Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Polyketide synthase Pks13 | 0.076 | 0.7427 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0485 | 0.4023 | 0.3986 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0536 | 0.4652 | 0.6263 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium ulcerans | thioesterase | 0.0432 | 0.3375 | 0.4544 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0328 | 0.2079 | 0.2799 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0337 | 0.219 | 0.272 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.076 | 0.7427 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0163 | 0.0043 | 0.0058 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0503 | 0.4253 | 0.5702 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.076 | 0.7427 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0409 | 0.3084 | 0.4152 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0503 | 0.4253 | 0.4253 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0432 | 0.3375 | 0.4512 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0328 | 0.2079 | 0.2758 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0402 | 0.2999 | 0.4038 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0503 | 0.4253 | 0.5702 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0163 | 0.0043 | 0.0058 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0503 | 0.4253 | 0.5726 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0369 | 0.2595 | 0.3919 |
Brugia malayi | AMP-binding enzyme family protein | 0.0485 | 0.4023 | 0.4023 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0163 | 0.0041 | 0.0056 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0536 | 0.4652 | 0.6241 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0536 | 0.4652 | 0.6263 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0485 | 0.4023 | 0.5417 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0536 | 0.4652 | 0.6263 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0536 | 0.4652 | 0.6241 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.076 | 0.7427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0856 | 0.8617 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0503 | 0.4248 | 0.572 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0536 | 0.4652 | 0.6241 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0536 | 0.4652 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0373 | 0.2637 | 0.3551 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0536 | 0.4652 | 0.6263 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.021 | 0.0622 | 0.0838 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0432 | 0.3375 | 0.4544 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1431 | 0.0593 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0935 | 0.9596 | 1 |
Onchocerca volvulus | 0.0903 | 0.9198 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0295 | 0.1675 | 0.2256 |
Loa Loa (eye worm) | fatty acid synthase | 0.0512 | 0.4359 | 0.4427 |
Mycobacterium ulcerans | polyketide synthase | 0.0536 | 0.4652 | 0.6263 |
Mycobacterium ulcerans | thioesterase TesA | 0.0432 | 0.3375 | 0.4544 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0328 | 0.2079 | 0.2799 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0503 | 0.4253 | 0.5726 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0503 | 0.4248 | 0.572 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0402 | 0.2999 | 0.4003 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0402 | 0.2999 | 0.4038 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0536 | 0.4652 | 0.6263 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.