Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 binding protein 1 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 4 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 3 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | PHD finger protein 23 | Starlite/ChEMBL | References |
Homo sapiens | Scm-like with four mbt domains 1 | Starlite/ChEMBL | References |
Homo sapiens | chromobox homolog 7 | Starlite/ChEMBL | References |
Homo sapiens | ubiquitin-like with PHD and ring finger domains 1 | Starlite/ChEMBL | References |
Homo sapiens | lysine (K)-specific demethylase 5A | Starlite/ChEMBL | References |
Homo sapiens | mbt domain containing 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.217 | 0.9827 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.217 | 0.9827 | 0.9706 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2207 | 1 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0318 | 0.1248 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.231 | 0.2068 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.029 | 0.029 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0115 | 0.0306 | 0.0306 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0115 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.217 | 0.9827 | 0.9822 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0111 | 0.029 | 0.029 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0137 | 0.0407 | 0.0407 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0624 | 0.2666 | 0.2666 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0318 | 0.1248 | 0.1248 |
Brugia malayi | mbt repeat family protein | 0.0331 | 0.1308 | 0.5001 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0093 | 0.0204 | 0.0204 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1303 | 0.5809 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.217 | 0.9827 | 0.9706 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0164 | 0.0534 | 0.0235 |
Toxoplasma gondii | PLU-1 family protein | 0.0053 | 0.0018 | 0.5 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0461 | 0.1909 | 0.1909 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0461 | 0.1909 | 0.1909 |
Brugia malayi | mbt repeat family protein | 0.0547 | 0.231 | 1 |
Onchocerca volvulus | 0.2207 | 1 | 1 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.029 | 0.029 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1303 | 0.5809 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0461 | 0.1909 | 0.1909 |
Schistosoma mansoni | hypothetical protein | 0.0392 | 0.159 | 0.159 |
Giardia lamblia | Hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0392 | 0.159 | 0.159 |
Brugia malayi | jmjC domain containing protein | 0.0164 | 0.0534 | 0.1139 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.1248 | 0.1248 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0392 | 0.159 | 0.159 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0624 | 0.2666 | 0.2666 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0115 | 0.0306 | 0.0306 |
Echinococcus granulosus | chromobox protein 2 | 0.0236 | 0.0867 | 0.0867 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.1248 | 0.1248 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0331 | 0.1308 | 0.1034 |
Schistosoma mansoni | hypothetical protein | 0.1027 | 0.4532 | 0.4532 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0547 | 0.231 | 0.1008 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0137 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.1265 | 0.5637 | 0.5499 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.217 | 0.9827 | 0.9706 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0115 | 0.0306 | 0.0306 |
Schistosoma mansoni | chromobox protein | 0.0236 | 0.0867 | 0.0867 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2207 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0115 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.2207 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0236 | 0.0867 | 0.0867 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.068 uM | Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assay | ChEMBL. | 24040942 |
IC50 (binding) | = 0.096 uM | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 3.7 uM | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.