Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0081 | 0.0081 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2081 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0011 | 0.0322 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0079 | 0.0079 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0011 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0048 | 0.0037 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.112 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.0079 | 0.0069 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.0079 | 0.0069 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0021 | 0.001 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Schistosoma mansoni | kinase | 0.0055 | 0.0073 | 0.0073 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.0622 | 0.0612 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0011 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0066 | 0.1995 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0079 | 0.2384 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0107 | 0.033 | 0.033 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1228 | 0.5822 | 1 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | hypothetical protein | 0.0186 | 0.0714 | 0.1211 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0107 | 0.033 | 0.0549 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0011 | 0.0011 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2046 | 0.9828 | 0.9828 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0083 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Echinococcus granulosus | geminin | 0.0191 | 0.0742 | 0.0742 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Giardia lamblia | Kinase, PLK | 0.0107 | 0.033 | 0.0436 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1228 | 0.5822 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0107 | 0.033 | 0.9904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.019 | 0.019 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.0224 | 0.0224 |
Onchocerca volvulus | 0.2081 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.033 | 0.033 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2046 | 0.9828 | 0.9828 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0037 | 0.0027 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0011 | 0.0322 |
Trypanosoma brucei | polo-like protein kinase | 0.0107 | 0.033 | 0.0319 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0186 | 0.0714 | 0.6344 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0021 | 0.0021 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0066 | 0.0066 |
Brugia malayi | jmjC domain containing protein | 0.0108 | 0.0333 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0011 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.0079 | 0.9446 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0011 | 0.0318 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0079 | 0.0079 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0888 | 0.4155 | 0.4149 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.0101 | 0.009 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2081 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.019 | 0.5712 |
Mycobacterium ulcerans | hypothetical protein | 0.1228 | 0.5822 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.2081 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.2046 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | hypothetical protein | 0.1193 | 0.565 | 0.565 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0107 | 0.033 | 0.0319 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0021 | 0.0626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.