Detailed information for compound 1799953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.371 | Formula: C19H18N4O4
  • H donors: 3 H acceptors: 4 LogP: -1.67 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(CCC(=O)n1c(nc2c(c1=O)cccc2)c1ccc(cc1)N)N
  • InChi: 1S/C19H18N4O4/c20-12-7-5-11(6-8-12)17-22-15-4-2-1-3-13(15)18(25)23(17)16(24)10-9-14(21)19(26)27/h1-8,14H,9-10,20-21H2,(H,26,27)
  • InChiKey: BTSIFQLMYJHOII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0157 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0199 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2346 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.4737 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.079 0.1113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.043 0.0607
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.066 0.093
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0322 0.2648
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0674 0.2873
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0177 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.1305 0.184
Brugia malayi hypothetical protein 0.0455 0.7094 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0551 0.866 1
Leishmania major mitochondrial DNA polymerase beta 0.031 0.4737 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.1504 0.6408
Loa Loa (eye worm) hypothetical protein 0.0153 0.2184 0.3079
Brugia malayi Kinesin motor domain containing protein 0.0082 0.1025 0.1445
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1629 0.2297
Loa Loa (eye worm) hypothetical protein 0.0455 0.7094 1
Trypanosoma brucei polo-like protein kinase 0.0094 0.1215 0.2565
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0199 0.0419
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.2046 0.2883
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0257 0.0362
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1504 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1305 0.184
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.079 0.079
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0137 0.0192
Echinococcus multilocularis GPCR, family 2 0.0031 0.0198 0.0198
Giardia lamblia Kinesin-5 0.0082 0.1025 0.844
Brugia malayi MH2 domain containing protein 0.0119 0.1629 0.2297
Onchocerca volvulus 0.0455 0.7094 1
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.1504 0.1504
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0199 0.0199
Onchocerca volvulus 0.0155 0.2213 0.2984
Brugia malayi intermediate filament protein 0.0028 0.0137 0.0192
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.2076 0.4383
Schistosoma mansoni lamin 0.0028 0.0137 0.0158
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.4737 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0177 0.1722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.043 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.043 0.0497
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1215 0.808
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1504 1
Brugia malayi Muscleblind-like protein 0.0153 0.2184 0.3079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0257 0.0297
Schistosoma mansoni kinesin eg-5 0.0082 0.1025 0.1184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0199 0.0199
Onchocerca volvulus Alhambra homolog 0.0029 0.0157 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0495 0.0697
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0199 0.0847
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0674 0.0778
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0177 0.1722
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0177 0.1175
Echinococcus granulosus lamin dm0 0.0028 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0228
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0177 0.1722
Entamoeba histolytica kinesin, putative 0.0082 0.1025 0.682
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0228
Echinococcus multilocularis muscleblind protein 1 0.0153 0.2184 0.2184
Echinococcus multilocularis peregrin 0.0033 0.0215 0.0215
Echinococcus granulosus peregrin 0.0033 0.0215 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1504 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0177 0.1175
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1504 0.3174
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0177 0.1722
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1305 0.184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1305 0.184
Brugia malayi jmjC domain containing protein 0.0095 0.1231 0.1736
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0551 0.1163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0396 0.0835
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0199 0.028
Echinococcus multilocularis lamin 0.0028 0.0137 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0257 0.0297
Loa Loa (eye worm) hypothetical protein 0.0455 0.7094 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0137 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.043 0.0497
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0443 0.2943
Echinococcus granulosus muscleblind protein 0.0153 0.2184 0.2184
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1504 0.2119
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0379 0.2524
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Loa Loa (eye worm) hypothetical protein 0.0153 0.2184 0.3079
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1231 0.1231
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0157 0.0182
Brugia malayi 6-phosphofructokinase 0.0112 0.1504 0.2119
Echinococcus multilocularis kinesin family 1 0.0633 1 1
Brugia malayi jmjC domain containing protein 0.0035 0.0257 0.0362
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.1504 1
Brugia malayi PHD-finger family protein 0.0029 0.0157 0.0222
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0155 0.2213 0.3119
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0199 0.1938
Brugia malayi phosphofructokinase 0.0112 0.1504 0.2119
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1215 0.2565
Echinococcus multilocularis muscleblind protein 0.0153 0.2184 0.2184
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1504 0.2119
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1231 0.1231
Giardia lamblia PHD finger protein 15 0.0029 0.0157 0.1296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.079 0.0912
Brugia malayi 6-phosphofructokinase 0.0112 0.1504 0.2119
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1215 0.2565
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.2046 0.2362
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0674 0.2873
Brugia malayi isocitrate dehydrogenase 0.0032 0.0199 0.028
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0157 0.0222
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0157 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0674 0.2873
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1629 0.2297
Schistosoma mansoni lozenge 0.0057 0.0615 0.071
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.079 0.1667
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.043 0.043
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0157 0.1536
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0177 0.1722
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0257 0.0257
Echinococcus multilocularis Protein lozenge 0.0057 0.0615 0.0615
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0137 0.0192
Schistosoma mansoni hypothetical protein 0.0029 0.0157 0.0182
Echinococcus granulosus lamin 0.0028 0.0137 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Giardia lamblia Kinase, PLK 0.0094 0.1215 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0177 0.5
Loa Loa (eye worm) acetyltransferase 0.0145 0.2046 0.2883
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0199 0.0199
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0793 0.1117
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0198 0.0198
Mycobacterium ulcerans hypothetical protein 0.0163 0.2346 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0443 0.2943
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.1504 0.6408
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0674 0.1423
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1215 0.1712
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0199 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1504 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0379 0.3701
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.079 0.1667
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0198 0.0198
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0396 0.0835
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Plasmodium falciparum phd finger protein, putative 0.0029 0.0157 0.1536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.043 0.0497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.043 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Loa Loa (eye worm) phosphofructokinase 0.0112 0.1504 0.2119
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0199 0.0419
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0257 0.0257
Loa Loa (eye worm) kinesin-like protein KLP2 0.0082 0.1025 0.1445
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0342 0.0342
Plasmodium vivax kinesin-5 0.0082 0.1025 1
Brugia malayi Bromodomain containing protein 0.0033 0.0215 0.0303
Loa Loa (eye worm) hypothetical protein 0.0068 0.0793 0.1117
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1215 0.1215
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0396 0.0835
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.1504 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0198 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Echinococcus multilocularis lamin dm0 0.0028 0.0137 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Echinococcus granulosus GPCR family 2 0.0031 0.0198 0.0198
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1504 0.1736
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1504 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.079 0.1667
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0396 0.0835
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1215 0.155
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0157 0.1536
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0177 0.1722
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0325 0.0325
Schistosoma mansoni intermediate filament proteins 0.0028 0.0137 0.0158
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1979 0.1979
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0222
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0199 0.1938
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1504 0.3174
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0157 0.1536
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.4737 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.079 0.1113
Echinococcus granulosus intermediate filament protein 0.0028 0.0137 0.0137
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0177 0.1722
Schistosoma mansoni hypothetical protein 0.0068 0.0793 0.0915
Brugia malayi hypothetical protein 0.0155 0.2213 0.3119
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1504 0.1736
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0914 0.1055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0199 0.0199
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0199 0.0229
Schistosoma mansoni hypothetical protein 0.0164 0.2356 0.2721
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.043 0.0607
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0198 0.0198
Echinococcus multilocularis musashi 0.0028 0.0137 0.0137
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1215 0.1215
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0674 0.2873
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0199 0.028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.2076 0.4383
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1215 0.808
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0379 0.3701
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1504 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1215 0.1712
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0177 0.1454
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.1504 0.1504
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0379 0.3701
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0674 0.0674
Toxoplasma gondii hypothetical protein 0.005 0.05 0.4878
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0322 0.3137
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0322 0.2139
Loa Loa (eye worm) runx1 0.0057 0.0615 0.0867
Schistosoma mansoni lamin 0.0028 0.0137 0.0158
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.079 0.5251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.043 0.043
Echinococcus granulosus geminin 0.0164 0.2356 0.2356
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0198 0.0279
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0198 0.0279
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0674 0.6575
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1504 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0342 0.0342
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0199 0.1938
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0199 0.0419
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1215 0.1403
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0199 0.1938
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0137 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0228
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0177 0.1175
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0379 0.2524
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0674 0.0778
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.1504 0.3174
Echinococcus multilocularis geminin 0.0164 0.2356 0.2356
Plasmodium falciparum kinesin-5 0.0082 0.1025 1
Toxoplasma gondii kinesin motor domain-containing protein 0.0082 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0198 0.0279
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1215 0.2565
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0199 0.0419
Schistosoma mansoni kinase 0.0048 0.0463 0.0534
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.079 0.079
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.2076 0.4383
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.079 0.1667
Schistosoma mansoni hypothetical protein 0.0164 0.2356 0.2721
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0177 0.1175
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0674 0.0674
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.2046 0.2046

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 12.5 mm Antimicrobial activity against Candida albicans NCIM 3102 assessed as diameter of growth inhibition zone at 100 ug/ml after 48 hr by paper disk diffusion method ChEMBL. No reference
IZ (functional) = 15 mm Antimicrobial activity against Escherichia coli NCIM 2574 assessed as diameter of growth inhibition zone at 100 ug/ml after 24 hr by paper disk diffusion method ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Antimicrobial activity against Candida albicans NCIM 3102 assessed as growth inhibition by agar streak dilution method ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Antimicrobial activity against Escherichia coli NCIM 2574 assessed as growth inhibition by agar streak dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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