | 0.0907 |
Schistosoma mansoni | regulator of G protein signaling | 0.0175 | 0.0907 | 0.0907 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0175 | 0.0907 | 0.1008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1751 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0012 | 0.0012 |
Echinococcus granulosus | axis inhibition protein axin | 0.0175 | 0.0907 | 0.1008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0189 | 0.0189 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.0931 | 0.0931 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0175 | 0.0907 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0056 | 0.0044 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0012 | 0.0623 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0175 | 0.0907 | 0.1008 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.0639 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0175 | 0.0907 | 0.1008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0165 | 0.0165 |
Entamoeba histolytica | hypothetical protein | 0.0175 | 0.0907 | 0.5 |
Echinococcus multilocularis | RUN | 0.002 | 0.0012 | 0.0013 |
Schistosoma mansoni | lipoxygenase | 0.002 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.0565 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0191 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0055 | 0.0215 | 0.0239 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0012 | 0.0012 |
Schistosoma mansoni | lamin | 0.0027 | 0.0056 | 0.0056 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0165 | 0.0165 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0175 | 0.0907 | 0.1008 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0175 | 0.0907 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0097 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Schistosoma mansoni | regulator of G protein signaling | 0.0175 | 0.0907 | 0.0907 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0175 | 0.0907 | 0.1008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0191 | 0.0179 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.0565 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0191 | 0.0191 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0056 | 0.0062 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0907 | 0.0907 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0191 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0012 | 0.0012 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0056 | 0.0056 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0056 | 0.0062 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0175 | 0.0907 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0056 | 0.0056 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0012 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Brugia malayi | PXA domain containing protein | 0.0175 | 0.0907 | 0.0907 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0165 | 0.0153 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0175 | 0.0907 | 0.0907 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.0565 | 0.8837 |
Loa Loa (eye worm) | RGS-3 protein | 0.0175 | 0.0907 | 0.0896 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0012 | 0.0012 |
Echinococcus multilocularis | expressed protein | 0.0175 | 0.0907 | 0.1008 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0056 | 0.0056 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0191 | 0.0212 |
Brugia malayi | hypothetical protein | 0.002 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0189 | 0.0177 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0191 | 0.0212 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0055 | 0.0215 | 0.0239 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1577 | 0.8992 | 0.8991 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0189 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0907 | 0.0896 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 0.0907 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0056 | 0.0062 |
Schistosoma mansoni | regulator of G protein signaling | 0.0175 | 0.0907 | 0.0907 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1577 | 0.8992 | 0.8991 |
Entamoeba histolytica | hypothetical protein | 0.0175 | 0.0907 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0165 | 0.0183 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.0931 | 0.0931 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.0565 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0191 | 0.2985 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0175 | 0.0907 | 0.0896 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0056 | 0.0056 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0175 | 0.0907 | 0.0907 |
Onchocerca volvulus | 0.0027 | 0.0056 | 0.2509 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23.72 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay | ChEMBL. | 24016057 |
MIC (functional) | = 50 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 7 days by microplate Alamar blue assay | ChEMBL. | 25462220 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.