Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MBOAT family protein | 0.0026 | 0.0382 | 0.0382 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0153 | 1 | 1 |
Schistosoma mansoni | plexin | 0.0036 | 0.1121 | 0.1121 |
Trypanosoma cruzi | GUP1, putative | 0.0026 | 0.0382 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0153 | 1 | 1 |
Trichomonas vaginalis | porcupine, putative | 0.0026 | 0.0382 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0382 | 0.0382 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0382 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0026 | 0.0382 | 0.0382 |
Leishmania major | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0026 | 0.0382 | 0.0382 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0036 | 0.1121 | 0.0768 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0026 | 0.0382 | 0.0382 |
Trypanosoma cruzi | GUP1, putative | 0.0026 | 0.0382 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0026 | 0.0382 | 0.0382 |
Leishmania major | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0026 | 0.0382 | 0.0382 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0026 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8057 | 0.8057 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0026 | 0.0382 | 0.0382 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.1121 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0382 | 0.0382 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0153 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0382 | 0.0382 |
Leishmania major | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0026 | 0.0382 | 0.0382 |
Echinococcus granulosus | plexin a4 | 0.0042 | 0.1612 | 0.1279 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0153 | 1 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0042 | 0.1612 | 0.1279 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0026 | 0.0382 | 0.0382 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0153 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0382 | 0.0382 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0382 | 0.5 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0026 | 0.0382 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0026 | 0.0382 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0382 | 0.0382 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0026 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | MBOAT family protein | 0.0026 | 0.0382 | 0.0382 |
Brugia malayi | plexin A | 0.0042 | 0.1612 | 0.1279 |
Loa Loa (eye worm) | plexin A | 0.0042 | 0.1612 | 0.1612 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0026 | 0.0382 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0026 | 0.0382 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0026 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1121 | 0.1121 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0382 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0026 | 0.0382 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0026 | 0.0382 | 0.5 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0026 | 0.0382 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0026 | 0.0382 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0153 | 1 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0153 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 179 nM | Inhibition of human DGAT-1 expressed in insect Sf9 cell microsomes using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA as substrate after 2 hrs | ChEMBL. | 24120540 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.