Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0052 | 0.0052 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.077 | 1 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0023 | 0.0027 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0132 | 0.1623 | 0.1623 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.042 | 0.2589 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0132 | 0.1623 | 0.1964 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0132 | 0.1623 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0132 | 0.1623 | 0.1623 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0077 | 0.0094 |
Plasmodium vivax | hypothetical protein, conserved | 0.0132 | 0.1623 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0052 | 0.0323 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0458 | 0.0458 |
Echinococcus multilocularis | 0.0132 | 0.1623 | 0.1623 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Toxoplasma gondii | flagellar/basal body protein | 0.0132 | 0.1623 | 0.5 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0132 | 0.1623 | 0.1964 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0077 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.077 | 1 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0052 | 0.0052 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.051 | 0.051 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0132 | 0.1623 | 0.1964 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0077 | 0.0094 |
Onchocerca volvulus | 0.077 | 1 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0077 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.1623 | 0.1623 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0132 | 0.1623 | 0.1623 |
Onchocerca volvulus | 0.077 | 1 | 1 | |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0132 | 0.1623 | 1 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.077 | 1 | 1 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0132 | 0.1623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 0.8264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 0.1623 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0132 | 0.1623 | 0.5 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0132 | 0.1623 | 0.1623 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Schistosoma mansoni | peptidase | 0.0132 | 0.1623 | 0.1623 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0132 | 0.1623 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0052 | 0.0052 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0077 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0458 | 0.282 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.042 | 0.2589 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0132 | 0.1623 | 0.1964 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0132 | 0.1623 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0132 | 0.1623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0052 | 0.0063 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0132 | 0.1623 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0132 | 0.1623 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 1 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0132 | 0.1623 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | peptidase | 0.0132 | 0.1623 | 0.1623 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0132 | 0.1623 | 0.1623 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0132 | 0.1623 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0132 | 0.1623 | 0.1623 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0458 | 0.0554 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0132 | 0.1623 | 0.1623 |
Schistosoma mansoni | peptidase | 0.0132 | 0.1623 | 0.1623 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0077 | 0.0477 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0132 | 0.1623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Onchocerca volvulus | 0.077 | 1 | 1 | |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0132 | 0.1623 | 1 |
Onchocerca volvulus | 0.077 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0382 | 0.0463 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1623 | 0.1964 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0132 | 0.1623 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0132 | 0.1623 | 1 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0132 | 0.1623 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0132 | 0.1623 | 1 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0132 | 0.1623 | 0.1623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.