Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1068 | 0.8994 | 0.8994 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0118 | 0.0925 | 0.1028 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1068 | 0.8994 | 0.8994 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0084 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0084 | 0.0084 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0084 | 0.0084 |
Schistosoma mansoni | lipoxygenase | 0.0019 | 0.0084 | 0.0084 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.0381 | 0.0381 |
Brugia malayi | PXA domain containing protein | 0.0118 | 0.0925 | 0.0925 |
Brugia malayi | PXA domain containing protein | 0.0118 | 0.0925 | 0.0925 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0118 | 0.0925 | 0.1028 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0084 | 0.0084 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0084 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | axis inhibition protein axin | 0.0118 | 0.0925 | 0.1028 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1068 | 0.8994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0121 | 0.0949 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0084 | 0.0084 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0118 | 0.0925 | 0.1028 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0118 | 0.0925 | 0.1028 |
Schistosoma mansoni | regulator of G protein signaling | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0118 | 0.0925 | 0.1028 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0084 | 0.0084 |
Schistosoma mansoni | regulator of G protein signaling | 0.0118 | 0.0925 | 0.0925 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0118 | 0.0925 | 0.1028 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0084 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0118 | 0.0925 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0084 | 0.0094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0084 | 0.0084 |
Brugia malayi | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Echinococcus multilocularis | expressed protein | 0.0118 | 0.0925 | 0.1028 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0084 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0118 | 0.0925 | 0.1028 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0118 | 0.0925 | 0.0925 |
Schistosoma mansoni | regulator of G protein signaling | 0.0118 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0118 | 0.0925 | 0.0925 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0118 | 0.0925 | 0.1028 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0084 | 0.0094 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0084 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0084 | 0.0084 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0084 | 0.0094 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0121 | 0.0949 | 0.1055 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0118 | 0.0925 | 0.1028 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0118 | 0.0925 | 0.1028 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 0.0949 | 0.0949 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1068 | 0.8994 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0084 | 0.0084 |
Schistosoma mansoni | regulator of G protein signaling | 0.0118 | 0.0925 | 0.0925 |
Schistosoma mansoni | regulator of G protein signaling | 0.0118 | 0.0925 | 0.0925 |
Onchocerca volvulus | 0.0019 | 0.0084 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.1186 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.1108 | 0.1108 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0118 | 0.0925 | 0.1028 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1068 | 0.8994 | 0.8994 |
Brugia malayi | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0084 | 0.0084 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0118 | 0.0925 | 0.0925 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1186 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.1108 | 0.1108 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0118 | 0.0925 | 0.1028 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0118 | 0.0925 | 0.1028 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0118 | 0.0925 | 0.1028 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0118 | 0.0925 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0118 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | RGS-3 protein | 0.0118 | 0.0925 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0118 | 0.0925 | 0.0925 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 0.0949 | 0.0949 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.0381 | 0.0424 |
Echinococcus granulosus | expressed protein | 0.0118 | 0.0925 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | RUN | 0.0019 | 0.0084 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0925 | 0.0925 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.0381 | 0.0424 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.1108 | 0.1108 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0118 | 0.0925 | 0.1028 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0118 | 0.0925 | 0.0925 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0925 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0121 | 0.0949 | 0.1055 |
Schistosoma mansoni | axis inhibition protein axin | 0.0118 | 0.0925 | 0.0925 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0118 | 0.0925 | 0.1028 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0118 | 0.0925 | 0.0925 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0118 | 0.0925 | 0.0925 |
Onchocerca volvulus | 0.0019 | 0.0084 | 0.5 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0084 | 0.0094 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0084 | 0.0084 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli at 2 to 64 ug/ml after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference | |
IZ (functional) | = 12 mm | Antifungal activity against Candida albicans at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | Antifungal activity against Saccharomyces cerevisiae after 7 days by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | Antibacterial activity against Escherichia coli after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans after 7 days by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.