Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | 484 aa | 469 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Fxna peptidase homolog | 0.0463 | 0.1547 | 0.1547 |
Leishmania major | glutaminyl cyclase, putative | 0.0463 | 0.1547 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0463 | 0.1547 | 0.1547 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0463 | 0.1547 | 0.1547 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0463 | 0.1547 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.1547 | 0.1547 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0463 | 0.1547 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0463 | 0.1547 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0463 | 0.1547 | 0.1547 |
Brugia malayi | FXNA | 0.0463 | 0.1547 | 0.1547 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0463 | 0.1547 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0463 | 0.1547 | 0.1547 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0463 | 0.1547 | 0.1547 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.1547 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0463 | 0.1547 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0463 | 0.1547 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0463 | 0.1547 | 0.1547 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0463 | 0.1547 | 0.1547 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0463 | 0.1547 | 0.1547 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0463 | 0.1547 | 0.1547 |
Loa Loa (eye worm) | hypothetical protein | 0.2907 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2907 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0463 | 0.1547 | 0.1547 |
Mycobacterium tuberculosis | Conserved protein | 0.0463 | 0.1547 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0463 | 0.1547 | 0.1547 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.1547 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0463 | 0.1547 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.1547 | 0.5 |
Brugia malayi | nicalin | 0.0463 | 0.1547 | 0.1547 |
Schistosoma mansoni | nicalin (M28 family) | 0.0463 | 0.1547 | 0.1547 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.1547 | 0.1547 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2907 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.1547 | 0.1547 |
Mycobacterium ulcerans | hypothetical protein | 0.0463 | 0.1547 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0463 | 0.1547 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0463 | 0.1547 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0463 | 0.1547 | 0.1547 |
Onchocerca volvulus | 0.0463 | 0.1547 | 0.1547 | |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.1547 | 0.1547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 208 nM | Displacement of [3H]granisetron from human 5HT3A expressed in HEK293 cells after 1 hr by scintillation counting | ChEMBL. | 22189135 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.