TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.165 | Formula: C9H10BrN3S
H donors: 2 H acceptors: 0 LogP: 2.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C(\c1cccc(c1)Br)/C
InChi: 1S/C9H10BrN3S/c1-6(12-13-9(11)14)7-3-2-4-8(10)5-7/h2-5H,1H3,(H3,11,13,14)/b12-6-
InChiKey: WJQYKRIBWNZUHM-SDQBBNPISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PXA domain containing protein	0.0119	0.0894	0.0894
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Onchocerca volvulus		0.002	0.0057	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0057	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0057	0.5
Onchocerca volvulus		0.002	0.0057	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Onchocerca volvulus		0.002	0.0057	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0119	0.0894	1
Loa Loa (eye worm)	fibroinase	0.002	0.0057	0.0057
Echinococcus granulosus	regulator of G protein signaling 3	0.0119	0.0894	0.0995
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0057	0.0057
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0119	0.0894	0.0894
Brugia malayi	hypothetical protein	0.0119	0.0894	0.0894
Echinococcus multilocularis	axis inhibition protein axin	0.0119	0.0894	0.0937
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Entamoeba histolytica	hypothetical protein	0.0119	0.0894	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0057	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1073	0.8991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0539	1
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0057	0.0057
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Echinococcus multilocularis	regulator of G protein signaling	0.0119	0.0894	0.0937
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0539	1
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0057	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1192	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Schistosoma mansoni	z-protein (S1r protein)	0.0119	0.0894	0.0894
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.0919	0.0919
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0119	0.0894	0.0894
Echinococcus multilocularis	regulator of G protein signaling 3	0.0119	0.0894	0.0937
Echinococcus granulosus	cathepsin l1	0.002	0.0057	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0119	0.0894	0.0894
Leishmania major	cathepsin L-like protease	0.0077	0.0539	1
Echinococcus granulosus	axis inhibition protein axin	0.0119	0.0894	0.0995
Schistosoma mansoni	regulator of G protein signaling	0.0119	0.0894	0.0894
Toxoplasma gondii	cathepsin CPL	0.002	0.0057	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0057	0.0057
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0057	1
Brugia malayi	hypothetical protein	0.0119	0.0894	0.0894
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0057	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0119	0.0894	0.0894
Echinococcus multilocularis	axis inhibition protein axin	0.0119	0.0894	0.0937
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0119	0.0894	0.0937
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0122	0.0919	0.1022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0482	0.8824
Plasmodium vivax	vivapain-2	0.002	0.0057	0.5
Echinococcus multilocularis	regulator of G protein signaling 7	0.0119	0.0894	0.0937
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1073	0.8991	0.8991
Entamoeba histolytica	hypothetical protein	0.0119	0.0894	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0119	0.0894	0.0894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Echinococcus multilocularis	expressed protein	0.0119	0.0894	0.0937
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Leishmania major	cathepsin L-like protease	0.0077	0.0539	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1073	0.8991	0.8991
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0399	0.7098
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0119	0.0894	0.0937
Echinococcus granulosus	Regulator of G protein signaling 20	0.0119	0.0894	0.0995
Leishmania major	cathepsin L-like protease	0.0077	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0122	0.0919	0.0965
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0057	0.5
Echinococcus granulosus	regulator of G protein signaling 3	0.0119	0.0894	0.0995
Loa Loa (eye worm)	ctsf protein	0.002	0.0057	0.0057
Echinococcus granulosus	expressed protein	0.0119	0.0894	0.0995
Onchocerca volvulus		0.002	0.0057	1
Schistosoma mansoni	axis inhibition protein axin	0.0119	0.0894	0.0894
Entamoeba histolytica	hypothetical protein	0.0119	0.0894	1
Onchocerca volvulus		0.002	0.0057	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0119	0.0894	0.0894
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0119	0.0894	0.0894
Schistosoma mansoni	regulator of G protein signaling	0.0119	0.0894	0.0894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Onchocerca volvulus		0.002	0.0057	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0057	0.0057
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0119	0.0894	0.0937
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1073	0.8991	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1073	0.8991	0.8991
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.0919	0.0919
Plasmodium vivax	vivapain-2	0.002	0.0057	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0057	0.0634
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0057	0.0057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.1192	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0894	0.0894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0539	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0119	0.0894	0.0995
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0057	0.5
Echinococcus multilocularis	regulator of G protein signaling 7	0.0119	0.0894	0.0937
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Loa Loa (eye worm)	RGS-3 protein	0.0119	0.0894	0.0894
Schistosoma mansoni	regulator of G protein signaling	0.0119	0.0894	0.0894
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0057	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0122	0.0919	0.0919
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Brugia malayi	PXA domain containing protein	0.0119	0.0894	0.0894
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0119	0.0894	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0894	1
Onchocerca volvulus		0.002	0.0057	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Brugia malayi	A-kinase anchor protein 10, precursor	0.0119	0.0894	0.0894
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0119	0.0894	0.0995
Brugia malayi	Cathepsin L-like precursor	0.002	0.0057	0.0057
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0057	0.0057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0057	0.0634
Schistosoma mansoni	regulator of G protein signaling	0.0119	0.0894	0.0894
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0539	1
Schistosoma mansoni	regulator of G protein signaling	0.0119	0.0894	0.0894
Echinococcus granulosus	regulator of G protein signaling 7	0.0119	0.0894	0.0995
Loa Loa (eye worm)	PXA domain-containing protein	0.0119	0.0894	0.0894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0057	0.0634
Schistosoma mansoni	axis inhibition protein axin	0.0119	0.0894	0.0894
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5
Echinococcus granulosus	axis inhibition protein axin	0.0119	0.0894	0.0995
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0057	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0539	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 70.4 uM	Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of parasite proliferation after 72 hr by Lilit Alamar Blue method	ChEMBL.	No reference
Inhibition (binding)	= 24 %	Inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-AMC as substrate at 0.3 uM incubated for 5 mins prior to substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	No reference
Inhibition (binding)	= 79 %	Inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-AMC as substrate at 2 uM incubated for 5 mins prior to substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	No reference
Inhibition (binding)	= 80 %	Inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-AMC as substrate at 10 uM incubated for 5 mins prior to substrate addition measured after 10 mins by fluorescence assay	ChEMBL.	No reference
Ki (binding)	= 142 nM	Non-competitive inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-AMC as substrate assessed as function of velocity after 30 mins	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2297590

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791248