Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin-like with PHD and ring finger domains 1 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 4 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | Scm-like with four mbt domains 1 | Starlite/ChEMBL | References |
Homo sapiens | lysine (K)-specific demethylase 5A | Starlite/ChEMBL | References |
Homo sapiens | chromobox homolog 7 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 3 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | tumor protein p53 binding protein 1 | Starlite/ChEMBL | References |
Homo sapiens | PHD finger protein 23 | Starlite/ChEMBL | References |
Homo sapiens | mbt domain containing 1 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0164 | 0.0534 | 0.1139 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0115 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.2207 | 1 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0137 | 0.0407 | 0.0407 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.1248 | 0.1248 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0318 | 0.1248 | 0.1248 |
Giardia lamblia | Hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Echinococcus granulosus | chromobox protein 2 | 0.0236 | 0.0867 | 0.0867 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0624 | 0.2666 | 0.2666 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0164 | 0.0534 | 0.0235 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.029 | 0.029 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0115 | 0.0306 | 0.0306 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0115 | 0.0306 | 0.0306 |
Toxoplasma gondii | PLU-1 family protein | 0.0053 | 0.0018 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.1248 | 0.1248 |
Echinococcus multilocularis | chromobox protein 2 | 0.0236 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.1265 | 0.5637 | 0.5499 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0461 | 0.1909 | 0.1909 |
Schistosoma mansoni | hypothetical protein | 0.0392 | 0.159 | 0.159 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.217 | 0.9827 | 0.9706 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0624 | 0.2666 | 0.2666 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.217 | 0.9827 | 0.9706 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0392 | 0.159 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.231 | 0.2068 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0115 | 0.0306 | 0.0306 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0392 | 0.159 | 0.159 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0331 | 0.1308 | 0.1034 |
Mycobacterium ulcerans | hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1303 | 0.5809 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0461 | 0.1909 | 0.1909 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1303 | 0.5809 | 0.5 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0318 | 0.1248 | 0.1248 |
Brugia malayi | mbt repeat family protein | 0.0547 | 0.231 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0111 | 0.029 | 0.029 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.217 | 0.9827 | 0.9706 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2207 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0236 | 0.0867 | 0.0867 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0137 | 0.0407 | 0.0407 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.217 | 0.9827 | 0.9706 |
Onchocerca volvulus | 0.2207 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.1027 | 0.4532 | 0.4532 |
Brugia malayi | mbt repeat family protein | 0.0331 | 0.1308 | 0.5001 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2207 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0093 | 0.0204 | 0.0204 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0547 | 0.231 | 0.1008 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2207 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1303 | 0.5809 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.217 | 0.9827 | 0.9822 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0461 | 0.1909 | 0.1909 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0115 | 0.0306 | 0.0306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.068 uM | Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assay | ChEMBL. | 24040942 |
IC50 (binding) | = 0.096 uM | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 3.7 uM | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.