TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 295.359 | Formula: C16H13N3OS
H donors: 0 H acceptors: 3 LogP: 2.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(C(=O)c1ccccc1)c1scc(n1)c1ccccn1
InChi: 1S/C16H13N3OS/c1-19(15(20)12-7-3-2-4-8-12)16-18-14(11-21-16)13-9-5-6-10-17-13/h2-11H,1H3
InChiKey: WXSYOVTXCIJSGO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0309	0.2365	0.2601
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0309	0.2365	0.2365
Echinococcus granulosus	protein kinase shaggy	0.0114	0.0415	0.0435
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0907	0.8339	0.9991
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0309	0.2365	0.2667
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0309	0.2365	0.2667
Brugia malayi	larval opioid receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0139	0.0658	0.049
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0333	0.0333
Entamoeba histolytica	casein kinase, putative	0.0908	0.8346	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0309	0.2365	0.2365
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Plasmodium vivax	serine/threonine kinase-1, putative	0.0139	0.0658	0.049
Schistosoma mansoni	hypothetical protein	0.0106	0.0333	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trypanosoma brucei	Casein kinase II	0.0908	0.8346	1
Brugia malayi	probable protein kinase	0.0187	0.1145	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Brugia malayi	Dopamine receptor protein 1	0.0309	0.2365	0.2601
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0333	0.2596	0.2596
Entamoeba histolytica	protein kinase domain containing protein	0.0352	0.2788	0.3125
Echinococcus granulosus	neuropeptide receptor A26	0.0309	0.2365	0.2787
Echinococcus granulosus	biogenic amine 5HT receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	sex peptide receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0319	0.007
Brugia malayi	GnHR receptor homolog	0.0309	0.2365	0.2601
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0309	0.2365	0.2787
Brugia malayi	Dopamine receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Echinococcus granulosus	cyclin dependent kinase	0.0105	0.0319	0.0319
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0309	0.2365	0.2787
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Echinococcus granulosus	neuropeptide Y receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	protein kinase	0.0138	0.0653	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0262	0.0262
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0139	0.0658	0.049
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus granulosus	dual specificity protein kinase clk2	0.0139	0.0658	0.0729
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0309	0.2365	0.2034
Echinococcus granulosus	neuropeptide FF receptor 2	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0262	0.009
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0309	0.2365	0.2787
Echinococcus multilocularis	neuropeptide Y receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	hypothetical protein	0.0106	0.0333	0.0087
Schistosoma mansoni	biogenic amine receptor	0.0309	0.2365	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	cyclin dependent kinase 5	0.0105	0.0319	0.0319
Leishmania major	protein kinase, putative	0.0139	0.0658	0.049
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0319	0.007
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Entamoeba histolytica	protein kinase domain containing protein	0.0114	0.0415	0.0189
Schistosoma mansoni	serine/threonine protein kinase	0.0333	0.2596	0.2951
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	serine/threonine protein kinase	0.0352	0.2788	0.3187
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus granulosus	cyclin dependent kinase 5	0.0105	0.0319	0.0319
Giardia lamblia	Kinase, CMGC CDK	0.0105	0.0319	0.007
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0114	0.0415	0.0189
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0105	0.0319	0.007
Leishmania major	protein kinase, putative	0.0139	0.0658	0.049
Schistosoma mansoni	neuropeptide F-like receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Brugia malayi	follicle stimulating hormone receptor	0.0309	0.2365	0.2601
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0114	0.0415	0.0189
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0106	0.0333	0.0087
Onchocerca volvulus		0.0309	0.2365	0.2034
Echinococcus granulosus	7tm_1 domain containing protein	0.0309	0.2365	0.2787
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0333	0.0176
Loa Loa (eye worm)	CDC7 protein kinase	0.0132	0.0589	0.0589
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0333	0.2596	0.3066
Echinococcus multilocularis	g-protein coupled receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0114	0.0415	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	growth hormone secretagogue receptor	0.0309	0.2365	0.2667
Mycobacterium leprae	Possible transporter protein	0.0106	0.0333	0.5
Brugia malayi	jmjC domain containing protein	0.0115	0.0426	0.0202
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.0106	0.0333	0.0087
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0139	0.0658	0.049
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0099	0.0262	0.0262
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0319	0.0159
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0106	0.0333	0.0087
Onchocerca volvulus		0.0309	0.2365	0.2034
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0139	0.0658	0.049
Onchocerca volvulus		0.0309	0.2365	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Giardia lamblia	Kinase, CMGC CDK	0.0105	0.0319	0.007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Schistosoma mansoni	amine GPCR	0.0309	0.2365	0.2667
Trypanosoma cruzi	cdc2-related kinase 1	0.0105	0.0319	0.007
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0114	0.0415	0.0189
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Loa Loa (eye worm)	TYRA-2 protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	orexin receptor type 2	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0114	0.0415	0.0415
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0352	0.2788	0.2788
Trypanosoma brucei	cdc2-related kinase 3	0.0105	0.0319	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0309	0.2365	0.2787
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0138	0.0653	0.0653
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0114	0.0415	0.0435
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0309	0.2365	0.2787
Onchocerca volvulus		0.0309	0.2365	0.2034
Echinococcus granulosus	rho-associated protein kinase 1	0.0306	0.2329	0.2744
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0309	0.2365	0.2034
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0333	0.2596	0.2887
Schistosoma mansoni	hypothetical protein	0.0309	0.2365	0.2667
Brugia malayi	Protein kinase domain containing protein	0.0139	0.0658	0.049
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.0106	0.0333	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0132	0.0589	0.0404
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	protein kinase shaggy	0.0114	0.0415	0.0435
Trichomonas vaginalis	CMGC family protein kinase	0.0114	0.0415	0.0189
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0118	0.045	0.045
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.0589	0.0491
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus granulosus	neuropeptide Y receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis		0.0138	0.0653	0.0723
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0166	0.0936	0.1064
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	G-protein coupled receptor	0.0309	0.2365	0.2365
Echinococcus granulosus	fmrfamide receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0309	0.2365	0.2667
Schistosoma mansoni	biogenic amine receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	cyclin dependent kinase 1	0.0105	0.0319	0.0319
Brugia malayi	cell division control protein 2 homolog	0.0105	0.0319	0.007
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0309	0.2365	0.2667
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Schistosoma mansoni	protein kinase	0.0187	0.1145	0.1172
Schistosoma mansoni	hypothetical protein	0.0309	0.2365	0.2667
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0139	0.0658	0.049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0309	0.2365	0.2667
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0309	0.2365	0.2667
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0309	0.2365	0.2667
Schistosoma mansoni	neuropeptide receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0658	0.0575
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	g protein coupled receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Onchocerca volvulus		0.0309	0.2365	0.2034
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0309	0.2365	0.2667
Entamoeba histolytica	cell division protein kinase 2, putative	0.0105	0.0319	0.007
Echinococcus granulosus	neuropeptides capa receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0106	0.0333	0.0087
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0319	0.0159
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0106	0.0333	0.0087
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0105	0.0319	0.007
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0139	0.0658	0.0729
Brugia malayi	Serotonin receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0105	0.0319	0.0319
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0106	0.0333	0.0087
Brugia malayi	neuropeptide F receptor	0.0309	0.2365	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0105	0.0319	0.007
Echinococcus granulosus	orexin receptor type 2	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0114	0.0415	0.0435
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0908	0.8346	0.8346
Loa Loa (eye worm)	neuropeptide F receptor	0.0309	0.2365	0.2365
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	g protein coupled receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0907	0.8339	0.8339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Schistosoma mansoni	amine GPCR	0.0309	0.2365	0.2667
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0309	0.2365	0.2365
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	somatostatin receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0908	0.8346	1
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate cyclase type, putative	0.0106	0.0333	0.0087
Brugia malayi	G-protein coupled receptor	0.0309	0.2365	0.2601
Echinococcus multilocularis	dro:myosuppressin receptor	0.0309	0.2365	0.2787
Entamoeba histolytica	protein kinase, putative	0.0114	0.0415	0.0189
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0333	0.0176
Onchocerca volvulus		0.0285	0.212	0.1779
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0426	0.0449
Trypanosoma brucei	protein kinase, putative	0.0114	0.0415	0.0189
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0139	0.0658	0.049
Echinococcus multilocularis	neuropeptide Y receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase type III, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	tm gpcr rhodopsin	0.0309	0.2365	0.2787
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0114	0.0415	0.0189
Giardia lamblia	Kinase, CDC7	0.0132	0.0589	0.0404
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	neuropeptide receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0114	0.0415	0.0415
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Schistosoma mansoni	neuropeptide f receptor 76f	0.0309	0.2365	0.2667
Trypanosoma cruzi	cdc2-related kinase 3	0.0105	0.0319	0.007
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0106	0.0333	0.0087
Brugia malayi	RE15519p	0.0309	0.2365	0.2601
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0589	0.0404
Schistosoma mansoni	60S ribosomal protein L21	0.0106	0.0333	0.0176
Echinococcus granulosus	casein kinase ii subunit alpha	0.0908	0.8346	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	neuropeptides capa receptor	0.0309	0.2365	0.2787
Onchocerca volvulus		0.1074	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0309	0.2365	0.2787
Onchocerca volvulus		0.0309	0.2365	0.2034
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Schistosoma mansoni	amine GPCR	0.0309	0.2365	0.2667
Echinococcus multilocularis	fmrfamide receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Onchocerca volvulus		0.0132	0.0589	0.0182
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0106	0.0333	0.0087
Entamoeba histolytica	cell division protein kinase 2, putative	0.0105	0.0319	0.007
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0309	0.2365	0.2787
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0309	0.2365	0.2787
Echinococcus multilocularis	neuropeptide receptor A26	0.0309	0.2365	0.2787
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0105	0.0319	0.0319
Schistosoma mansoni	biogenic amine receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	single minded 2	0.0106	0.0333	0.0336
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trypanosoma cruzi	cdc2-related kinase 3	0.0105	0.0319	0.007
Loa Loa (eye worm)	hypothetical protein	0.0084	0.011	0.011
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Schistosoma mansoni	hypothetical protein	0.0309	0.2365	0.2667
Echinococcus multilocularis	fmrfamide receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	serotonin receptor	0.0309	0.2365	0.2787
Onchocerca volvulus		0.0309	0.2365	0.2034
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Echinococcus granulosus	G protein coupled receptor 139	0.0309	0.2365	0.2787
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	g protein coupled receptor	0.0309	0.2365	0.2787
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0127	0.0541	0.0345
Echinococcus multilocularis	cyclin dependent kinase	0.0105	0.0319	0.0319
Schistosoma mansoni	opsin-like receptor	0.0309	0.2365	0.2667
Plasmodium falciparum	protein serine/threonine kinase-1	0.0139	0.0658	0.049
Echinococcus granulosus	homeodomain interacting protein kinase 3	0.0352	0.2788	0.3298
Schistosoma mansoni	serine/threonine protein kinase	0.0306	0.2329	0.2623
Schistosoma mansoni	opsin-like receptor	0.0309	0.2365	0.2667
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0309	0.2365	0.2787
Plasmodium falciparum	glycogen synthase kinase 3	0.0114	0.0415	0.0189
Brugia malayi	Homeodomain interacting protein kinase protein 1	0.0352	0.2788	0.3125
Brugia malayi	Melatonin receptor type 1A	0.0309	0.2365	0.2601
Schistosoma mansoni	adenoreceptor	0.0309	0.2365	0.2667
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0139	0.0658	0.049
Plasmodium falciparum	protein kinase 5	0.0105	0.0319	0.007
Schistosoma mansoni	hypothetical protein	0.0309	0.2365	0.2667
Entamoeba histolytica	protein kinase domain containing protein	0.0114	0.0415	0.0189
Onchocerca volvulus		0.0309	0.2365	0.2034
Onchocerca volvulus		0.0309	0.2365	0.2034
Brugia malayi	intracellular kinase	0.0114	0.0415	0.0189
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0106	0.0333	0.0087
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0309	0.2365	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trypanosoma cruzi	cdc2-related kinase 1	0.0105	0.0319	0.007
Echinococcus granulosus	tm gpcr rhodopsin	0.0309	0.2365	0.2787
Onchocerca volvulus		0.0309	0.2365	0.2034
Brugia malayi	putative neuropeptide receptor	0.0309	0.2365	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Giardia lamblia	Kinase, CMGC GSK	0.0114	0.0415	0.0189
Echinococcus granulosus	g protein coupled receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0309	0.2365	0.2787
Echinococcus multilocularis	neuropeptides capa receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	neuropeptide receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Onchocerca volvulus		0.0309	0.2365	0.2034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	biogenic amine 5HT receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	sex peptide receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	amine GPCR	0.0309	0.2365	0.2667
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0333	0.2596	0.2596
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Schistosoma mansoni	histamine h1 receptor	0.0309	0.2365	0.2667
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0105	0.0319	0.0319
Onchocerca volvulus		0.0309	0.2365	0.2034
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0309	0.2365	0.2365
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0589	0.0404
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0319	0.007
Echinococcus multilocularis	serotonin receptor	0.0309	0.2365	0.2787
Giardia lamblia	Kinase, CMGC GSK	0.0114	0.0415	0.0189
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0309	0.2365	0.2365
Trichomonas vaginalis	adenylate cyclase type, putative	0.0106	0.0333	0.0087
Trypanosoma brucei	cdc2-related kinase 1	0.0105	0.0319	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Leishmania major	casein kinase II, putative	0.0908	0.8346	1
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0333	0.2596	0.3066
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0262	0.009
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0319	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	neuropeptide receptor	0.0309	0.2365	0.2787
Brugia malayi	AKH receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Onchocerca volvulus		0.0309	0.2365	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	voltage gated potassium channel	0.0106	0.0333	0.0336
Echinococcus multilocularis	g protein coupled receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	g-protein coupled receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	neuropeptide receptor	0.0309	0.2365	0.2667
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0333	0.0176
Trichomonas vaginalis	CMGC family protein kinase	0.0908	0.8346	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	allatostatin A receptor	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	neuropeptides capa receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	rho associated protein kinase	0.0306	0.2329	0.2744
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0589	0.0404
Onchocerca volvulus		0.0309	0.2365	0.2034
Trypanosoma cruzi	casein kinase II, putative	0.0908	0.8346	1
Onchocerca volvulus		0.0309	0.2365	0.2034
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Echinococcus multilocularis	somatostatin receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	hypothetical protein	0.0309	0.2365	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	CDC7 cell division cycle 7	0.0132	0.0589	0.0646
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0139	0.0658	0.0658
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Giardia lamblia	Kinase, CMGC CK2	0.0908	0.8346	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	melatonin receptor type 1A	0.0309	0.2365	0.2365
Echinococcus granulosus	voltage gated potassium channel	0.0106	0.0333	0.0336
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0658	0.0575
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Onchocerca volvulus		0.0309	0.2365	0.2034
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	CDC7 cell division cycle 7	0.0132	0.0589	0.0646
Brugia malayi	putative neuropeptide receptor NPR1	0.0309	0.2365	0.2601
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0908	0.8346	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0099	0.0262	0.0251
Brugia malayi	neuropeptide F receptor	0.0309	0.2365	0.2601
Brugia malayi	G protein-coupled receptor F59B2.13	0.0309	0.2365	0.2601
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis		0.0118	0.045	0.0477
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0309	0.2365	0.2601
Brugia malayi	Casein kinase II, alpha chain	0.0908	0.8346	1
Brugia malayi	Dopamine receptor protein 2	0.0309	0.2365	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0936	0.0936
Echinococcus granulosus	serotonin receptor	0.0309	0.2365	0.2787
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0309	0.2365	0.2601
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0309	0.2365	0.2787
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0262	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	G protein coupled receptor 139	0.0309	0.2365	0.2787
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0309	0.2365	0.2667
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0309	0.2365	0.2787
Echinococcus granulosus	g protein coupled receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0106	0.0333	0.0336
Onchocerca volvulus		0.0132	0.0589	0.0182
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	hypothetical protein	0.0118	0.045	0.0477
Brugia malayi	ORL1-like opioid receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0309	0.2365	0.2787
Echinococcus multilocularis	homeodomain interacting protein kinase 3	0.0352	0.2788	0.3298
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus granulosus	neuropeptide s receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0333	0.0176
Giardia lamblia	Kinase, CMGC CLK	0.0139	0.0658	0.049
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	myosin xvIII	0.0309	0.2365	0.2667
Trichomonas vaginalis	CMGC family protein kinase	0.0114	0.0415	0.0189
Toxoplasma gondii	CMGC kinase, CK2 family	0.0908	0.8346	1
Plasmodium vivax	protein kinase Crk2	0.0105	0.0319	0.007
Echinococcus granulosus	protein kinase	0.0138	0.0653	0.0723
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0309	0.2365	0.2787
Echinococcus multilocularis	neuropeptide s receptor	0.0309	0.2365	0.2787
Schistosoma mansoni	amine GPCR	0.0309	0.2365	0.2667
Brugia malayi	Serotonin receptor	0.0309	0.2365	0.2601
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Brugia malayi	G protein-coupled receptor	0.0309	0.2365	0.2601
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0908	0.8346	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0309	0.2365	0.2787
Brugia malayi	G-protein coupled receptor	0.0309	0.2365	0.2601
Entamoeba histolytica	protein kinase domain containing protein	0.0908	0.8346	1
Echinococcus granulosus	allatostatin A receptor	0.0309	0.2365	0.2787
Loa Loa (eye worm)	G-protein coupled receptor	0.0309	0.2365	0.2365
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Onchocerca volvulus		0.0306	0.2329	0.1997
Onchocerca volvulus		0.0309	0.2365	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	CMGC family protein kinase	0.0139	0.0658	0.049
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.0106	0.0333	0.0087
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0309	0.2365	0.2601
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0309	0.2365	0.2787
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0309	0.2365	0.2601
Trichomonas vaginalis	adenylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Schistosoma mansoni	neuropeptide F-like receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	adenylate cyclase type, putative	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	neuropeptide receptor	0.0309	0.2365	0.2667
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0333	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.0333	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0309	0.2365	0.2667
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0309	0.2365	0.2787
Loa Loa (eye worm)	neuropeptide F receptor	0.0309	0.2365	0.2365
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0105	0.0319	0.0319
Brugia malayi	hypothetical protein	0.0309	0.2365	0.2601
Echinococcus multilocularis	cyclin dependent kinase 1	0.0105	0.0319	0.0319
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0106	0.0333	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0309	0.2365	0.2787
Plasmodium vivax	unspecified product	0.0908	0.8346	1
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	opsin-like receptor	0.0309	0.2365	0.2667
Schistosoma mansoni	protein kinase	0.0908	0.8346	1
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.0106	0.0333	0.0087
Schistosoma mansoni	neuropeptide receptor	0.0309	0.2365	0.2667
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0333	0.2596	0.2276
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0333	0.2596	0.2887
Loa Loa (eye worm)	hypothetical protein	0.0309	0.2365	0.2365
Echinococcus multilocularis	cyclin dependent kinase 1	0.0105	0.0319	0.0319
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0099	0.0262	0.0262
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0309	0.2365	0.2601
Echinococcus multilocularis	neuropeptide receptor	0.0309	0.2365	0.2787
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Echinococcus granulosus	rhodopsin orphan GPCR	0.0309	0.2365	0.2787
Echinococcus granulosus	dro:myosuppressin receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0426	0.0449
Brugia malayi	sulfakinin receptor protein	0.0309	0.2365	0.2601
Trichomonas vaginalis	guanylate cyclase, putative	0.0106	0.0333	0.0087
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0309	0.2365	0.2787
Echinococcus granulosus	tm gpcr rhodopsin	0.0309	0.2365	0.2787

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC99 (functional)	>= 25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv in GAST media with glycerol and alanine after 7 to 14 days by broth microdilution method	ChEMBL.	24075144
MIC99 (functional)	> 25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv in Middlebrook 7H9 broth with glucose after 7 to 14 days by broth microdilution method	ChEMBL.	24075144

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441172

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789824