Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0081 | 0.0081 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0079 | 0.0079 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0011 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0011 | 0.0322 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0048 | 0.0037 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0021 | 0.001 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.0079 | 0.0069 |
Schistosoma mansoni | kinase | 0.0055 | 0.0073 | 0.0073 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.0079 | 0.0069 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.112 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.0622 | 0.0612 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0742 | 0.0742 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1228 | 0.5822 | 1 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0079 | 0.2384 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0066 | 0.1995 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0107 | 0.033 | 0.033 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0011 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0107 | 0.033 | 0.0549 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0011 | 0.0011 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | hypothetical protein | 0.0186 | 0.0714 | 0.1211 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0083 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2046 | 0.9828 | 0.9828 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Echinococcus granulosus | geminin | 0.0191 | 0.0742 | 0.0742 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.019 | 0.019 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0107 | 0.033 | 0.9904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1228 | 0.5822 | 1 |
Giardia lamblia | Kinase, PLK | 0.0107 | 0.033 | 0.0436 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.033 | 0.033 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.0224 | 0.0224 |
Onchocerca volvulus | 0.2081 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0186 | 0.0714 | 0.6344 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0011 | 0.0322 |
Trypanosoma brucei | polo-like protein kinase | 0.0107 | 0.033 | 0.0319 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2046 | 0.9828 | 0.9828 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0037 | 0.0027 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.0079 | 0.9446 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Brugia malayi | jmjC domain containing protein | 0.0108 | 0.0333 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0011 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0021 | 0.0021 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0066 | 0.0066 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1228 | 0.5822 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.0101 | 0.009 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2081 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.019 | 0.5712 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0079 | 0.0079 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0011 | 0.0318 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0888 | 0.4155 | 0.4149 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0021 | 0.0626 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0107 | 0.033 | 0.0319 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Loa Loa (eye worm) | hypothetical protein | 0.2081 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.2046 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | hypothetical protein | 0.1193 | 0.565 | 0.565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.