TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.481 | Formula: C25H23N5O5
H donors: 1 H acceptors: 6 LogP: 2.64 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c(O)n(C)c(=O)n(c1=O)C)/C=C/c1ccc(cc1)OCc1nnn(c1)Cc1ccccc1
InChi: 1S/C25H23N5O5/c1-28-23(32)22(24(33)29(2)25(28)34)21(31)13-10-17-8-11-20(12-9-17)35-16-19-15-30(27-26-19)14-18-6-4-3-5-7-18/h3-13,15,32H,14,16H2,1-2H3/b13-10+
InChiKey: YZHSUCHELWVVRF-JLHYYAGUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Trypanosoma brucei	multidrug resistance protein E	0.0022	0.0263	0.0263
Leishmania major	p-glycoprotein	0.0038	0.0753	0.0753
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0038	0.0753	0.0753
Entamoeba histolytica	P-glycoprotein-1	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase	0.0339	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0038	0.0753	0.0753
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0098	0.2597	0.2597
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0098	0.2597	0.2597
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0038	0.0753	0.0753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0098	0.2597	0.2597
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0753	0.0753
Trichomonas vaginalis	abcb9, putative	0.0038	0.0753	0.0753
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0022	0.0263	0.0263
Brugia malayi	ABC transporter family protein	0.0038	0.0753	0.0753
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0098	0.2597	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.0345	0.0345
Trichomonas vaginalis	taga, putative	0.0038	0.0753	0.0753
Mycobacterium tuberculosis	Probable oxidoreductase	0.0339	1	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0038	0.0753	0.2899
Trypanosoma brucei	aldo-keto reductase, putative	0.0339	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0339	1	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0339	1	1
Onchocerca volvulus		0.0339	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0038	0.0753	0.0753
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0339	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Toxoplasma gondii	aldose reductase, putative	0.0339	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0038	0.0753	0.5
Loa Loa (eye worm)	oxidoreductase	0.0339	1	1
Echinococcus granulosus	aldehyde reductase	0.0241	0.6981	0.6981
Onchocerca volvulus		0.0339	1	1
Brugia malayi	NADH-dependent xylose reductase	0.0098	0.2597	0.2597
Trichomonas vaginalis	aldo/keto reductase, putative	0.0339	1	1
Onchocerca volvulus		0.0339	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0022	0.0263	0.0263
Echinococcus multilocularis	multidrug resistance protein 1	0.0038	0.0753	0.0753
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0263	0.0263
Leishmania major	ABC-thiol transporter	0.0022	0.0263	0.0263
Echinococcus multilocularis	multidrug resistance protein 1	0.0038	0.0753	0.0753
Echinococcus granulosus	multidrug resistance associated protein 1	0.0022	0.0263	0.0263
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0098	0.2597	0.2597
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0022	0.0263	0.0263
Entamoeba histolytica	aldose reductase, putative	0.0339	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0241	0.6981	0.6981
Echinococcus multilocularis	aldehyde reductase	0.0241	0.6981	0.6981
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Onchocerca volvulus		0.0098	0.2597	0.1994
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0038	0.0753	0.0753
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0038	0.0753	0.0753
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0263	0.0263
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0014	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Loa Loa (eye worm)	oxidoreductase	0.0339	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0038	0.0753	0.0753
Trypanosoma cruzi	aldo/keto reductase, putative	0.0339	1	1
Schistosoma mansoni	multidrug resistance protein	0.0038	0.0753	0.0753
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0038	0.0753	0.0753
Trichomonas vaginalis	aldo-keto reductase, putative	0.0098	0.2597	0.2597
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0098	0.2597	0.2597
Schistosoma mansoni	potassium channel beta	0.0098	0.2597	0.2597
Echinococcus granulosus	aldo keto reductase	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Leishmania major	aldo-keto reductase-like protein	0.0339	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0022	0.0263	0.0263
Mycobacterium ulcerans	hypothetical protein	0.0098	0.2597	0.2597
Echinococcus multilocularis	aldo keto reductase	0.0339	1	1
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0098	0.2597	0.2597
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0022	0.0263	0.0263
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0098	0.2597	0.2597
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0022	0.0263	0.0263
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0038	0.0753	0.0753
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0038	0.0753	0.0753
Giardia lamblia	Aldose reductase	0.0339	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0038	0.0753	0.0753
Entamoeba histolytica	P-glycoprotein-2	0.0038	0.0753	0.0753
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0038	0.0753	0.0753
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0014	0	0.5
Trypanosoma brucei	aldo/keto reductase, putative	0.0098	0.2597	0.2597
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0038	0.0753	0.0753
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0038	0.0753	0.0753
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0022	0.0263	0.0263
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0022	0.0263	0.0263
Trichomonas vaginalis	aldo-keto reductase, putative	0.0098	0.2597	0.2597
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Echinococcus granulosus	multidrug resistance associated protein 7	0.0022	0.0263	0.0263
Onchocerca volvulus		0.0339	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0022	0.0263	0.0263
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0038	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0263	0.0263
Giardia lamblia	MRP-like ABC transporter	0.0022	0.0263	0.0015
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0339	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0339	1	1
Echinococcus multilocularis	aldo keto reductase	0.0339	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Loa Loa (eye worm)	oxidoreductase	0.0339	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0022	0.0263	0.0263
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0098	0.2597	0.2597
Entamoeba histolytica	hypothetical protein	0.0022	0.0263	0.0263
Schistosoma mansoni	aldo-keto reductase	0.0339	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0339	1	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0022	0.0263	0.0263
Trypanosoma brucei	p-glycoprotein	0.0022	0.0263	0.0263
Echinococcus granulosus	hypothetical protein	0.0339	1	1
Toxoplasma gondii	aldo-keto reductase	0.0098	0.2597	0.2597
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0098	0.2597	0.2597
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0022	0.0263	0.0263
Plasmodium falciparum	aldehyde reductase, putative	0.0098	0.2597	1
Echinococcus granulosus	aldo keto reductase	0.0339	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0038	0.0753	0.0753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Brugia malayi	multidrug resistance related protein 1	0.0022	0.0263	0.0263
Schistosoma mansoni	multidrug resistance protein	0.0038	0.0753	0.0753
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0038	0.0738	0.0738
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0339	1	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0098	0.2597	0.2597
Giardia lamblia	Multidrug resistance-associated protein 1	0.0022	0.0263	0.0015
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Onchocerca volvulus		0.0339	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0038	0.0753	0.0753
Giardia lamblia	Multidrug resistance-associated protein 1	0.0022	0.0263	0.0015
Trichomonas vaginalis	abcb9, putative	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0753	0.0753
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0038	0.0753	0.0753
Trichomonas vaginalis	ABC transporter, putative	0.0038	0.0753	0.0753
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0022	0.0263	0.0263
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0345	0.0345
Entamoeba histolytica	aldose reductase, putative	0.0339	1	1
Entamoeba histolytica	multidrug resistance protein, putative	0.0022	0.0263	0.0263
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0022	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0339	1	1
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0263	0.0263
Trichomonas vaginalis	aldo/keto reductase, putative	0.0339	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0098	0.2597	0.2597
Mycobacterium leprae	Possible oxidoreductase	0.0098	0.2597	0.2597
Echinococcus multilocularis	ATP binding cassette sub family B	0.0038	0.0738	0.0738
Loa Loa (eye worm)	oxidoreductase	0.0339	1	1
Echinococcus multilocularis	aldo keto reductase	0.0339	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0038	0.0753	0.0753
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0022	0.0263	0.0263
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0038	0.0753	0.0753
Entamoeba histolytica	P-glycoprotein-2	0.0038	0.0753	0.0753
Leishmania major	pentamidine resistance protein 1	0.0022	0.0263	0.0263
Echinococcus granulosus	voltage gated potassium channel subunit	0.0098	0.2597	0.2597
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	aldo/keto reductase, putative	0.0339	1	1
Leishmania major	p-glycoprotein e	0.0022	0.0263	0.0263
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Plasmodium falciparum	multidrug resistance protein 1	0.0038	0.0753	0.2899
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2597	0.2597
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0339	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0098	0.2597	1
Loa Loa (eye worm)	oxidoreductase	0.0339	1	1
Schistosoma mansoni	pol-related	0.0339	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0339	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0038	0.0753	0.0753
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0022	0.0263	0.0263
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0022	0.0263	0.0263
Entamoeba histolytica	P-glyco protein 6, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0345	0.0345
Entamoeba histolytica	ABC transporter, putative	0.0022	0.0263	0.0263
Entamoeba histolytica	aldose reductase, putative	0.0339	1	1
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0263	0.0263
Echinococcus granulosus	multidrug resistance protein 1	0.0038	0.0753	0.0753
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Giardia lamblia	Aldose reductase	0.0339	1	1
Plasmodium vivax	aldehyde reductase, putative	0.0098	0.2597	1
Echinococcus granulosus	multidrug resistance protein 1	0.0038	0.0753	0.0753
Mycobacterium ulcerans	oxidoreductase	0.0339	1	1
Mycobacterium tuberculosis	Conserved protein	0.0098	0.2597	0.2597
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Brugia malayi	multidrug resistance protein 3	0.0038	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0263	0.0263
Schistosoma mansoni	smdr2	0.0038	0.0753	0.0753
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0339	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0038	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0248	0.0248
Trichomonas vaginalis	ABC transporter, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0038	0.0753	0.0753
Schistosoma mansoni	multidrug resistance protein	0.0038	0.0753	0.0753
Schistosoma mansoni	aldo-keto reductase	0.0339	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0339	1	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0038	0.0753	0.0753
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0339	1	1
Echinococcus granulosus	aldo keto reductase	0.0339	1	1
Onchocerca volvulus		0.0339	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0339	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0022	0.0263	0.0263
Entamoeba histolytica	P-glycoprotein-5	0.0038	0.0753	0.0753
Trichomonas vaginalis	aldo-keto reductase, putative	0.0098	0.2597	0.2597
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0038	0.0753	0.0753
Entamoeba histolytica	P-glycoprotein-2, putative	0.0038	0.0753	0.0753
Trichomonas vaginalis	abcb9, putative	0.0038	0.0753	0.0753
Leishmania major	prostaglandin f synthase, putative	0.0339	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0339	1	1
Giardia lamblia	ABC transporter, putative	0.0022	0.0263	0.0015
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0345	0.0345

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 0 mm	Antibacterial activity against Escherichia coli DH5[alpha] at 5 mg/ml after 24 hrs by Kirby-Bauer single disc susceptibility test	ChEMBL.	No reference
IZ (functional)	= 0 mm	Antibacterial activity against Escherichia coli DH5[alpha] at 2.5 mg/ml after 24 hrs by Kirby-Bauer single disc susceptibility test	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2281904

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1801501