Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth hormone secretagogue receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | growth hormone secretagogue receptor | 289 aa | 243 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0031 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0022 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0011 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0033 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | fatty acid synthase | 0.0033 | 0.4277 | 0.4318 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0036 | 0.4752 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0024 | 0.2547 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0028 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.005 | 0.7476 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0036 | 0.4752 | 0.6357 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0036 | 0.4752 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0027 | 0.3131 | 0.4155 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0033 | 0.4361 | 0.4361 |
Brugia malayi | AMP-binding enzyme family protein | 0.0031 | 0.3948 | 0.3948 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.005 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0027 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0036 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.0058 | 0.9025 | 0.9285 | |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0036 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.8643 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0033 | 0.4361 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0022 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0028 | 0.3311 | 0.443 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0022 | 0.2149 | 0.2574 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0019 | 0.1644 | 0.2199 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0027 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | polyketide synthase | 0.0036 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0022 | 0.2228 | 0.2941 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0036 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.005 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0027 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0024 | 0.2588 | 0.3461 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0033 | 0.4361 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0036 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0028 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0031 | 0.3948 | 0.528 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0011 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0032 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | thioesterase TesA | 0.0028 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.005 | 0.7476 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0011 | 0.0229 | 0.0306 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.006 | 0.9416 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0036 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0032 | 0.4168 | 0.5576 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.4752 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0033 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0014 | 0.061 | 0.0817 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 uM | Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells | ChEMBL. | 14698149 |
IC50 (binding) | = 15 uM | Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells | ChEMBL. | 14698149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.