Detailed information for compound 1800783

Basic information

Technical information
  • TDR Targets ID: 1800783
  • Name: Methyl 2-hydroxy-3-methoxybenzoate
  • MW: 182.173 | Formula: C9H10O4
  • H donors: 1 H acceptors: 2 LogP: 1.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cccc(c1O)OC
  • InChi: 1S/C9H10O4/c1-12-7-5-3-4-6(8(7)10)9(11)13-2/h3-5,10H,1-2H3
  • InChiKey: BWRCJLJJIXYLNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-hydroxy-3-methoxy-benzoate
  • 2-hydroxy-3-methoxybenzoic acid methyl ester
  • 2-hydroxy-3-methoxy-benzoic acid methyl ester
  • 6342-70-7
  • NSC46637
  • InChI=1/C9H10O4/c1-12-7-5-3-4-6(8(7)10)9(11)13-2/h3-5,10H,1-2H
  • 449490_ALDRICH
  • EINECS 228-737-5
  • Methyl 3-methoxysalicylate
  • 2-hydroxy-3-methoxy benzoic acid methyl ester
  • ghl.PD_Mitscher_leg0.1019

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.423
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.174 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0071 0.5
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0073 0.4406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Echinococcus granulosus transcription factor btf3 0.0033 0.016 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.016 1
Schistosoma mansoni hypothetical protein 0.174 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0059 0.6071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0092
Schistosoma mansoni hypothetical protein 0.0162 0.0902 0.0897
Mycobacterium ulcerans hypothetical protein 0.0023 0.0098 1
Loa Loa (eye worm) ICD-1 protein 0.0033 0.016 0.0155
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.423
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.5981
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Plasmodium vivax basic transcription factor 3b, putative 0.0033 0.016 1
Echinococcus granulosus geminin 0.0162 0.0902 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.2267
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0098 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0005 0.0546
Leishmania major DNA polymerase eta, putative 0.0018 0.0073 0.4406
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0073 0.0068
Toxoplasma gondii exonuclease III APE 0.0018 0.0071 0.423
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.016 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.5981
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0005 0.0546
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0065
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0005 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0073 0.7367
Echinococcus multilocularis transcription factor btf3 0.0033 0.016 0.0155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0071 0.0065
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0073 0.7511
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0073 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0098 0.5981
Schistosoma mansoni hypothetical protein 0.174 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Schistosoma mansoni transcription factor btf3 0.0033 0.016 0.0155
Echinococcus granulosus dna polymerase kappa 0.0018 0.0073 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0098 0.5981
Schistosoma mansoni hypothetical protein 0.0162 0.0902 0.0897
Entamoeba histolytica hypothetical protein 0.0033 0.016 1
Echinococcus granulosus dna polymerase eta 0.0018 0.0073 0.0068
Echinococcus multilocularis dna polymerase eta 0.0018 0.0073 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.423
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0071 0.7073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0071 0.423
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0098 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0073 0.0068
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0005 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0219 0.0214
Echinococcus granulosus neuropeptide receptor A26 0.0442 0.2518 0.2514
Trypanosoma brucei unspecified product 0.0018 0.0073 0.4406
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0098 1
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0073 0.4406
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0071 0.0065
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0071 0.423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0219 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0071 0.7233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0098 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0005 0.0546
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.423
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0073 0.4406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0219 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0098 1
Onchocerca volvulus 0.0023 0.0098 1
Giardia lamblia DINP protein human, muc B family 0.0018 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0092
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0073 0.4406
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0065 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0073 0.0068
Schistosoma mansoni DNA polymerase eta 0.0018 0.0073 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0219 0.0214
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0005 0.0546
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0065
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0073 0.4406
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0219 0.0214
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0005 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0059 0.6071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0073 0.0068
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0073 0.4406
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0005 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.016 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0071 0.0065
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0071 0.5
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0073 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0059 0.6071
Brugia malayi beta-NAC-like protein 0.0033 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0068
Leishmania major DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0005 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0219 0.0214
Echinococcus multilocularis neuropeptide receptor A26 0.0442 0.2518 0.2514
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0073 0.7367
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0098 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Toxoplasma gondii NAC domain-containing protein 0.0033 0.016 1
Trypanosoma brucei unspecified product 0.0013 0.004 0.2267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0219 0.0214
Trypanosoma brucei unspecified product 0.0013 0.004 0.2267
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Trypanosoma brucei transcription factor BTF3, putative 0.0033 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.423
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0098 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.2267
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0073 0.4406
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.423
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.174 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0098 0.5981
Echinococcus granulosus neuropeptide s receptor 0.0442 0.2518 0.2514
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0065 0.384
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0073 0.4406
Echinococcus multilocularis geminin 0.0162 0.0902 0.0897
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0073 0.0068
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0065 0.6617
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 1
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.174 1 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0005 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.2267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0092
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0071 0.0065
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0065 0.384
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0073 0.4406
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0059
Trypanosoma cruzi transcription factor btf3, putative 0.0033 0.016 1
Entamoeba histolytica transcription factor BTF3, putative 0.0033 0.016 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0073 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0059 0.6071
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Plasmodium falciparum basic transcription factor 3b, putative 0.0033 0.016 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0071 0.423
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0219 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0073 0.4406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0219 0.0214
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0065 0.6421
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.5981
Loa Loa (eye worm) hypothetical protein 0.0017 0.0065 0.0059
Trypanosoma cruzi transcription factor btf3, putative 0.0033 0.016 1
Leishmania major basic transcription factor 3a, putative 0.0033 0.016 1
Echinococcus multilocularis neuropeptide s receptor 0.0442 0.2518 0.2514
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0098 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0005 0.0546
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0073 0.7511

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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