TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 499.55 | Formula: C27H31F2N3O4
H donors: 0 H acceptors: 3 LogP: 3.12 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1CCN(CC1)CC(=O)N1C(CC(=O)C(C1c1ccc(cc1)F)C)c1ccc(cc1)F
InChi: 1S/C27H31F2N3O4/c1-3-36-27(35)31-14-12-30(13-15-31)17-25(34)32-23(19-4-8-21(28)9-5-19)16-24(33)18(2)26(32)20-6-10-22(29)11-7-20/h4-11,18,23,26H,3,12-17H2,1-2H3
InChiKey: NZDZZCVKNLJPDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.052	0.0504
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus granulosus	ryanodine receptor 44f	0.006	0.1421	0.136
Echinococcus granulosus	sodium channel protein	0.006	0.1421	0.136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel protein	0.006	0.1421	0.136
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.052	0.0452
Brugia malayi	Transient-receptor-potential like protein	0.006	0.1421	0.176
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.052	0.0452
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Schistosoma mansoni	opsin-like receptor	0.0035	0.052	0.052
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.0224	0.7332	1
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.0224	0.7332	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.006	0.1421	0.136
Echinococcus granulosus	orexin receptor type 2	0.0035	0.052	0.0452
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.052	0.0452
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.006	0.1421	0.176
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Echinococcus multilocularis	short transient receptor potential channel 6	0.006	0.1421	0.136
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.052	0.0452
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Brugia malayi	neuropeptide F receptor	0.0035	0.052	0.0504
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Schistosoma mansoni	biogenic amine receptor	0.0035	0.052	0.052
Echinococcus multilocularis	allatostatin A receptor	0.0035	0.052	0.0452
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.006	0.1421	0.166
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	serotonin receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.052	0.0452
Brugia malayi	ORL1-like opioid receptor	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	serotonin receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Schistosoma mansoni	histamine h1 receptor	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	shaker cognate	0.006	0.1421	0.136
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.052	0.052
Toxoplasma gondii	transporter, cation channel family protein	0.006	0.1421	0.166
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.006	0.1421	0.166
Brugia malayi	voltage-dependent calcium channel	0.006	0.1421	0.176
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Dopamine receptor	0.0035	0.052	0.0504
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.052	0.0452
Echinococcus granulosus	voltage gated hydrogen channel 1	0.006	0.1421	0.136
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.006	0.1421	0.1421
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.006	0.1421	0.176
Echinococcus multilocularis	conserved hypothetical protein	0.006	0.1421	0.136
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.0224	0.7332	0.7332
Schistosoma mansoni	bromodomain containing protein	0.0065	0.1579	0.1579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Schistosoma mansoni	hypothetical protein	0.006	0.1421	0.1421
Schistosoma mansoni	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0566	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel protein	0.006	0.1421	0.136
Echinococcus granulosus	potassium voltage gated channel protein	0.006	0.1421	0.136
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.006	0.1421	0.166
Echinococcus granulosus	two pore calcium channel protein 2	0.006	0.1421	0.136
Echinococcus multilocularis	hyperpolarization activated cyclic	0.006	0.1421	0.136
Brugia malayi	Melatonin receptor type 1A	0.0035	0.052	0.0504
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.006	0.1421	0.1878
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	sex peptide receptor	0.0035	0.052	0.0452
Schistosoma mansoni	neuropeptide receptor	0.0035	0.052	0.052
Echinococcus granulosus	hypothetical protein	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Serotonin receptor	0.0035	0.052	0.0504
Brugia malayi	GnHR receptor homolog	0.0035	0.052	0.0504
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.006	0.1421	0.136
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0244	0.0175
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.006	0.1421	0.136
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.052	0.0452
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.052	0.0452
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.006	0.1421	0.176
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.006	0.1421	0.1878
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel protein	0.006	0.1421	0.136
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.052	0.0504
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	voltage gated potassium channel	0.006	0.1421	0.136
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.0224	0.7332	1
Echinococcus multilocularis	two pore calcium channel protein 1	0.006	0.1421	0.136
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.052	0.052
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.006	0.1421	0.176
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Schistosoma mansoni	myosin xvIII	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0244	0.0244
Schistosoma mansoni	transient receptor potential channel 4	0.006	0.1421	0.1421
Schistosoma mansoni	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.006	0.1421	0.176
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.006	0.1421	0.1878
Brugia malayi	RNA, U transporter 1	0.0079	0.2103	0.2711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Brugia malayi	ion channel NompC	0.006	0.1421	0.176
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.052	0.0504
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	ryanodine receptor 44f	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	hyperpolarization activated cyclic	0.006	0.1421	0.136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Brugia malayi	protein-S isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.006	0.1421	0.1878
Brugia malayi	putative neuropeptide receptor	0.0035	0.052	0.0504
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.0224	0.7332	1
Echinococcus multilocularis	voltage gated potassium channel	0.006	0.1421	0.136
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.006	0.1421	0.176
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus multilocularis	transient receptor potential gamma protein	0.006	0.1421	0.136
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.052	0.052
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.006	0.1421	0.136
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.006	0.1421	0.136
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.052	0.0452
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.052	0.052
Schistosoma mansoni	voltage-gated ion channel	0.006	0.1421	0.1421
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.006	0.1421	0.176
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	sodium leak channel non selective protein	0.006	0.1421	0.136
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.1446	0.1385
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.006	0.1421	0.136
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.052	0.0504
Toxoplasma gondii	transporter, cation channel family protein	0.006	0.1421	0.166
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.006	0.1421	0.136
Loa Loa (eye worm)	calcium channel	0.006	0.1421	0.1421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus multilocularis	voltage dependent calcium channel	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	voltage-gated calcium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.006	0.1421	0.136
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.052	0.052
Echinococcus granulosus	voltage dependent calcium channel	0.006	0.1421	0.136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	calcium activated potassium channel	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0657	0.0657
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.052	0.052
Schistosoma mansoni	amine GPCR	0.0035	0.052	0.052
Toxoplasma gondii	transporter, cation channel family protein	0.006	0.1421	0.166
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Brugia malayi	Bromodomain containing protein	0.0039	0.0654	0.0691
Echinococcus multilocularis	calcium activated potassium channel	0.006	0.1421	0.136
Echinococcus granulosus	voltage gated potassium channel	0.006	0.1421	0.136
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.052	0.0452
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.052	0.0452
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.052	0.0452
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	short transient receptor potential channel 6	0.006	0.1421	0.136
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.052	0.0452
Schistosoma mansoni	opsin-like receptor	0.0035	0.052	0.052
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.052	0.052
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.006	0.1421	0.136
Onchocerca volvulus		0.006	0.1421	1
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.052	0.052
Schistosoma mansoni	neuropeptide receptor	0.0035	0.052	0.052
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	voltage-gated potassium channel	0.006	0.1421	0.1421
Schistosoma mansoni	transient receptor potential channel	0.006	0.1421	0.1421
Schistosoma mansoni	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.052	0.0452
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.006	0.1421	0.1421
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.052	0.052
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.052	0.0452
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.052	0.0452
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.0224	0.7332	1
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.006	0.1421	0.166
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.052	0.0452
Echinococcus multilocularis	sodium leak channel non selective protein	0.006	0.1421	0.136
Schistosoma mansoni	opsin-like receptor	0.0035	0.052	0.052
Brugia malayi	cation channel family protein	0.006	0.1421	0.176
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.052	0.052
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.006	0.1421	0.1421
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.006	0.1421	0.136
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.052	0.0452
Echinococcus multilocularis	short transient receptor potential channel 6	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	1	1
Echinococcus granulosus	serotonin receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.052	0.052
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.006	0.1421	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.006	0.1421	0.136
Echinococcus multilocularis	two pore calcium channel protein 2	0.006	0.1421	0.136
Echinococcus granulosus	neuropeptide receptor	0.0035	0.052	0.0452
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Cyclic-nucleotide gated cation channel	0.006	0.1421	0.176
Brugia malayi	Bromodomain containing protein	0.0077	0.2013	0.2585
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.052	0.0452
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.052	0.052
Echinococcus granulosus	shaker cognate	0.006	0.1421	0.136
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0098	0.2771	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.006	0.1421	0.1421
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.052	0.052
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.006	0.1421	0.136
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Echinococcus granulosus	fmrfamide receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	neuropeptide F receptor	0.0035	0.052	0.0504
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.052	0.0452
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Schistosoma mansoni	importin beta-1	0.0028	0.0244	0.0244
Schistosoma mansoni	amine GPCR	0.0035	0.052	0.052
Loa Loa (eye worm)	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.052	0.0452
Echinococcus granulosus	g protein coupled receptor	0.0035	0.052	0.0452
Schistosoma mansoni	adenoreceptor	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1854	0.1854
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.006	0.1421	0.1421
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.006	0.1421	0.136
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.052	0.0504
Mycobacterium ulcerans	hypothetical protein	0.0098	0.2771	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.006	0.1421	0.136
Echinococcus granulosus	hyperpolarization activated cyclic	0.006	0.1421	0.136
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.052	0.0452
Brugia malayi	G protein-coupled receptor	0.0035	0.052	0.0504
Schistosoma mansoni	transient receptor potential channel	0.006	0.1421	0.1421
Echinococcus multilocularis		0.0224	0.7332	0.7313
Schistosoma mansoni	voltage-gated cation channel	0.006	0.1421	0.1421
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.052	0.052
Brugia malayi	olfactory channel protein osm-9	0.006	0.1421	0.176
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.052	0.0452
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0071	0.0071
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.052	0.052
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.006	0.1421	0.136
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.0224	0.7332	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.006	0.1421	0.1421
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.052	0.052
Echinococcus multilocularis	voltage gated potassium channel	0.006	0.1421	0.136
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.006	0.1421	0.176
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.006	0.1421	0.1421
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	AKH receptor	0.0035	0.052	0.0504
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	transfer RNA-Gly	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.006	0.1421	0.176
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.006	0.1421	0.136
Schistosoma mansoni	hypothetical protein	0.0297	1	1
Schistosoma mansoni	vesicular amine transporter	0.006	0.1421	0.1421
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.052	0.052
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.052	0.0452
Brugia malayi	Dopamine receptor protein 1	0.0035	0.052	0.0504
Echinococcus granulosus	hypothetical protein	0.0035	0.052	0.0452
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.052	0.052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.006	0.1421	0.176
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.006	0.1421	0.136
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.006	0.1421	0.136
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0566	0.0499
Schistosoma mansoni	neuropeptide receptor	0.0035	0.052	0.052
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	neuropeptide receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.006	0.1421	0.176
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.006	0.1421	0.1421
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.006	0.1421	0.136
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.006	0.1421	0.1421
Echinococcus multilocularis	potassium large conductance calcium activated	0.006	0.1421	0.136
Echinococcus granulosus	sex peptide receptor	0.0035	0.052	0.0452
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.006	0.1421	0.1421
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.052	0.052
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.052	0.052
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.052	0.052
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.006	0.1421	0.136
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.052	0.0452
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.052	0.0452
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.006	0.1421	0.176
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.006	0.1421	0.136
Echinococcus multilocularis	sodium channel protein	0.006	0.1421	0.136
Schistosoma mansoni	transient receptor potential channel	0.006	0.1421	0.1421
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.052	0.0452
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.052	0.052
Echinococcus granulosus	somatostatin receptor	0.0035	0.052	0.0452
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.0224	0.7332	0.7332
Brugia malayi	G-protein coupled receptor	0.0035	0.052	0.0504
Brugia malayi	Serotonin receptor	0.0035	0.052	0.0504
Echinococcus granulosus	transient receptor potential cation channel	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.052	0.0452
Echinococcus granulosus	potassium voltage gated channel protein	0.006	0.1421	0.136
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.052	0.0452
Echinococcus granulosus	short transient receptor potential channel 6	0.006	0.1421	0.136
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.052	0.0504
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.052	0.052
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.052	0.0452
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.006	0.1421	0.136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Schistosoma mansoni	calcium-activated potassium channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.006	0.1421	1
Brugia malayi	larval opioid receptor	0.0035	0.052	0.0504
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Echinococcus multilocularis	somatostatin receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	TRP transient receptor potential channel	0.006	0.1421	0.136
Brugia malayi	RE15519p	0.0035	0.052	0.0504
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.006	0.1421	0.136
Schistosoma mansoni	voltage-dependent calcium channel	0.006	0.1421	0.1421
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.006	0.1421	0.176
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus granulosus	g protein coupled receptor	0.0035	0.052	0.0452
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.006	0.1421	0.176
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.052	0.0504
Brugia malayi	sulfakinin receptor protein	0.0035	0.052	0.0504
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.0224	0.7332	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.052	0.0452
Echinococcus granulosus	potassium voltage gated channel protein	0.006	0.1421	0.136
Echinococcus granulosus	allatostatin A receptor	0.0035	0.052	0.0452
Schistosoma mansoni	biogenic amine receptor	0.0035	0.052	0.052
Leishmania major	hypothetical protein, unknown function	0.006	0.1421	0.1878
Brugia malayi	cation channel family protein	0.006	0.1421	0.176
Schistosoma mansoni	amine GPCR	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	biogenic amine receptor	0.0035	0.052	0.052
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.1446	0.1385
Echinococcus multilocularis	potassium voltage gated channel protein	0.006	0.1421	0.136
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.006	0.1421	0.1421
Schistosoma mansoni	amine GPCR	0.0035	0.052	0.052
Echinococcus granulosus	g protein coupled receptor	0.0035	0.052	0.0452
Echinococcus granulosus	potassium voltage gated channel protein	0.006	0.1421	0.136
Toxoplasma gondii	hypothetical protein	0.006	0.1421	0.166
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.052	0.0452
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.006	0.1421	0.1421
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0815	0.0815
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.052	0.052
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.052	0.0452
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.006	0.1421	0.136
Schistosoma mansoni	amine GPCR	0.0035	0.052	0.052
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.006	0.1421	0.176
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.052	0.0452
Schistosoma mansoni	neuropeptide receptor	0.0035	0.052	0.052
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.052	0.0504
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.006	0.1421	0.136
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.006	0.1421	0.136
Brugia malayi	hypothetical protein	0.0035	0.052	0.0504
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.052	0.0452
Loa Loa (eye worm)	ryanodine receptor	0.006	0.1421	0.1421
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.0224	0.7332	1
Schistosoma mansoni	two-pore calcium channel	0.006	0.1421	0.1421
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.052	0.0452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0744	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.052	0.052
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0035	0.052	0.052
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.052	0.0452
Echinococcus granulosus	potassium voltage gated channel protein	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.006	0.1421	0.136
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.0224	0.7332	0.7313
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus granulosus	transient receptor potential gamma protein	0.006	0.1421	0.136
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.006	0.1421	0.1421
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.052	0.0452
Toxoplasma gondii	hypothetical protein	0.006	0.1421	0.166
Echinococcus multilocularis	voltage dependent calcium channel	0.006	0.1421	0.136
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.006	0.1421	0.136
Loa Loa (eye worm)	voltage-dependent calcium channel	0.006	0.1421	0.1421
Schistosoma mansoni	60S ribosomal protein L21	0.006	0.1421	0.1421
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Echinococcus multilocularis	hyperpolarization activated cyclic	0.006	0.1421	0.136
Brugia malayi	Importin beta-1 subunit	0.0028	0.0244	0.012
Echinococcus granulosus	potassium large conductance calcium activated	0.006	0.1421	0.136
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.052	0.0452
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.0224	0.7332	1
Leishmania major	hypothetical protein, conserved	0.006	0.1421	0.1878
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0244	0.0175
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Loa Loa (eye worm)	ion channel NompC	0.006	0.1421	0.1421
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.052	0.0452
Echinococcus multilocularis	snurportin 1	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.006	0.1421	0.1878
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.052	0.0452
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.052	0.0452
Echinococcus multilocularis	transient receptor potential cation channel	0.006	0.1421	0.136
Schistosoma mansoni	ryanodine receptor related	0.006	0.1421	0.1421
Brugia malayi	Dopamine receptor protein 2	0.0035	0.052	0.0504
Loa Loa (eye worm)	hypothetical protein	0.006	0.1421	0.1421
Schistosoma mansoni	voltage-gated potassium channel	0.006	0.1421	0.1421
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.052	0.0452
Brugia malayi	hypothetical protein	0.006	0.1421	0.176
Brugia malayi	G-protein coupled receptor	0.0035	0.052	0.0504
Echinococcus granulosus	two pore calcium channel protein 1	0.006	0.1421	0.136
Echinococcus granulosus	voltage dependent calcium channel	0.006	0.1421	0.136
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.006	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.052	0.052

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 25 ug ml-1	Antifungal activity against Candida albicans ATCC 3130 after 72 to 96 hr by two-fold serial dilution method	ChEMBL.	No reference
MIC (functional)	= 25 ug ml-1	Antifungal activity against Cryptococcus neoformans ATCC 3315 after 72 to 96 hr by two-fold serial dilution method	ChEMBL.	No reference
MIC (functional)	= 100 ug ml-1	Antibacterial activity against Escherichia coli ATCC 25840 after 24 hr by two-fold serial dilution method	ChEMBL.	No reference
MIC (functional)	> 256 ug ml-1	Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 21 days by BACTEC based radiometric respiratory technique	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2236090

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1815061