Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Gamma-amino-N-butyrate transaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium ulcerans | L-lysine aminotransferase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes similar to S. cerevisiae UGA1 (YGR019W) gamma-aminobutyrate (GABA) transaminase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.005 | 0.1122 | 0.0781 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0387 | 0.0444 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.005 | 0.1122 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0387 | 0.3449 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.005 | 0.1122 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0387 | 0.0444 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0026 | 0.0371 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0026 | 0.0371 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0387 | 0.0017 |
Schistosoma mansoni | lamin | 0.0027 | 0.0387 | 0.0219 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0026 | 0.0371 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0026 | 0.0371 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0372 | 0.3313 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.1122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1082 | 0.9643 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0387 | 0.3449 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0387 | 0.0017 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.1122 | 0.1287 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.1122 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0387 | 0.0017 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0387 | 0.0017 |
Schistosoma mansoni | lamin | 0.0027 | 0.0387 | 0.0219 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.1122 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.1122 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0026 | 0.0371 | 0.5 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0293 | 0.8723 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0387 | 0.3449 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0293 | 0.8723 | 1 |
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0026 | 0.0371 | 0.5 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0026 | 0.0371 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0387 | 0.0017 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.1082 | 0.9468 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.005 | 0.1122 | 0.0781 |
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0026 | 0.0371 | 0.5 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0293 | 0.8723 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.1122 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0334 | 1 | 1 |
Onchocerca volvulus | 0.0049 | 0.1082 | 1 | |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0387 | 0.0219 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0026 | 0.0371 | 0.5 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.005 | 0.1122 | 0.1287 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0387 | 0.0017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NADPH generation after 30 min by spectrophotometric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.