TDR Targets

Basic information

Technical information

TDR Targets ID: 1809647
Name: 1-[2-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy] phenyl]-3-phenylpropan-1-one
MW: 367.481 | Formula: C23H29NO3
H donors: 1 H acceptors: 2 LogP: 3.73 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H](CN1CCCCC1)COc1ccccc1C(=O)CCc1ccccc1
InChi: 1S/C23H29NO3/c25-20(17-24-15-7-2-8-16-24)18-27-23-12-6-5-11-21(23)22(26)14-13-19-9-3-1-4-10-19/h1,3-6,9-12,20,25H,2,7-8,13-18H2/t20-/m1/s1
InChiKey: DMYOHQBLOZMDLP-HXUWFJFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[2-[(2R)-2-hydroxy-3-(1-piperidyl)propoxy]phenyl]-3-phenyl-propan-1-one
1-[2-[(2R)-2-hydroxy-3-(1-piperidyl)propoxy]phenyl]-3-phenylpropan-1-one
1-[2-[(2R)-2-hydroxy-3-piperidino-propoxy]phenyl]-3-phenyl-propan-1-one
1-[2-[(2R)-2-hydroxy-3-piperidin-1-yl-propoxy]phenyl]-3-phenyl-propan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0024	0.0118	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0031	0.021	0.021
Schistosoma mansoni	hypothetical protein	0.0016	0.0009	0.0025
Echinococcus granulosus	solute carrier family 22	0.0018	0.0032	0.0089
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0039	0.0324	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Schistosoma mansoni	amine GPCR	0.0194	0.2489	0.6981
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Trypanosoma cruzi	sugar transporter, putative	0.0018	0.0032	0.0032
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.0331	0.0331
Echinococcus granulosus	g protein coupled receptor	0.0031	0.021	0.059
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	histamine h1 receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0031	0.021	0.021
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0031	0.021	0.059
Echinococcus multilocularis	orexin receptor type 2	0.0031	0.021	0.059
Echinococcus granulosus	dro:myosuppressin receptor	0.0031	0.021	0.059
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0028	0.0177	0.0177
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0031	0.021	0.021
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0024	0.0118	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.0331	0.0331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Leishmania major	glucose transporter, lmgt1	0.0039	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0331	0.1973
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.0331	0.0331
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0031	0.021	0.059
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0022	0.0085	0.0085
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0495	0.0495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0324	0.0908
Brugia malayi	Sugar transporter family protein	0.0126	0.1546	0.1546
Toxoplasma gondii	protein kinase, putative	0.0357	0.4762	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.021	0.059
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0022	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Onchocerca volvulus		0.0022	0.0085	0.2966
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0028	0.0177	1
Echinococcus multilocularis	serotonin receptor	0.0271	0.3565	1
Brugia malayi	Dopamine receptor	0.0031	0.021	0.021
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0018	0.0032	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Onchocerca volvulus		0.0022	0.0085	0.2966
Echinococcus granulosus	allatostatin A receptor	0.0031	0.021	0.059
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Echinococcus multilocularis	glycine receptor subunit beta	0.0022	0.0085	0.0238
Schistosoma mansoni	opsin-like receptor	0.0031	0.021	0.059
Schistosoma mansoni	glucose transport protein	0.0126	0.1546	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0271	0.3565	0.3565
Plasmodium falciparum	lysine--tRNA ligase	0.0028	0.0177	0.0244
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.021	0.059
Echinococcus multilocularis	solute carrier family 22	0.0018	0.0032	0.0089
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0039	0.0324	0.0446
Echinococcus multilocularis	lysyl tRNA synthetase	0.0028	0.0177	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.021	0.059
Echinococcus multilocularis	serotonin receptor	0.0271	0.3565	1
Schistosoma mansoni	protein kinase	0.0039	0.0324	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0018	0.0032	0.2696
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Entamoeba histolytica	hypothetical protein	0.0028	0.0177	0.3876
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0031	0.021	0.059
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Brugia malayi	hypothetical protein	0.0018	0.0032	0.0032
Echinococcus multilocularis	neuropeptide receptor A26	0.0031	0.021	0.059
Brugia malayi	hypothetical protein	0.0018	0.0032	0.0032
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.021	0.059
Echinococcus multilocularis	nAChR subunit	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0177	0.0177
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0039	0.0324	0.0446
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0038	0.0313	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus granulosus	calcium dependent protein kinase	0.0036	0.029	0.0814
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0039	0.0331	0.0331
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Brugia malayi	hypothetical protein	0.0032	0.023	0.023
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Chlamydia trachomatis	lysine--tRNA ligase	0.0028	0.0177	0.5
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0016	0.0001	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	sugar transporter	0.0018	0.0032	0.0032
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Schistosoma mansoni	biogenic amine receptor	0.0031	0.021	0.059
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.021	0.059
Onchocerca volvulus		0.0031	0.021	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.021	0.059
Brugia malayi	Cation transporter family protein	0.0022	0.0085	0.0085
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0022	0.0085	0.0085
Echinococcus granulosus	neuropeptide receptor A26	0.0031	0.021	0.059
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.0331	0.1973
Onchocerca volvulus		0.0031	0.021	1
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Brugia malayi	major facilitator superfamily protein	0.0018	0.0032	0.0032
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0018	0.0032	0.2696
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Brugia malayi	AKH receptor	0.0031	0.021	0.021
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0028	0.0177	0.0961
Brugia malayi	hypothetical protein	0.0049	0.0474	0.0474
Trypanosoma brucei	sugar transporter, putative	0.0018	0.0032	0.0032
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0031	0.021	0.059
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0018	0.0032	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0085	0.0085
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.021	0.059
Brugia malayi	G protein-coupled receptor F59B2.13	0.0031	0.021	0.021
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.021	0.059
Brugia malayi	Major Facilitator Superfamily protein	0.0018	0.0032	0.0032
Loa Loa (eye worm)	ACC-1 protein	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0031	0.021	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.021	0.059
Trypanosoma brucei	glucose transporter 1E	0.0039	0.0331	0.0331
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0031	0.021	0.059
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0028	0.0177	0.3046
Brugia malayi	Cation transporter family protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0031	0.021	0.059
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0044	0.04	0.04
Echinococcus multilocularis	G protein coupled receptor 139	0.0031	0.021	0.059
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0038	0.0313	0.9543
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0018	0.0032	0.0032
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0495	0.0495
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0039	0.0324	0.0446
Schistosoma mansoni	neuropeptide receptor	0.0031	0.021	0.059
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.04	0.04
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	Sugar transporter family protein	0.0018	0.0032	0.0032
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0009	0.0025
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0022	0.0085	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Schistosoma mansoni	myosin xvIII	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0022	0.0085	0.0238
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0129	0.0641
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0038	0.0313	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0022	0.0085	0.0085
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0039	0.0324	0.0446
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0009	0.0009
Schistosoma mansoni	adenoreceptor	0.0031	0.021	0.059
Leishmania major	myo-inositol/proton symporter (MIT)	0.0018	0.0032	0.0032
Brugia malayi	neuropeptide F receptor	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0732	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.0474	0.0996
Echinococcus multilocularis	neuropeptide s receptor	0.0031	0.021	0.059
Schistosoma mansoni	sugar transporter	0.0018	0.0032	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	solute carrier family 22	0.0018	0.0032	0.0089
Echinococcus granulosus	GPCR family 2	0.0016	0.0009	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus granulosus	hypothetical protein	0.0031	0.021	0.059
Echinococcus granulosus	fmrfamide receptor	0.0031	0.021	0.059
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0039	0.0324	0.0446
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0018	0.0032	0.0089
Schistosoma mansoni	opsin-like receptor	0.0031	0.021	0.059
Plasmodium falciparum	hexose transporter	0.0126	0.1546	0.2129
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0031	0.021	0.059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Echinococcus granulosus	7tm_1 domain containing protein	0.0031	0.021	0.059
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0085	0.0085
Echinococcus granulosus	neuropeptide receptor	0.0031	0.021	0.059
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.04	0.04
Brugia malayi	Major Facilitator Superfamily protein	0.0018	0.0032	0.0032
Echinococcus multilocularis	General substrate transporter	0.0108	0.1298	0.3641
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0039	0.0324	0.0446
Onchocerca volvulus		0.0022	0.0085	0.2966
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.021	0.059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0271	0.3565	1
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Plasmodium falciparum	protein kinase 6	0.0536	0.7262	1
Brugia malayi	sulfakinin receptor protein	0.0031	0.021	0.021
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0031	0.021	0.021
Toxoplasma gondii	sugar transporter ST3	0.0018	0.0032	0.0067
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0031	0.021	0.059
Echinococcus granulosus	g-protein coupled receptor	0.0031	0.021	0.059
Brugia malayi	G-protein coupled receptor	0.0031	0.021	0.021
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	lysyl-tRNA synthetase	0.0028	0.0177	0.0497
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0031	0.021	0.021
Brugia malayi	major facilitator superfamily protein	0.0018	0.0032	0.0032
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0038	0.0313	0.0877
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Plasmodium vivax	lysine--tRNA ligase, putative	0.0028	0.0177	0.0244
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0009	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.021	0.059
Onchocerca volvulus	Putative nachr subunit	0.0022	0.0085	0.2966
Schistosoma mansoni	protein kinase	0.0039	0.0324	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0022	0.0085	0.0238
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Trichomonas vaginalis	glucose transporter, putative	0.0039	0.0331	0.1973
Schistosoma mansoni	amine GPCR	0.0031	0.021	0.059
Schistosoma mansoni	neurotransmitter gated ion channel	0.0022	0.0085	0.0238
Onchocerca volvulus		0.0022	0.0085	0.2966
Echinococcus granulosus	solute carrier family 22	0.0018	0.0032	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	LGC-31 protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0022	0.0085	0.2966
Brugia malayi	Major Facilitator Superfamily protein	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus granulosus	neuropeptide s receptor	0.0031	0.021	0.059
Onchocerca volvulus		0.0031	0.021	1
Echinococcus multilocularis	somatostatin receptor	0.0031	0.021	0.059
Echinococcus granulosus	G protein coupled receptor 139	0.0031	0.021	0.059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	solute carrier family 22	0.0018	0.0032	0.0089
Schistosoma mansoni	biogenic amine receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0039	0.0324	0.068
Trypanosoma brucei	glucose transporter 2A	0.0039	0.0331	0.0331
Onchocerca volvulus		0.0031	0.021	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0031	0.021	1
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.021	0.059
Entamoeba histolytica	protein kinase, putative	0.0039	0.0324	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Brugia malayi	Cation transporter family protein	0.0022	0.0085	0.0085
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0028	0.0177	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.027	0.027
Onchocerca volvulus		0.0031	0.021	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0031	0.021	0.059
Echinococcus multilocularis	g-protein coupled receptor	0.0031	0.021	0.059
Schistosoma mansoni	hypothetical protein	0.0016	0.0009	0.0025
Echinococcus granulosus	neuropeptide receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.021	0.059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Leishmania major	hypothetical protein, conserved	0.0049	0.0474	0.0474
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0313	0.0313
Brugia malayi	Sugar transporter family protein	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0085	0.0085
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0031	0.021	0.059
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.021	0.059
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Schistosoma mansoni	glucose transporter	0.0018	0.0032	0.0089
Echinococcus granulosus	somatostatin receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0732	1	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0028	0.0177	0.0497
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0031	0.021	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0271	0.3565	1
Schistosoma mansoni	neuropeptide receptor	0.0031	0.021	0.059
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0031	0.021	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0009	0.0025
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0204	0.2631	0.3623
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.021	0.021
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.0331	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Onchocerca volvulus		0.0022	0.0085	0.2966
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0022	0.0085	0.2966
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0031	0.021	0.059
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0031	0.021	0.059
Schistosoma mansoni	hypothetical protein	0.0031	0.021	0.059
Onchocerca volvulus		0.0031	0.021	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0022	0.0085	0.0238
Brugia malayi	Dopamine receptor protein 1	0.0031	0.021	0.021
Brugia malayi	G protein-coupled receptor	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0374	0.5006	0.5006
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0474	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0009	0.0025
Toxoplasma gondii	sugar transporter ST2	0.0018	0.0032	0.0067
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.021	0.059
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0474	0.0474
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.0331	0.0331
Brugia malayi	putative neuropeptide receptor	0.0031	0.021	0.021
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.021	0.059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.021	0.059
Schistosoma mansoni	glucose transport protein	0.0126	0.1546	0.4336
Onchocerca volvulus		0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Brugia malayi	Serotonin receptor	0.0031	0.021	0.021
Schistosoma mansoni	neuropeptide receptor	0.0031	0.021	0.059
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Trichomonas vaginalis	conserved hypothetical protein	0.0126	0.1546	1
Brugia malayi	larval opioid receptor	0.0031	0.021	0.021
Plasmodium vivax	sugar transporter, putative	0.0018	0.0032	0.0044
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0039	0.0324	0.0446
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Trypanosoma cruzi	hexose transporter	0.0039	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0324	0.0324
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0022	0.0085	0.0238
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0039	0.0324	0.0446
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0018	0.0032	0.0089
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Schistosoma mansoni	amine GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0031	0.021	0.021
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0031	0.021	0.021
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.021	0.059
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0031	0.021	0.059
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.04	0.04
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.0474	0.0653
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Plasmodium falciparum	protein kinase 7	0.0357	0.4762	0.6557
Leishmania major	C-8 sterol isomerase-like protein	0.0732	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.0474	0.0474
Schistosoma mansoni	hypothetical protein	0.0016	0.0009	0.0025
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0022	0.0085	0.0238
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0039	0.0324	0.0324
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.021	0.059
Schistosoma mansoni	sugar transporter	0.0018	0.0032	0.0089
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Schistosoma mansoni	hypothetical protein	0.0035	0.027	0.0757
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0022	0.0085	0.0238
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	GABA receptor subunit	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Giardia lamblia	Prolyl-tRNA synthetase	0.0038	0.0313	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0022	0.0085	0.0085
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.021	0.059
Entamoeba histolytica	protein kinase, putative	0.0039	0.0324	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Echinococcus multilocularis	glycine receptor subunit beta	0.0022	0.0085	0.0238
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0031	0.021	0.021
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0039	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0018	0.0032	0.0044
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0022	0.0085	0.0238
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0039	0.0324	0.068
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0083	0.0083
Echinococcus multilocularis	solute carrier family 22	0.0018	0.0032	0.0089
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.021	0.059
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0031	0.021	0.059
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0022	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0009
Onchocerca volvulus		0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Brugia malayi	lysyl-tRNA synthetase	0.0028	0.0177	0.0177
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Echinococcus granulosus	orexin receptor type 2	0.0031	0.021	0.059
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Brugia malayi	follicle stimulating hormone receptor	0.0031	0.021	0.021
Leishmania major	glucose transporter, lmgt3	0.0039	0.0331	0.0331
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0022	0.0085	0.0085
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0022	0.0085	0.0238
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0022	0.0085	0.0238
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0031	0.021	0.059
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0039	0.0324	0.068
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0204	0.2631	0.3623
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0094	0.0263
Schistosoma mansoni	sugar transporter	0.0018	0.0032	0.0089
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.021	0.059
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0028	0.0177	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Schistosoma mansoni	neuropeptide receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0039	0.0324	0.0324
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	sex peptide receptor	0.0031	0.021	0.059
Echinococcus granulosus	nAChR subunit	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Onchocerca volvulus		0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus multilocularis	allatostatin A receptor	0.0031	0.021	0.059
Leishmania major	protein kinase, putative	0.0039	0.0324	0.0324
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0038	0.0313	0.0313
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0022	0.0085	0.0238
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0022	0.0085	0.0238
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0038	0.0313	0.0877
Schistosoma mansoni	opsin-like receptor	0.0031	0.021	0.059
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0495	0.0495
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.021	0.059
Schistosoma mansoni	growth hormone secretagogue receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	TYRA-2 protein	0.0031	0.021	0.021
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.021	0.021
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Schistosoma mansoni	protein kinase	0.0039	0.0324	0.0908
Onchocerca volvulus		0.0022	0.0085	0.2966
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0331	0.1973
Echinococcus granulosus	g protein coupled receptor	0.0031	0.021	0.059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.021	0.021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Schistosoma mansoni	glucose transport protein	0.0126	0.1546	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0474	0.0474
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0031	0.021	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0044	0.04	0.0551
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.021	0.059
Schistosoma mansoni	hypothetical protein	0.0022	0.0094	0.0263
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.021	0.059
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0018	0.0032	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0022	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.0474	0.0653
Brugia malayi	putative neuropeptide receptor NPR1	0.0031	0.021	0.021
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0022	0.0085	0.0085
Brugia malayi	excitatory GABA receptor EXP-1A	0.0022	0.0085	0.0085
Onchocerca volvulus		0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0204	0.2631	0.5525
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Schistosoma mansoni	amine GPCR	0.0031	0.021	0.059
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0495	0.0495
Trichomonas vaginalis	CAMK family protein kinase	0.0039	0.0324	0.1927
Echinococcus multilocularis	solute carrier family 22	0.0018	0.0032	0.0089
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0009	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0031	0.021	0.059
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.021	0.059
Loa Loa (eye worm)	ACC-1 protein	0.0022	0.0085	0.0085
Loa Loa (eye worm)	sugar transporter	0.0126	0.1546	0.1546
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0038	0.0313	0.0877
Schistosoma mansoni	hypothetical protein	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0038	0.0313	0.1855
Echinococcus granulosus	g protein coupled receptor	0.0031	0.021	0.059
Brugia malayi	Melatonin receptor type 1A	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Echinococcus granulosus	serotonin receptor	0.0031	0.021	0.059
Echinococcus granulosus	nAChR subunit	0.0022	0.0085	0.0238
Brugia malayi	RE15519p	0.0031	0.021	0.021
Echinococcus granulosus	synaptic vesicle 2 protein	0.0018	0.0032	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.021	0.059
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Toxoplasma gondii	facilitative glucose transporter GT1	0.0126	0.1546	0.3246
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.021	0.059
Schistosoma mansoni	hypothetical protein	0.0126	0.1546	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Onchocerca volvulus		0.0031	0.021	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	melatonin receptor type 1A	0.0031	0.021	0.021
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0038	0.0313	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0085	0.0085
Toxoplasma gondii	sugar transporter ST1	0.0018	0.0032	0.0067
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0031	0.021	0.059
Echinococcus granulosus	neuropeptide FF receptor 2	0.0031	0.021	0.059
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Leishmania major	hypothetical protein, conserved	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Brugia malayi	neuropeptide F receptor	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Brugia malayi	Dopamine receptor protein 2	0.0031	0.021	0.021
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0732	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0022	0.0085	0.0238
Toxoplasma gondii	transporter, major facilitator family protein	0.0018	0.0032	0.0067
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.0085	0.0238
Echinococcus granulosus	General substrate transporter	0.0108	0.1298	0.3641
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.021	0.059
Echinococcus multilocularis	nAChR subunit	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus multilocularis	calcium dependent protein kinase	0.0036	0.029	0.0814
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0126	0.1546	0.4336
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0039	0.0324	0.0324
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Plasmodium vivax	hexose transporter	0.0126	0.1546	0.2129
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0214	0.0214
Trichomonas vaginalis	glucose transporter, putative	0.0039	0.0331	0.1973
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0094	0.0263
Giardia lamblia	Lysyl-tRNA synthetase	0.0028	0.0177	0.5182
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Brugia malayi	Cam kinase protein 1	0.0039	0.0324	0.0324
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.0331	0.0331
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0018	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0018	0.0032	0.0032
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0313	0.0313
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.0331	0.0331
Trypanosoma brucei	glucose transporter, putative	0.0039	0.0331	0.0331
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0031	0.021	0.021
Leishmania major	lysyl-tRNA synthetase, putative	0.0028	0.0177	0.0177
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0022	0.0085	0.0085
Echinococcus granulosus	sex peptide receptor	0.0031	0.021	0.059
Brugia malayi	GnHR receptor homolog	0.0031	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0039	0.0324	0.0446
Schistosoma mansoni	hypothetical protein	0.0031	0.021	0.059
Echinococcus multilocularis	dro:myosuppressin receptor	0.0031	0.021	0.059
Echinococcus multilocularis	solute carrier family 22	0.0018	0.0032	0.0089
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0044	0.04	0.0841
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.0474	0.0474
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.021	0.059
Trypanosoma cruzi	glucose transporter, putative	0.0018	0.0032	0.0032
Leishmania major	glucose transporter, lmgt2	0.0039	0.0331	0.0331
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0022	0.0085	0.0238
Schistosoma mansoni	nAChR subunit	0.0022	0.0085	0.0238
Brugia malayi	G-protein coupled receptor	0.0031	0.021	0.021
Schistosoma mansoni	sugar transporter	0.0018	0.0032	0.0089
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.021	0.059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.021	0.059
Loa Loa (eye worm)	hypothetical protein	0.0271	0.3565	0.3565
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.021	0.059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.021	0.059
Plasmodium falciparum	proline--tRNA ligase	0.0044	0.04	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.021	0.059
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0126	0.1546	0.4336
Onchocerca volvulus		0.0031	0.021	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	glycine receptor subunit beta	0.0022	0.0085	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0085	0.0085
Schistosoma mansoni	biogenic amine receptor	0.0031	0.021	0.059
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0044	0.04	0.04
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.0032
Schistosoma mansoni	lysyl-tRNA synthetase	0.0028	0.0177	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0039	0.0324	0.0908
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0009	0.0025
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.0331	0.1973
Schistosoma mansoni	hypothetical protein	0.0031	0.021	0.059
Brugia malayi	hypothetical protein	0.0031	0.021	0.021
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0031	0.021	0.059
Echinococcus granulosus	glycine receptor subunit beta	0.0022	0.0085	0.0238
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0536	0.7262	1
Onchocerca volvulus		0.0031	0.021	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0022	0.0085	0.0085
Brugia malayi	ORL1-like opioid receptor	0.0031	0.021	0.021
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0031	0.021	0.059
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0009	0.0009
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0031	0.021	0.059
Brugia malayi	Serotonin receptor	0.0031	0.021	0.021
Echinococcus granulosus	7TM GPCR rhodopsin	0.0031	0.021	0.059
Toxoplasma gondii	lysine-tRNA ligase	0.0028	0.0177	0.0372

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 6.22	SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2449336

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1809647