Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone deacetylase hda2 | 0.0384 | 0.0726 | 0.0724 |
Schistosoma mansoni | tyrosine kinase | 0.1488 | 0.3136 | 0.3135 |
Echinococcus granulosus | activin receptor type | 0.0068 | 0.0038 | 0.0037 |
Brugia malayi | Protein kinase domain containing protein | 0.0426 | 0.0819 | 0.0818 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.079 | 0.1612 | 0.161 |
Schistosoma mansoni | tyrosine kinase | 0.2458 | 0.5252 | 0.525 |
Trypanosoma brucei | histone deacetylase 1 | 0.0907 | 0.1868 | 0.2513 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3405 | 0.7319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.008 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0081 | 0.008 |
Echinococcus granulosus | epidermal growth factor receptor | 0.4634 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2209 | 0.4709 | 0.4709 |
Schistosoma mansoni | vesicular amine transporter | 0.0055 | 0.001 | 0.0007 |
Schistosoma mansoni | tyrosine kinase | 0.2495 | 0.5333 | 0.5332 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0907 | 0.1868 | 0.1867 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0024 | 0.0023 |
Echinococcus granulosus | Immunoglobulin | 0.0055 | 0.001 | 0.0009 |
Plasmodium falciparum | histone deacetylase 2 | 0.079 | 0.1612 | 0.8603 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0931 | 0.192 | 0.1919 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3405 | 0.7319 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1495 | 0.3151 | 0.315 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3405 | 0.7319 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0068 | 0.0038 | 0.0037 |
Trypanosoma cruzi | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Echinococcus granulosus | histone deacetylase 1 | 0.0907 | 0.1868 | 0.1867 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0055 | 0.001 | 0.0009 |
Echinococcus multilocularis | titin | 0.0052 | 0.0002 | 0.0001 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3405 | 0.7319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0024 | 0.0023 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0055 | 0.001 | 0.0007 |
Brugia malayi | histone deacetylase 11 | 0.0384 | 0.0726 | 0.0725 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.007 | 0.0042 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.2495 | 0.5333 | 0.5332 |
Leishmania major | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0822 | 0.1682 | 0.2257 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 0.1868 | 0.1867 |
Trypanosoma brucei | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Brugia malayi | Histone deacetylase 1 | 0.0907 | 0.1868 | 0.1867 |
Echinococcus granulosus | neuroglian | 0.0069 | 0.0041 | 0.0039 |
Onchocerca volvulus | 0.0173 | 0.0267 | 0.148 | |
Brugia malayi | protein unc-22 | 0.0052 | 0.0002 | 0.0001 |
Plasmodium falciparum | histone deacetylase 1 | 0.0907 | 0.1868 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2209 | 0.4709 | 0.6415 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.0775 | 0.0774 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0062 | 0.0024 | 0.0023 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0426 | 0.0819 | 0.0818 |
Plasmodium falciparum | histone deacetylase, putative | 0.079 | 0.1612 | 0.8603 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2209 | 0.4709 | 0.6415 |
Echinococcus multilocularis | histone deacetylase 6 | 0.079 | 0.1612 | 0.1611 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.1488 | 0.3136 | 0.3136 |
Brugia malayi | MAP kinase sur-1 | 0.3405 | 0.7319 | 0.7319 |
Schistosoma mansoni | tyrosine kinase | 0.1488 | 0.3136 | 0.3135 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0384 | 0.0726 | 0.0944 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0384 | 0.0726 | 0.0944 |
Leishmania major | histone deacetylase, putative | 0.0907 | 0.1868 | 0.2513 |
Echinococcus multilocularis | insulin receptor | 0.1488 | 0.3136 | 0.3136 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0384 | 0.0726 | 0.0725 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3405 | 0.7319 | 0.7319 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3405 | 0.7319 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3405 | 0.7319 | 1 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0068 | 0.0038 | 0.0037 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.4634 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3405 | 0.7319 | 0.7319 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0068 | 0.0038 | 0.0037 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3405 | 0.7319 | 1 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.0038 | 0.0036 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0907 | 0.1868 | 0.1867 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0907 | 0.1868 | 0.1867 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0073 | 0.0049 | 0.0048 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3405 | 0.7319 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0808 | 0.1652 | 0.1651 |
Echinococcus granulosus | histone deacetylase | 0.079 | 0.1612 | 0.1611 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0907 | 0.1868 | 0.1867 |
Trypanosoma brucei | protein kinase, putative | 0.3405 | 0.7319 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0808 | 0.1652 | 0.1651 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.021 | 0.0348 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0154 | 0.0153 |
Echinococcus multilocularis | histone deacetylase 6 | 0.079 | 0.1612 | 0.1611 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3405 | 0.7319 | 1 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.0038 | 0.0036 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0822 | 0.1682 | 0.2257 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0907 | 0.1868 | 0.1867 |
Echinococcus granulosus | roundabout 2 | 0.0094 | 0.0094 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.001 | 0.0009 |
Brugia malayi | Protein kinase domain containing protein | 0.1488 | 0.3136 | 0.3136 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.0258 | 0.0452 | 0.0451 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3405 | 0.7319 | 0.7319 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.0154 | 0.0847 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2209 | 0.4709 | 0.4709 |
Echinococcus multilocularis | neuroglian | 0.0069 | 0.0041 | 0.0039 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3405 | 0.7319 | 0.7319 |
Plasmodium vivax | histone deacetylase 2, putative | 0.079 | 0.1612 | 0.8631 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0931 | 0.192 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.001 | 0.0009 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.4634 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0384 | 0.0726 | 0.0725 |
Echinococcus granulosus | twitchin | 0.0101 | 0.0109 | 0.0108 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0052 | 0.0002 | 0.0001 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2209 | 0.4709 | 0.6415 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0024 | 0.0023 |
Echinococcus multilocularis | 0.1431 | 0.3011 | 0.301 | |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0907 | 0.1868 | 0.1867 |
Brugia malayi | Histone deacetylase family protein | 0.079 | 0.1612 | 0.1611 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.021 | 0.0348 | 0.0347 |
Trypanosoma cruzi | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0055 | 0.001 | 0.0007 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3405 | 0.7319 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2209 | 0.4709 | 0.4708 |
Schistosoma mansoni | ephrin receptor | 0.021 | 0.0348 | 0.0346 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.079 | 0.1612 | 0.2162 |
Echinococcus multilocularis | histone deacetylase | 0.079 | 0.1612 | 0.1611 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.0815 | 0.0814 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0074 | 0.0051 | 0.005 |
Plasmodium vivax | histone deacetylase, putative | 0.079 | 0.1612 | 0.8631 |
Leishmania major | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0803 | 0.1642 | 0.1641 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2209 | 0.4709 | 0.6415 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3405 | 0.7319 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.4634 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2495 | 0.5333 | 0.5332 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0907 | 0.1868 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.079 | 0.1612 | 0.1611 |
Trypanosoma brucei | histone deacetylase 4 | 0.079 | 0.1612 | 0.2162 |
Schistosoma mansoni | tyrosine kinase | 0.0069 | 0.004 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0024 | 0.0023 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0052 | 0.0002 | 0.0001 |
Echinococcus granulosus | insulin receptor | 0.1488 | 0.3136 | 0.3136 |
Trypanosoma brucei | histone deacetylase 2 | 0.0384 | 0.0726 | 0.0944 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0384 | 0.0726 | 0.0944 |
Brugia malayi | ephrin receptor 1 precursor | 0.0119 | 0.0148 | 0.0147 |
Schistosoma mansoni | tyrosine kinase | 0.2458 | 0.5252 | 0.525 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0808 | 0.1652 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0154 | 0.0153 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0822 | 0.1682 | 0.2257 |
Schistosoma mansoni | cell adhesion molecule | 0.008 | 0.0063 | 0.0061 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0052 | 0.0002 | 0.0001 |
Echinococcus granulosus | defective proboscis extension response | 0.0055 | 0.001 | 0.0009 |
Echinococcus multilocularis | Immunoglobulin | 0.0055 | 0.001 | 0.0009 |
Echinococcus multilocularis | Immunoglobulin | 0.0055 | 0.001 | 0.0009 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3405 | 0.7319 | 0.7319 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2495 | 0.5333 | 0.5332 |
Brugia malayi | Histone deacetylase family protein | 0.079 | 0.1612 | 0.1611 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0872 | 0.1791 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0384 | 0.0726 | 0.3886 |
Echinococcus granulosus | titin | 0.0052 | 0.0002 | 0.0001 |
Echinococcus multilocularis | roundabout 2 | 0.0094 | 0.0094 | 0.0093 |
Echinococcus granulosus | titin | 0.0052 | 0.0002 | 0.0001 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0907 | 0.1868 | 0.2513 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.1495 | 0.3151 | 0.315 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.008 | 0.0079 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3405 | 0.7319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0049 | 0.0048 |
Leishmania major | histone deacetylase, putative | 0.0907 | 0.1868 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.0726 | 0.0725 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.079 | 0.1612 | 0.1611 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.079 | 0.1612 | 0.161 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.2209 | 0.4709 | 0.4709 |
Echinococcus multilocularis | histone deacetylase 7 | 0.079 | 0.1612 | 0.1611 |
Schistosoma mansoni | tyrosine kinase | 0.2458 | 0.5252 | 0.525 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0154 | 0.0153 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3405 | 0.7319 | 0.7319 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0267 | 0.0266 |
Echinococcus granulosus | histone deacetylase 7 | 0.079 | 0.1612 | 0.1611 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.001 | 0.0009 |
Schistosoma mansoni | histone deacetylase | 0.0907 | 0.1868 | 0.1866 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.0154 | 0.0847 |
Echinococcus granulosus | histone deacetylase 6 | 0.079 | 0.1612 | 0.1611 |
Echinococcus granulosus | histone deacetylase 3 | 0.0907 | 0.1868 | 0.1867 |
Trypanosoma brucei | histone deacetylase 3 | 0.079 | 0.1612 | 0.2162 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0822 | 0.1682 | 0.2257 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3405 | 0.7319 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0907 | 0.1868 | 0.2513 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0822 | 0.1682 | 0.2257 |
Loa Loa (eye worm) | histone deacetylase | 0.079 | 0.1612 | 0.1611 |
Entamoeba histolytica | histone deacetylase, putative | 0.0907 | 0.1868 | 1 |
Onchocerca volvulus | 0.082 | 0.1679 | 0.9374 | |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0907 | 0.1868 | 0.2513 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0384 | 0.0726 | 0.4045 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0384 | 0.0726 | 0.0944 |
Schistosoma mansoni | histone deacetylase | 0.0907 | 0.1868 | 0.1866 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2209 | 0.4709 | 0.4709 |
Trypanosoma cruzi | histone deacetylase, putative | 0.079 | 0.1612 | 0.2162 |
Echinococcus granulosus | histone deacetylase 8 | 0.0384 | 0.0726 | 0.0725 |
Schistosoma mansoni | nephrin | 0.0076 | 0.0055 | 0.0052 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0384 | 0.0726 | 0.0724 |
Leishmania major | 0.2209 | 0.4709 | 0.6415 | |
Schistosoma mansoni | protein kinase | 0.0068 | 0.0038 | 0.0036 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0907 | 0.1868 | 0.2513 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0062 | 0.0024 | 0.0023 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2495 | 0.5333 | 0.5332 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 48 hr by CLSI broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hr by CLSI broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli producing extended spectrum beta lactamase enzyme after 24 hr by CLSI broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.