Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0391 | 0.5156 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0301 | 0.04 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1407 | 0.204 |
Schistosoma mansoni | protein kinase | 0.0091 | 0.0805 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.05 | 0.674 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1407 | 0.2031 |
Entamoeba histolytica | chitinase, putative | 0.0081 | 0.0652 | 0.0882 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Mycobacterium tuberculosis | Possible chitinase | 0.0069 | 0.0479 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0091 | 0.0805 | 0.0078 |
Loa Loa (eye worm) | haspin protein kinase | 0.05 | 0.674 | 0.9894 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0091 | 0.0805 | 0.0078 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0144 | 0.1565 | 0.0897 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0069 | 0.0479 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0391 | 0.5156 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0301 | 0.04 |
Plasmodium falciparum | conserved protein, unknown function | 0.0128 | 0.1342 | 0.8548 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0091 | 0.0805 | 0.0078 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0144 | 0.1565 | 0.0897 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0144 | 0.1565 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1342 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1019 | 0.1457 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0888 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0128 | 0.1342 | 0.1942 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Loa Loa (eye worm) | haspin protein kinase | 0.05 | 0.674 | 0.9894 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1493 | 0.2157 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0038 | 0.003 | 0.5 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0091 | 0.0805 | 0.1191 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0144 | 0.1565 | 0.1746 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Onchocerca volvulus | 0.0106 | 0.1019 | 0.7125 | |
Brugia malayi | hypothetical protein | 0.05 | 0.674 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0091 | 0.0805 | 0.0078 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133 | 0.1407 | 0.0727 |
Loa Loa (eye worm) | chitinase I | 0.0081 | 0.0652 | 0.0917 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0128 | 0.1342 | 0.0657 |
Onchocerca volvulus | 0.0128 | 0.1342 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0079 | 0.0621 | 0.0871 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0479 | 0.0662 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0091 | 0.0805 | 0.0078 |
Brugia malayi | Protein kinase domain containing protein | 0.0144 | 0.1565 | 0.2275 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0051 | 0.0217 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.0144 | 0.1565 | 0.1746 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0091 | 0.0805 | 0.505 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0733 | 0.1034 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.0652 | 0.3871 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0391 | 0.5156 | 0.7635 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0301 | 0.0389 |
Brugia malayi | GSG2 | 0.05 | 0.674 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0144 | 0.1565 | 0.1746 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0144 | 0.1565 | 0.2263 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1407 | 0.2031 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133 | 0.1407 | 0.2031 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 0.096 | 0.1505 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0144 | 0.1565 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.096 | 0.1372 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Brugia malayi | endochitinase | 0.0091 | 0.0794 | 0.1124 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Loa Loa (eye worm) | haspin protein kinase | 0.0505 | 0.6812 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Mycobacterium ulcerans | hypothetical protein | 0.0051 | 0.0217 | 0.4154 |
Echinococcus multilocularis | tumor protein p63 | 0.0724 | 1 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0128 | 0.1342 | 0.0657 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0301 | 0.0389 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0069 | 0.0479 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0091 | 0.0805 | 0.1143 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0091 | 0.0805 | 0.505 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.1565 | 0.2275 |
Leishmania major | chitinase | 0.0081 | 0.0652 | 0.0882 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0051 | 0.0217 | 0.4521 |
Leishmania major | protein kinase, putative | 0.0144 | 0.1565 | 0.2729 |
Entamoeba histolytica | protein kinase, putative | 0.0391 | 0.5156 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0102 | 0.096 | 0.1371 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.0652 | 0.3871 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.1407 | 0.2031 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0144 | 0.1565 | 0.1746 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0102 | 0.096 | 0.1505 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0091 | 0.0805 | 0.1191 |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.096 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Echinococcus granulosus | dual specificity | 0.0102 | 0.096 | 0.0245 |
Echinococcus granulosus | hypothetical protein | 0.0139 | 0.1493 | 0.082 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0091 | 0.0805 | 0.0078 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0106 | 0.1019 | 0.1459 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0038 | 0.003 | 0.0628 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0144 | 0.1565 | 0.1746 |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0051 | 0.0217 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0391 | 0.5156 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.1407 | 0.204 |
Brugia malayi | Cell division protein kinase 2 | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0391 | 0.5156 | 0.7558 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0091 | 0.0805 | 0.1191 |
Brugia malayi | Endochitinase | 0.0091 | 0.0794 | 0.1124 |
Plasmodium vivax | hypothetical protein, conserved | 0.0128 | 0.1342 | 0.8548 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0391 | 0.5156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0888 | 0.1265 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0091 | 0.0805 | 0.0078 |
Leishmania major | protein kinase, putative | 0.0144 | 0.1565 | 0.2729 |
Onchocerca volvulus | 0.0128 | 0.1342 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Plasmodium falciparum | MO15-related protein kinase | 0.0091 | 0.0805 | 0.505 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.1342 | 0.1942 |
Brugia malayi | endochitinase | 0.0081 | 0.0652 | 0.0913 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Echinococcus multilocularis | dual specificity | 0.0102 | 0.096 | 0.0245 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.1565 | 0.2275 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0144 | 0.1565 | 0.1746 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0144 | 0.1565 | 0.1746 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0391 | 0.5156 | 0.7635 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0144 | 0.1565 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0091 | 0.0805 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0041 | 0.0016 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0051 | 0.0217 | 0.4521 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1342 | 0.1934 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.0805 | 0.1191 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1407 | 0.204 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0391 | 0.5156 | 1 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0391 | 0.5156 | 1 |
Echinococcus multilocularis | 0.0139 | 0.1493 | 0.082 | |
Entamoeba histolytica | hypothetical protein | 0.0086 | 0.0733 | 0.1046 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0081 | 0.0652 | 0.0917 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0144 | 0.1565 | 0.1746 |
Schistosoma mansoni | serine/threonine kinase | 0.0091 | 0.0805 | 0.1141 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133 | 0.1407 | 0.0727 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
log(1/I50) (binding) | = 8.22 | Inhibition of susceptible Nephotettix cincticeps Izumi (green rice leafhopper) acetylcholinesterase activity | ChEMBL. | No reference |
log(1/I50) (binding) | = 8.8 | Inhibition of susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase activity | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.