Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bombyx mori | Ecdysone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0025 | 0.0667 | 0.0992 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.6726 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0617 | 0.0917 |
Schistosoma mansoni | serine/threonine kinase | 0.0025 | 0.0667 | 0.0992 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0025 | 0.0667 | 0.0667 |
Plasmodium falciparum | MO15-related protein kinase | 0.0025 | 0.0667 | 0.5 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0106 | 0.5091 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.5091 | 0.757 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0137 | 0.6726 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0025 | 0.0667 | 0.0667 |
Echinococcus granulosus | dual specificity | 0.0106 | 0.5091 | 0.757 |
Echinococcus granulosus | dual specificity | 0.0106 | 0.5091 | 0.757 |
Echinococcus granulosus | Pfam-B_8186 domain containing protein | 0.0024 | 0.0617 | 0.0917 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0025 | 0.0667 | 0.0111 |
Echinococcus multilocularis | dual specificity | 0.0106 | 0.5091 | 0.757 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0106 | 0.5091 | 0.5091 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0025 | 0.0667 | 0.0992 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.0667 | 0.0992 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0106 | 0.5091 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0025 | 0.0667 | 0.0667 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0025 | 0.0667 | 0.0992 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0025 | 0.0667 | 0.0992 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0106 | 0.5091 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0106 | 0.5091 | 1 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0025 | 0.0667 | 0.0992 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0025 | 0.0667 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0106 | 0.5091 | 0.5091 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0137 | 0.6726 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0137 | 0.6726 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0024 | 0.0617 | 0.0917 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0025 | 0.0667 | 0.0111 |
Brugia malayi | hypothetical protein | 0.0137 | 0.6726 | 0.6726 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0025 | 0.0667 | 0.0992 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0025 | 0.0667 | 0.5 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0106 | 0.5091 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.0667 | 0.0667 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0025 | 0.0667 | 0.0992 |
Loa Loa (eye worm) | haspin protein kinase | 0.0137 | 0.6726 | 0.6726 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0025 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | haspin protein kinase | 0.0138 | 0.6775 | 0.6775 |
Loa Loa (eye worm) | haspin protein kinase | 0.0137 | 0.6726 | 0.6726 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0137 | 0.6726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0137 | 0.6726 | 1 |
Echinococcus multilocularis | dual specificity | 0.0106 | 0.5091 | 0.757 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0197 | 1 | 1 |
Brugia malayi | GSG2 | 0.0137 | 0.6726 | 0.6726 |
Echinococcus multilocularis | dual specificity | 0.0106 | 0.5091 | 0.757 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.5091 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0106 | 0.5091 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0106 | 0.5091 | 0.757 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0106 | 0.5091 | 1 |
Schistosoma mansoni | protein kinase | 0.0025 | 0.0667 | 0.0992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 4 | Agonist activity at ecdysone receptor in Drosophila melanogaster S2 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20672340 |
EC50 (binding) | = 7.1 | Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20672340 |
Efficacy (binding) | = 36 % | Agonist activity at ecdysone receptor in Drosophila melanogaster S2 cells at 100 uM after 24 hr by luciferase reporter gene assay relative to 20-hydroxyecdysone | ChEMBL. | 20672340 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.