Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.9839 | 0.9839 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0031 | 0.3861 | 0.3861 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0031 | 0.3861 | 0.3861 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | beta tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | alpha-tubulin | 0.0031 | 0.3861 | 0.3861 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0031 | 0.3861 | 0.3861 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | Tubulin beta-1 chain | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | alpha tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0031 | 0.3861 | 0.3861 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | alpha-tubulin | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | alpha-tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin beta chain | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | tubulin alpha-2 chain | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | Tubulin gamma chain | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | beta-tubulin, identical | 0.0031 | 0.3861 | 0.3861 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0031 | 0.3861 | 0.3861 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0031 | 0.3861 | 0.3861 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 1 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0031 | 0.3861 | 0.3861 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Trypanosoma brucei | tubulin gamma chain | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | epsilon tubulin | 0.0031 | 0.3861 | 0.3861 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | Tubulin alpha-2 chain | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | alpha tubulin | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | Tubulin alpha chain | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | epsilon tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | BEN-1 protein | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | alpha tubulin | 0.0031 | 0.3861 | 0.3861 |
Brugia malayi | Tubulin alpha-2 chain | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma brucei | alpha tubulin | 0.0031 | 0.3861 | 0.3861 |
Loa Loa (eye worm) | BEN-1 protein | 0.0031 | 0.3861 | 0.3861 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3861 | 0.3861 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.3 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.