Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.2333 | 0.1853 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.1029 | 0.078 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0467 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0467 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.4069 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.1029 | 0.078 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.4069 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.2333 | 0.1853 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0088 | 0.1306 | 0.0305 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0467 | 1 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.113 | 0.011 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.4069 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.1029 | 0.078 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0467 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0208 | 0.4069 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.2333 | 0.212 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.4069 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0467 | 1 | 1 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.2333 | 0.2333 |
Echinococcus granulosus | dihydrofolate reductase | 0.0467 | 1 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.1889 | 0.1889 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0088 | 0.1306 | 0.0305 |
Brugia malayi | Dihydrofolate reductase | 0.0467 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0153 | 0.2793 | 0.2793 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.1029 | 0.1998 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.2333 | 0.212 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.2333 | 0.212 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.1889 | 0.1889 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2793 | 0.1964 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0467 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.4069 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0467 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0088 | 0.1306 | 0.1306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14.8 uM | Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetry | ChEMBL. | 20598554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.