Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | egl-9 family hypoxia-inducible factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Neospora caninum | 2OG-Fe(II) oxygenase family protein, putative | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0292 | 0.0563 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1298 | 0.2581 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0439 | 0.3642 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0292 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0439 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0292 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0292 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0112 | 0.0225 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0292 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0292 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.0439 | 1 |
Onchocerca volvulus | 0.004 | 0.0292 | 0.0563 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0439 | 0.0429 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0439 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0292 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0419 | 0.4995 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.2969 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0292 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0292 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0292 | 0.0281 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0292 | 0.0585 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0292 | 0.2388 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1298 | 0.2598 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0439 | 0.3642 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.1187 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0292 | 0.0563 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0292 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0292 | 0.2385 |
Brugia malayi | hypothetical protein | 0.004 | 0.0292 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0112 | 0.3604 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1298 | 0.2581 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0439 | 0.3642 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.3604 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0292 | 0.6558 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0292 | 0.0585 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0292 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0292 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0292 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0292 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.3586 | 0.7173 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0292 | 0.5 |
Brugia malayi | prolyl 4-hydroxylase | 0.0017 | 0.0011 | 0.0022 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0292 | 0.2388 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0439 | 0.0859 |
Onchocerca volvulus | 0.0419 | 0.4995 | 1 | |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0292 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0292 | 0.655 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0292 | 0.5 |
Brugia malayi | beta-lactamase | 0.004 | 0.0292 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0112 | 0.0203 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0292 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0292 | 0.5 |
Onchocerca volvulus | 0.0419 | 0.4995 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0164 | 0.1831 | 0.3666 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0292 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0292 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0419 | 0.4995 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0112 | 0.1187 | 0.2376 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.0439 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1187 | 0.2359 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0164 | 0.1831 | 0.3666 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0292 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0292 | 0.0563 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.0439 | 0.088 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0164 | 0.1831 | 0.3652 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.0439 | 0.0859 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0292 | 0.0281 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0292 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0292 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0563 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.3604 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0292 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0439 | 0.0429 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0292 | 0.2385 |
Onchocerca volvulus | 0.004 | 0.0292 | 0.0563 | |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0439 | 0.3642 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0112 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1831 | 0.3652 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.0439 | 0.0429 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 | Inhibition of PHD2 (unknown origin) by HTRF assay | ChEMBL. | 24055079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.